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Detection kit for detecting hereditary thrombophilia related gene group

A detection kit and technology for thrombophilia, applied in the field of molecular biology, can solve the problems of low accuracy of diagnostic methods for hereditary thrombophilia and limitations of diagnostic methods for hereditary thrombophilia, and achieve high detection efficiency and high detection efficiency. high yield effect

Inactive Publication Date: 2017-04-26
天津见康华美医学诊断技术有限公司
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Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides a detection kit for detecting gene groups related to hereditary thrombophilia, so as to solve the limitation of the diagnostic methods of hereditary thrombophilia in the prior art, and the lack of knowledge from molecular biology. Diagnosis of hereditary thrombophilia from a medical point of view
[0006] Another technical problem to be solved by the present invention is that the accuracy of the diagnostic method of hereditary thrombophilia in the prior art is low

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  • Detection kit for detecting hereditary thrombophilia related gene group
  • Detection kit for detecting hereditary thrombophilia related gene group
  • Detection kit for detecting hereditary thrombophilia related gene group

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[0028] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0029] Materials and methods:

[0030] Among the patients diagnosed from August 2016 to December 2016 at Hematology Hospital of Chinese Academy of Medical Sciences and Union Medical Diagnostic Center, according to the following criteria, we performed continuous enrollment (11 patients).

[0031] The inclusion criteria are: patients diagnosed with thrombophilia or abnormal thrombus formation by clinical symptoms and coagulation-related laboratory tests, and clinicians need to perform genetic testing to confirm whether they are hereditary thrombophi...

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Abstract

The invention discloses a sequencing kit for screening hereditary thrombophilia related gene mutation, and a subsequent medical science interpreting database. A hereditary thrombophilia related gene group comprises SERPINC1, SERPIND1 and other seven genes. The sequencing kit comprises multiple PCR primers for amplifying all exons and relevant areas of the nine hereditary thrombophilia related genes. The kit for screening hereditary thrombophilia related gene mutation has the advantages of high detection efficiency, wide mutation gene coverage and high detection rate; and a medical science interpreting report given by the invention is accurate and authoritative.

Description

technical field [0001] The invention relates to the technical field of molecular biology, and further relates to a detection kit for screening gene mutations related to hereditary thrombophilia and a medical interpretation database thereof, in particular to a detection kit for detecting gene groups related to hereditary thrombophilia. Background technique [0002] Thrombophilia refers to the presence of genetic or acquired defects in anticoagulant proteins, coagulation factors, and fibrinolytic proteins, or the presence of acquired risk factors that lead to a high tendency to thromboembolism. The main type of thromboembolism in thrombophilia is venous thromboembolism (VTE). [0003] Hereditary thrombophilias mainly include abnormalities of congenital anticoagulant proteins, coagulation factors, and fibrinolytic proteins, while acquired thrombophilias are mainly thrombophilic symptoms caused by acquired thrombophilic diseases or acquired thrombophilic factors . At present, ...

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
Inventor 张冬雷贾玉娇李静寇坤元
Owner 天津见康华美医学诊断技术有限公司
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