Solid drug composition containing sarpogrelate hydrochloride

A technology of sarcogrelate hydrochloride and composition, which is applied in the field of sarcogrelate hydrochloride oral solid composition, and can solve the problems of poor selectivity and the like

Active Publication Date: 2017-04-26
TIANJIN CHASE SUN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent of this drug expired at the end of April 2006, but so far no generic drug of this product has passed the declaration in domestic enterprises
The drugs used in the past are purely inhibiting platelet aggregation, and the selectivity is not strong or simply dilating blood vessels

Method used

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  • Solid drug composition containing sarpogrelate hydrochloride
  • Solid drug composition containing sarpogrelate hydrochloride
  • Solid drug composition containing sarpogrelate hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 50

[0104] The preparation of embodiment 50mg and 100mg specification sagrelor hydrochloride film-coated tablet

[0105] prescription:

[0106]

[0107] Above-mentioned prescription is prepared into film-coated tablet through following steps:

[0108] a. Weigh the prescribed amount of sargrelate hydrochloride and citric acid and crush them through a 100-mesh sieve, lactose and starch through a 100-mesh sieve, hypromellose and hypromellose through a 80-mesh sieve, and magnesium stearate through a 60-mesh sieve sieve, spare;

[0109] b. The hypromellose that takes prescription quantity is configured into 2.5% solution with purified water as binder, for subsequent use;

[0110] c. After taking the prescribed amount of citric acid, hydroxypropyl cellulose and appropriate amount of lactose monohydrate and doubling and mixing, mix them with the prescribed amount of sargrel hydrochloride, starch, and the remaining lactose monohydrate, and set aside;

[0111] e. Add binder to make s...

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Abstract

The invention relates to a solid drug composition containing sarpogrelate hydrochloride, a preparation process and an application. Through selecting components and dosage of every auxiliary material in the preparation, a sarpogrelate hydrochloride coating tablet is obtained; the tablet is proper in disintegration; the hardness, and friability, and other indexes can reach the requirement of the coating process; the solid drug composition is featured by simple production process, convenience in production and stable quality.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an oral solid composition of sargrel hydrochloride and its preparation process and application. Background technique [0002] Sarpogrelate hydrochloride is a 5-hydroxytryptamine (5-HT2) receptor blocker that can specifically bind to 5-HT2 receptors. 5-hydroxytryptamine (5-HT) was first proposed as a vasoactive substance in 1955. 5-HT exists widely in animals, especially in the cardiovascular system. Except for a small part that is re-uptaked and stored in platelets, almost all 5-HT is inactivated by endothelial cells in the liver and lungs. Sagrelate hydrochloride can specifically bind to 5-HT2 receptors, showing a special antagonistic effect on receptors on platelets and vascular smooth muscle. Therefore, it exhibits anti-platelet effect and inhibits vasoconstriction, and exerts a series of biological effects. Sagrelate hydrochloride is an antithrombotic drug, m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/225A61K47/38A61P7/02A61P9/10
CPCA61K9/2059A61K9/2866A61K31/225
Inventor 魏征韩冬阚晓臣王桂霞郭新荣李宝齐郭嘉林孔凯董凯
Owner TIANJIN CHASE SUN PHARM CO LTD
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