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Method for preparation of fluorescent aqueous two-phase system based on carbon quantum dots

A technology of carbon quantum dots and two-phase water, which is applied in the fields of fluorescence/phosphorescence, chemical instruments and methods, and luminescent materials, and can solve the problems of complex synthesis methods and expensive synthesis instruments

Inactive Publication Date: 2017-04-05
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] The technical problem to be solved in the present invention is aimed at the shortcomings of traditional quantum dots. For example, the synthetic materials are all noble metals or heavy metals, the synthetic methods are complicated, and the synthetic instruments are more expensive. Phosphorus prepares carbon quantum dots by wet chemical method, the preparation process is simple, and at the same time, a higher quantum yield and better photostability are obtained

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  • Method for preparation of fluorescent aqueous two-phase system based on carbon quantum dots
  • Method for preparation of fluorescent aqueous two-phase system based on carbon quantum dots
  • Method for preparation of fluorescent aqueous two-phase system based on carbon quantum dots

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Embodiment 1

[0028] a, phosphorus pentoxide wet chemical method to prepare carbon quantum dots: 0.08g 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF 4 ) was added to 4mL distilled water, stirred evenly, the mixed solution was put into a round-bottomed flask containing 5g phosphorus pentoxide and heated for 5min, the solution changed from colorless to yellow, and cooled to room temperature to obtain carbon quantum dots;

[0029] b. The application of the fluorescent aqueous two-phase of the present invention in drug detection, the above-mentioned 120 μL carbon quantum dots are dissolved in 5 mL of distilled water and then 1.5 g of sodium dihydrogen phosphate is added to establish a fluorescent two-water two-phase and the fluorescent two-water two-phase is used for The method of drug detection is carried out through the following steps: at room temperature, in several 10mL colorimetric tubes, sequentially add 120μL of prepared carbon quantum dots, 5mL of distilled water and 1.5g of s...

Embodiment 2

[0031] a. Prepare carbon quantum dots by phosphorus pentoxide wet chemical method: add 0.40g 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([Emim]OTF) into 6mL distilled water, stir well, mix Put the solution into a round-bottomed flask containing 4.5 g of phosphorus pentoxide and heat it for 6 minutes, the solution turns from colorless to yellow, and cools to room temperature to obtain carbon quantum dots;

[0032] b. The application of the fluorescent aqueous two-phase of the present invention in drug detection, the above-mentioned 180 μL carbon quantum dots are dissolved in 4 mL of distilled water and then 3.6 g of sodium dihydrogen phosphate is added to establish a fluorescent two-water phase and the fluorescent two-water phase is used for The method of drug detection is carried out through the following steps: at room temperature, in several 10mL colorimetric tubes, sequentially add 180μL of prepared carbon quantum dots, 4mL of distilled water and 3.6g of sodium di...

Embodiment 3

[0034]a. Prepare carbon quantum dots by phosphorus pentoxide wet chemical method: add 0.30g 1-hexyl-3-methylimidazolium chloride salt ([Hmim]Cl) to 1mL distilled water, stir evenly, put the mixed solution into a 5.5 Heating in a round-bottomed flask of g phosphorus pentoxide for 5min, the solution turns from colorless to yellow, and is cooled to room temperature to obtain carbon quantum dots;

[0035] b. The application of the fluorescent aqueous two-phase of the present invention in drug detection, the above-mentioned 140 μL carbon quantum dots are dissolved in 8 mL of distilled water and then 3.8 g of sodium dihydrogen phosphate is added to establish a fluorescent two-water two-phase and the fluorescent two-water two-phase is used for The method of drug detection is carried out through the following steps: at room temperature, in several 10mL colorimetric tubes, sequentially add 140μL of prepared carbon quantum dots, 8mL of distilled water and 3.8g of sodium dihydrogen phosph...

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Abstract

The invention relates to a method for preparation of a fluorescent aqueous two-phase system based on carbon quantum dots and a method for simultaneously realizing high efficient drug enrichment and high sensitivity detection through the fluorescent aqueous two-phase system. The method comprises uniformly mixing an ionic liquid and distilled water, adding the mixture into a round-bottom flask with phosphorus pentoxide, carrying out a heating reaction process to obtain hydrophilic carbon dots, then adding a certain amount of sodium dihydrogen phosphate and water into the hydrophilic carbon dots to obtain the fluorescent aqueous two-phase system, and finally determining a trace amount of drugs in a complex matrix through fluorescence quenching.

Description

technical field [0001] The invention relates to the preparation of a carbon quantum dot with an ionic liquid as a precursor, and the construction of a fluorescent two-phase aqueous phase, which is applied to realize the high-efficiency enrichment and high-sensitivity detection of drugs at the same time. Background technique [0002] Liquid-liquid extraction (LLE) is a commonly used separation technique in the chemical industry and analytical chemistry, and is widely used in the separation, preparation and sample pretreatment of biology, medicine, food and other fields. The traditional liquid-liquid extraction system is mainly a two-phase system formed by organic solvent and aqueous solution. However, due to the shortcomings of organic solvents such as volatility, flammability and toxicity, as the international community pays more and more attention to environmental issues, the use of organic solvents has been restricted to varying degrees. In recent years, aqueous two-phase...

Claims

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Application Information

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IPC IPC(8): C09K11/65G01N21/64
Inventor 何华王娜潘仁锋肖得力彭军李思桥
Owner CHINA PHARM UNIV