Chiral MOF (Metal-Organic Framework) magnetic graphene functional material, and preparation method and application thereof

A technology of magnetic graphene and functional materials, applied in chemical instruments and methods, preparation of organic compounds, and other chemical processes, can solve problems such as inability to achieve specific adsorption, and achieve superior drug enantiomer recognition performance and enrichment The separation process is simple and fast, and the effect of increasing the specific surface area

Inactive Publication Date: 2017-04-26
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since graphene itself cannot achieve specific adsorption, it must be further surface modified and functionalized, and functional groups can be grafted according to specific requirements to form functionalized magnetic graphene composites.

Method used

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  • Chiral MOF (Metal-Organic Framework) magnetic graphene functional material, and preparation method and application thereof
  • Chiral MOF (Metal-Organic Framework) magnetic graphene functional material, and preparation method and application thereof
  • Chiral MOF (Metal-Organic Framework) magnetic graphene functional material, and preparation method and application thereof

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Embodiment Construction

[0040] The present invention will be described in more detail below through specific examples. The experimental raw materials used are all commercially available products.

[0041] One, the preparation method of chiral MOF-magnetic graphene functional material of the present invention comprises the following specific steps:

[0042] The first step, the synthesis of graphene oxide (GO):

[0043] Weigh 1g of graphite powder in a 500mL three-necked flask, add 35mL of concentrated sulfuric acid in an ice bath, stir for 30min, and weigh 4gKMnO 4 Add slowly, then move to a constant temperature water bath at 35°C, stir for 12 hours, add 138mL of high-purity water to dilute while stirring, measure 12.5mL of hydrogen peroxide, add in, stir for 1 hour, centrifuge, wash with 5% dilute hydrochloric acid three times, and wash with deionized water until neutral , and dried in a vacuum oven at 60°C for 24 hours to obtain graphene oxide with good dispersibility.

[0044] In the second step...

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Abstract

The invention discloses a chiral MOF (Metal-Organic Framework) magnetic graphene functional material, which is synthesized by a normal-pressure in-situ synthesis method that magnetic graphene and a chiral MOF are subjected to cook in one pot. The chiral MOF magnetic graphene functional material synthesized by the method has the advantages of good dispersibility, stable structural properties, simple and quick synthesis method and the like. Compared with a traditional separation method, a magnetic solid phase extraction technology has the advantages of simpleness in operation, short analysis time, little required organic solvent and reuse. The chiral recognition capability of the composite material for a binaphthol enantiomer is researched, extraction solvent, elution solvent, extraction time, elution time, the doping amount of the magnetic graphene and the like are optimized, the composite material has higher selective adsorption capacity for the binaphthol enantiomer, an ee value of the composite material can reach up to 74.8%, a whole adsorption process can be finished within three minutes, and the ee value of the composite material is not obviously lowered after the material is reused for seven times.

Description

technical field [0001] The invention relates to a separation material, in particular to a chiral MOF-magnetic graphene functional material and its preparation method and application. Background technique [0002] The separation of chiral compounds, especially chiral drugs, is of great significance in drug research and pharmaceutical industry development. For drugs containing chiral centers, their stereoisomers usually have very similar physical and chemical properties, and there are significant differences in the pharmacological activity, metabolic process, metabolic rate and toxicity of enantiomers in vivo, such as non-steroidal anti-inflammatory drugs Pain drug ibuprofen, its pharmacological activity is mainly produced by (S)-ibuprofen, (R)-ibuprofen not only has low activity, but also has toxic side effects, so some manufacturers in the world have or are using Ibuprofen is marketed as an alternative to racemic ibuprofen. At present, the preparation methods of (S)-ibupro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/22B01J20/30B01J20/28C07C37/82C07C39/14
CPCB01J20/06B01J20/103B01J20/20B01J20/226B01J20/28009B01J2220/46B01J2220/4806B01J2220/4812C07C37/82C07C39/14
Inventor 于阿娟周晓华杜文瑞高煜张书胜
Owner ZHENGZHOU UNIV
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