hepatitis B surface antigen resistant antibody and application thereof

Abstract

The invention relates to a hepatitis B surface antigen (HBsAg) resistant antibody (in particular to a humanized antibody), nucleic acid molecules for coding the antibody, a method for preparing the antibody and a pharmaceutical composition containing the antibody. In addition, the invention relates to application of the antibody and the pharmaceutical composition. The antibody and the pharmaceutical composition can be used for preventing and / or treating HBV infection and diseases (such as hepatitis B) related to the HBV infection, used for neutralizing the HBV virulence in the body of a subject (such as a person), or used for reducing the HBV DNA and / or HBsAg serum level in the body of the subject.

Description

technical field

[0001] The invention relates to the field of molecular virology and immunology, especially the field of treating hepatitis B virus (Hepatitis Bvirus, HBV) infection. Specifically, the present invention relates to antibodies (especially humanized antibodies) against hepatitis B surface antigen (HBsAg), nucleic acid molecules encoding them, methods for preparing them, and pharmaceutical compositions containing them. The pharmaceutical composition can be used to prevent and / or treat HBV infection or diseases related to HBV infection (such as hepatitis B), to neutralize the virulence of HBV in a subject (such as a human), or to treat Reduce the serum levels of HBV DNA and / or HBsAg in patients. Therefore, the present invention further relates to the use of said antibodies (especially humanized antibodies) and variants thereof in the preparation of pharmaceutical compositions for preventing and / or treating HBV infection or related to HBV infection diseases (such as...

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