Butylphthalide and nitrendipine soft capsule for relieving acute ischemic stroke

A technology for ischemic stroke and butylphthalide nitrendipine, which is applied in the field of butylphthalide nitrendipine soft capsules, can solve the problems of limited treatment methods, high price, and heavy drug burden for patients, and achieve cost reduction and low price , Alleviate the effect of acute ischemic stroke

Inactive Publication Date: 2017-04-26
SHANDONG PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment methods for acute ischemic stroke are limited. Butylphthalide is a commonly used drug, but the price is relatively expensive, and the burden of medication is large for patients

Method used

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  • Butylphthalide and nitrendipine soft capsule for relieving acute ischemic stroke
  • Butylphthalide and nitrendipine soft capsule for relieving acute ischemic stroke
  • Butylphthalide and nitrendipine soft capsule for relieving acute ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Capsule contents (5000 capsules):

[0024]

[0025] Capsule shell:

[0026]

[0027]

[0028] Preparation:

[0029] (1) Weigh glycerin and water in the formula amount, add to the tank and heat up to 75°C, stir evenly, slowly add gelatin and tragacanth gum, stir for 2 hours, remove air bubbles in a vacuum, cool down to 60°C and keep warm to obtain a capsule shell solution, spare;

[0030] (2) Take by weighing the butylphthalide and medicinal soybean oil of formula quantity, stir evenly, obtain material A, set aside;

[0031] (3) Take by weighing the nitrendipine and medium-chain triglycerides of the formula amount, stir evenly, obtain material B, and set aside;

[0032] (4) Material A and material B are mixed and stirred evenly to obtain the mixed material, and then the mixed material is mixed with the capsule shell solution by a soft capsule machine to make a soft capsule; The box and the spray body are heated, and the water pump circulation and cooling are...

Embodiment 2

[0037] Capsule contents (5000 capsules):

[0038]

[0039] Capsule shell:

[0040]

[0041] Preparation:

[0042] Take by weighing the sorbitol and water of recipe amount in the step (1), all the other are with embodiment 1.

[0043] The prepared samples (including 10 parallel samples numbered 1 to 10) were tested for content and disintegration time limit, and the test results are shown in Table 2. As can be seen from Table 2, the content uniformity of embodiment 2 is good.

[0044] Table 2. Content and disintegration time limit detection of embodiment 2

[0045]

Embodiment 3

[0047] Capsule contents (5000 capsules):

[0048]

[0049] Capsule shell:

[0050]

[0051] Preparation:

[0052] In the step (1), take by weighing the mannitol and water of formula quantity, all the other are with embodiment 1.

[0053] The content and disintegration time limit of the prepared samples (including 10 parallel samples numbered 1 to 10) were tested, and the test results are shown in Table 3. As can be seen from Table 3, the content uniformity of embodiment 3 is good.

[0054] Table 3. Content and disintegration time limit detection of embodiment 3

[0055]

[0056]

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PUM

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Abstract

The invention discloses a butylphthalide and nitrendipine soft capsule for relieving acute ischemic stroke. The butylphthalide and nitrendipine soft capsule comprises a capsule shell and capsule content, wherein the capsule content contains effective ingredients, medicinal soybean oil and medium-chain triglycerides in a mass ratio being 1:1:1-2, and the effective ingredients comprise butylphthalide and nitrendipine in a mass ratio being 1:3. The effective ingredients of the capsule content comprise butylphthalide and nitrendipine, and the cost is reduced greatly by addition of nitrendipine. Nitrendipine is insoluble in water and is easily degraded when exposed to light, butylphthalide and nitrendipine are dissolved in the medicinal soybean oil and the medium-chain triglycerides respectively in a preparation process, enabled to be dispersed sufficiently, combined and uniformly mixed, and the soft capsule with good uniformity is obtained. Acute ischemic stroke can be relieved effectively under the synergistic effect of butylphthalide and nitrendipine.

Description

technical field [0001] The invention relates to a soft capsule, in particular to a butylphthalide nitrendipine soft capsule for relieving acute ischemic stroke. Belongs to the technical field. Background technique [0002] Stroke, also known as stroke, is an acute cerebrovascular disease. It is a group of diseases that cause brain tissue damage due to sudden rupture of blood vessels in the brain or blockage of blood vessels that prevents blood from flowing into the brain, including ischemic and hemorrhagic strokes. The incidence of ischemic stroke is higher than that of hemorrhagic stroke, accounting for 60-70% of the total stroke. [0003] Acute ischemic stroke, also known as cerebral infarction, is the infarction of brain tissue caused by the occlusion of cerebral arteries, accompanied by the damage of neurons, astrocytes and oligodendrocytes, and is the leading cause of death in modern society. and disabling most important central nervous system vascular events. The tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/4422A61K9/48A61K47/44A61K47/14A61K47/36A61P9/10
CPCA61K9/4816A61K9/4858A61K31/365A61K31/4422A61K2300/00
Inventor 边红军周轶于镔
Owner SHANDONG PROVINCIAL HOSPITAL
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