Western medicine compound for treatment of spinal cord injury and use thereof

Abstract

The invention discloses a Western medicine compound for treatment of spinal cord injury and a use thereof. The Western medicine compound is composed of gabexate mesylate and nitrofurantoin, wherein the mass ratio of gabexate mesilate to nitrofurantoin is (0.09-0.13) to 1. When the Western medicine compound is applied to the treatment of spinal cord injury, the adult injection dosage of the Western medicine compound is 1.9-2.1 mg / kg, and the drug administration is performed 6-12 h later after spinal cord injury. Through test treatment of a spinal cord injury modeling animal, the Western medicine compound is found out to reduce cell apoptosis, promote nerve cell survival, inhibit formation of glial scar and significantly improve BBB scores of the animal after treatment, and the Western medicine compound is indicated to have a significant effect on promoting motion function recovery after spinal cord injury. Compared with a commonly used drug methylprednisolone for treating spinal cord injury in clinic at current, the Western medicine compound has the advantages of wider drug administration window, more lasting treatment effect and better long-term effect.

Description

technical field [0001] The invention relates to the technical field of western medicine, in particular to a western medicine compound for treating spinal cord injury and its application. Background technique [0002] Spinal cord injury is a serious complication of spinal fracture. Due to the displacement of the vertebral body or the protruding of bone fragments in the spinal canal, the spinal cord or cauda equina is damaged to varying degrees. It will be accompanied by fractures of the cervical, thoracic, thoracolumbar, lumbar, and sacral vertebrae, resulting in limb movement disorders, sensory disorders, and defecation disorders. It is more common in young adults, mostly males, and the most common injury site is the middle and lower cervical spinal cord, followed by the thoracolumbar junction. [0003] Spinal cord injury is composed of primary injury and secondary injury. The primary injury is tissue damage caused by mechanical external forces such as impact, cutting, blee...

AI Technical Summary

Problems solved by technology

[0005] Although a lot of research has been done on the pathophysiological mechanism of spinal cord injury in recent years, and the drugs represented by methylprednisolone (MP) have also achieved certain curative effects in clinical application, but the adverse reactions of the drugs and their Dosing limitations keep people searching for effective treatments

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