A preparation method of composite hard sheet for tropical blister packaging

A technology of blister packaging and composite hard sheet, applied in the field of pharmaceutical packaging, can solve the problems of high cross-linking density, low production efficiency, easy contamination of finished products, etc., and achieve good mechanical properties, good curing effect and good compatibility.

CN106696427BActive Publication Date: 2018-07-20JIANGSU ZHENMEI PACKAGING TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2018-07-20

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Abstract

The invention relates to a preparation method of a composite hard sheet for tropical bubble cap package. The preparation method comprises the specific steps that a mixture of titanium dioxide, ytterbium fluoride and zirconia is calcined after being ball-milled to obtain a filler; dihexylamine and the filler are mixed, and then N-formyl morpholine, diethyl phosphonate and benzimidazole are mixed; diisoprene bicyclo oxide, polyamide and ethoxylated trimethylolpropane triacrylate are sequentially added into the mixture, and stirring is performed at the temperature of 170 DEG C for 5 minutes to obtain a compound; the compound is added to an extruder; then, a polyester film with the surface subjected to corona treatment is prepared into a composite polyester film through the extruder; the composite polyester film and an aluminum foil are subjected to hot-pressing compounding to obtain an aluminum plastic material; then the aluminum plastic material is prepared into the composite hard sheet for tropical bubble cap package through the extruder. The raw materials adopted in the preparation method are wide in source, the preparation process is simple and controllable, only conventional operation is needed, and industrialization is easy.
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Description

technical field

[0001] The invention belongs to the technical field of medicine packaging, and in particular relates to a preparation method of a composite hard sheet for tropical-type blister packaging. Background technique

[0002] In the pharmaceutical packaging industry, aluminum-plastic blister packaging is widely used, that is, PVC hard sheet is heated, blown into shape, filled with medicine, and then heat-sealed with aluminum foil; this packaging is easy to carry and easy to take, and is favored by most patients. favorite. However, due to the poor barrier properties of PVC hard sheets, the shelf life of drugs is very short, and the storage period of drugs generally cannot exceed two years due to hygroscopicity. Add an aluminum cover on the PVC side of the aluminum-plastic packaging to prepare aluminum-plastic-aluminum packaging, also known as tropical blister aluminum packaging, commonly known as tropical aluminum, which can extend the shelf life of drugs by utilizin...

Examples

Embodiment 1

[0024] Mix 40g of di-n-hexylamine and 100g of filler for 1 hour, then add 10g of N-formylmorpholine, 90g of diethyl phosphinate and 20g of benzimidazole, and mix for 2 hours to obtain a mixture; Add oxide, 30g polyamide wax, 80g ethoxylated trimethylolpropane triacrylate to the mixture, stir at 170°C for 5 minutes to obtain a compound; put the compound into the extruder; then corona treat the surface The finished polyester film passes through the extruder, and the compound is coated on the treated polyester film by the extrusion die, and then heat-baked to prepare a composite polyester film; the composite polyester film and aluminum foil are laminated by hot pressing, The aluminum-plastic material is obtained; the aluminum-plastic material is passed through an extruder, and the compound is coated on the aluminum surface of the aluminum-plastic material by an extrusion die, and then heat-baked to prepare a composite hard sheet for tropical blister packaging. It can be cut and p...

Embodiment 2

[0026] Mix 60g of di-n-hexylamine and 150g of filler for 1 hour, then add 13g of N-formylmorpholine, 160g of diethyl phosphinate and 18g of benzimidazole, and mix for 2 hours to obtain a mixture; Add oxide, 50g polyamide wax, 80g ethoxylated trimethylolpropane triacrylate into the mixture, stir at 170°C for 5 minutes to obtain a compound; put the compound into the extruder; then corona treat the surface The finished polyester film passes through the extruder, and the compound is coated on the treated polyester film by the extrusion die, and then heat-baked to prepare a composite polyester film; the composite polyester film and aluminum foil are laminated by hot pressing, The aluminum-plastic material is obtained; the aluminum-plastic material is passed through an extruder, and the compound is coated on the aluminum surface of the aluminum-plastic material by an extrusion die, and then heat-baked to prepare a composite hard sheet for tropical blister packaging. It can be cut an...

Embodiment 3

[0028] Mix 50g of di-n-hexylamine and 110g of filler for 1 hour, then add 12g of N-formylmorpholine, 140g of diethyl phosphinate and 19g of benzimidazole, and mix for 2 hours to obtain a mixture; Add oxide, 40g polyamide wax, 70g ethoxylated trimethylolpropane triacrylate to the mixture, stir at 170°C for 5 minutes to obtain a compound; put the compound into the extruder; then corona treat the surface The finished polyester film passes through the extruder, and the compound is coated on the treated polyester film by the extrusion die, and then heat-baked to prepare a composite polyester film; the composite polyester film and aluminum foil are laminated by hot pressing, The aluminum-plastic material is obtained; the aluminum-plastic material is passed through an extruder, and the compound is coated on the aluminum surface of the aluminum-plastic material by an extrusion die, and then heat-baked to prepare a composite hard sheet for tropical blister packaging. It can be cut and ...