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Application of polypeptide in medicines for preventing or treating myocardial ischemia-reperfusion injury related diseases

A technology for reperfusion injury and myocardial ischemia, applied in the field of biomedicine, can solve limited problems, achieve extensive clinical application value, reduce myocardial ischemia-reperfusion injury, and reduce the size of myocardial infarction

Active Publication Date: 2017-04-26
GUANGDONG MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although the drugs currently used to prevent and treat MIRI have certain curative effects, they are very limited.

Method used

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  • Application of polypeptide in medicines for preventing or treating myocardial ischemia-reperfusion injury related diseases
  • Application of polypeptide in medicines for preventing or treating myocardial ischemia-reperfusion injury related diseases
  • Application of polypeptide in medicines for preventing or treating myocardial ischemia-reperfusion injury related diseases

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Embodiment Construction

[0009] In order to have a clearer understanding of the technical features, purposes and effects of the present invention, the specific implementation manners of the present invention will now be described with reference to the accompanying drawings. The following specific examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0010] The present inventors previously isolated a polypeptide-AdKI4 from Ancylostoma duodenale. Through a series of exploratory studies, the inventor firstly determined that AdKI4 can significantly reduce the size of myocardial infarction after myocardial ischemia-reperfusion by using the SD rat myocardial ischemia-reperfusion injury model in a dose-dependent manner, indicating that AdKI4 has a significant effect on ischemia-reperfusion. Myocardial injury has a good protective effect, therefore, AdKI4 can be used as a drug to prevent or treat diseases related to myocardial ischemia-r...

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Abstract

The invention discloses an application of an polypeptide in medicines for preventing or treating myocardial ischemia-reperfusion injury related diseases, and belongs to the field of biomedicines. The amino acid sequence of the polypeptide is SEQ ID NO.1 or SEQ ID NO.2. The polypeptide can substantially reduce the myocardial infarction area in myocardial ischemia-reperfusion injury, can be used as a medicine for preventing or treating the myocardial ischemia-reperfusion injury related diseases, and has clinic application values.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular the application of a polypeptide in preventing or treating diseases related to myocardial ischemia-reperfusion injury. Background technique [0002] Heart disease caused by myocardial ischemia, that is, ischemic heart disease, also known as coronary heart disease, is common and serious in clinical practice. Among them, myocardial infarction (MI) is the most harmful and fatal kind of myocardial ischemic heart disease. , with a high fatality rate. Restoring ischemic myocardial blood flow (reperfusion) is the most effective measure to treat myocardial ischemia, but reperfusion itself can lead to complex pathophysiological responses, aggravate myocardial injury, and cause myocardial ischemia-reperfusion injury (myocardialischemia reperfusion injury, MIRI). ). Currently, antioxidant therapy, adenosine receptor agonists, calcium antagonists, Na + / H + 、Na + / Ca 2+ Ion exchange inhibitors,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P9/10
CPCA61K38/1709
Inventor 彭礼飞罗辉邵正司徒永立邓莉何庆丰
Owner GUANGDONG MEDICAL UNIV
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