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Biosensor for sensing analytes in sweat and method of making the same

A biosensor, analyte technology, applied in biochemical equipment and methods, sensors, analytical materials, etc., can solve the skin discomfort, irritation and other problems of sensitive patients

Active Publication Date: 2019-08-27
STMICROELECTRONICS SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, devices according to this technology may cause skin discomfort or irritation in sensitive patients due to the presence of an electrical current flowing through the skin itself

Method used

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  • Biosensor for sensing analytes in sweat and method of making the same
  • Biosensor for sensing analytes in sweat and method of making the same
  • Biosensor for sensing analytes in sweat and method of making the same

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Embodiment Construction

[0014] figure 1 The biosensor 1 according to one aspect of the present disclosure is shown in a three-axis reference frame X, Y, Z. The biosensor 1 includes: a first structural layer 2 of photosensitive hydrogel; a second structural layer 4 of photosensitive hydrogel, which extends on the first structural layer 2, and a sensing area 6, which includes biological Recognition elements, particularly the matrix of photosensitive hydrogels of enzymes such as GOx (glucose oxidase) and LOx (lactate oxidase). The second structure layer 4 has a through opening 8 in the sensing region 6 so that the sensing region 6 is at least partially exposed to the external environment through the through opening 8.

[0015] The working electrical terminal 10 is arranged to be in electrical contact with the sensing area 6, while the counter electrode electrical terminal is arranged on the first layer 2 (or part of the first layer 2) next to the sensing area 6, and is not connected to the sensing area 6. ...

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Abstract

A biosensor (1; 1'), comprising: a first structural layer (2; 2') of a photodefinable hydrogel; a second structural layer (4; 4') of a photodefinable hydrogel ; extending between said first structural layer (2; 2') and said second structural layer (4; 4') and consisting of a photodefinable hydrogel comprising a biorecognition element and a reduction-oxidation mediator A fabricated bioactive area (6; 6'); a working electrode (10; 10') extending to be in direct contact with said bioactive area (6; 6'); extending to contact with a first structural layer (2; 2 ') in direct contact with the counter electrode (12; 12'). The second structural layer (4; 4') has a through-opening (8; 8') in the bioactive area (6; 6'), so that the bioactive area (6; 6') and the biosensor The outside environment is directly fluidly connected.

Description

Technical field [0001] The present invention relates to a biosensor for sensing analytes in a fluid and a method for manufacturing the biosensor. In particular, the biosensor can be used to detect glucose and lactate in sweat . Background technique [0002] In medical diagnosis, wearable biosensors are very important to provide information related to the patient's current health status. [0003] A biosensor is a device used to sense analytes. The biosensor includes a biometric identification element (a sensitive biological element) and a sensing element, which converts the signal obtained by the interaction of the analyte with the biological element into a further signal that can be easily measured and quantified. [0004] In particular, unlike analysis based on blood samples, the analysis of sweat does not require an invasive process for collecting the sample to be analyzed. So far, the analysis of sweat has received special attention in the analysis of glucose and lactate. [0005...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/416
CPCG01N27/416A61B5/14517A61B5/14532A61B5/14546A61B5/1486A61B2562/125C12Q1/004G01N33/5436
Inventor H·尤埃莱V·迪帕尔玛
Owner STMICROELECTRONICS SRL