A preparation method of composite hard sheet for tropical blister packaging

Abstract

The invention relates to a preparation method of a composite hard sheet for tropical bubble cap package. The preparation method comprises the specific steps that a mixture of titanium dioxide, ytterbium fluoride and zirconia is calcined after being ball-milled to obtain a filler; dihexylamine and the filler are mixed, and then N-formyl morpholine, diethyl phosphonate and benzimidazole are mixed; diisoprene bicyclo oxide, polyamide and ethoxylated trimethylolpropane triacrylate are sequentially added into the mixture, and stirring is performed at the temperature of 170 DEG C for 5 minutes to obtain a compound; the compound is added to an extruder; then, a polyester film with the surface subjected to corona treatment is prepared into a composite polyester film through the extruder; the composite polyester film and an aluminum foil are subjected to hot-pressing compounding to obtain an aluminum plastic material; then the aluminum plastic material is prepared into the composite hard sheet for tropical bubble cap package through the extruder. The raw materials adopted in the preparation method are wide in source, the preparation process is simple and controllable, only conventional operation is needed, and industrialization is easy.

Description

technical field [0001] The invention belongs to the technical field of medicine packaging, and in particular relates to a preparation method of a composite hard sheet for tropical-type blister packaging. Background technique [0002] In the pharmaceutical packaging industry, aluminum-plastic blister packaging is widely used, that is, PVC hard sheet is heated, blown into shape, filled with medicine, and then heat-sealed with aluminum foil; this packaging is easy to carry and easy to take, and is favored by most patients. favorite. However, due to the poor barrier properties of PVC hard sheets, the shelf life of drugs is very short, and the storage period of drugs generally cannot exceed two years due to hygroscopicity. Add an aluminum cover on the PVC side of the aluminum-plastic packaging to prepare aluminum-plastic-aluminum packaging, also known as tropical blister aluminum packaging, commonly known as tropical aluminum, which can extend the shelf life of drugs by utilizin...

AI Technical Summary

Problems solved by technology

However, there are defects in the existing tropical aluminum, especially when it is heat-sealed with PVC, a temperature as high as 180 degrees is required, resulting in a change in the properties of the drug, which may affect the safety of taking it; moreover, the existing adhesives are all solvent-based, which not only reduces production Low cost, easy pollution of finished products, and it is also unfavorable to the environment, especially the release of solvents that affect the properties of drugs

[0004] Epoxy resin has excellent adhesion, thermal stability and excellent chemical resistance. As a resin matrix for adhesives, coatings and composite materials, it is widely used in water conservancy, transportation, machinery, electronics, home appliances, automobiles and aerospace However, epoxy resin contains a large number of epoxy groups, and after curing, it has high crosslinking density, brittle texture, poor weather resistance and heat and humidity resistance, so it is difficult to meet the requirements of engineering technology, and its application is subject to certain restrictions.

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