Biflavone-iron complex and its preparation method and application

A technology of iron complexes and bisflavonoids, which is applied to iron organic compounds, iron group organic compounds without C-metal bonds, pharmaceutical formulations, etc., can solve problems such as unreported research on the synthetic biological activity of bisflavonoid complexes
CN106883272BInactive Publication Date: 2019-06-18NANJING FORESTRY UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING FORESTRY UNIV
Publication Date
2019-06-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a biflavone-iron complex, a preparation method and an application thereof. In the present invention, the biflavone-iron complex is obtained by reacting the biflavone-iron complex with the biflavone as the ligand and the iron ion as the central ion, and the structure of the complex is characterized by infrared spectrum, ultraviolet-visible absorption spectrum and high-resolution mass spectrum. At the same time, the present invention studies the anti-tumor and anti-oxidation activities of the biflavone-iron complex of Spiny chinensis. The MTT method showed that the amiflavone-iron complex of A. spiconia had good anti-tumor activity, and the anti-tumor activity was stronger than that of a. The antioxidative activity is stronger than the biflavone itself. The formation of biflavonoid-iron complexes improves the antitumor and antioxidative activities of biflavonoids in Spirocarpus, which is expected to be used in the development of drugs.
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Description

technical field

[0001] The invention belongs to the technical fields of organic synthesis and medicine, and specifically relates to a bisflavone-iron complex and its preparation method and application. Background technique

[0002] Biflavonoids are unique chemical components of gymnosperms, such as Ginkgo biloba and Selaginella, which have biological activities such as anti-oxidation, anti-inflammation, anti-virus, and anti-tumor. Among them, Amentoflavone (Amentoflavone, Ame) is a relatively common type of amentoflavone compounds, and its structural formula is as follows:

[0003]

[0004] Sun et al. found that amentoflavone increased the expression of anti-cancer genes by activating hPPARγ, thereby achieving the effect of inhibiting breast cancer cells and cervical cancer cells [Lee E., Shin S., Lee J. et al. Cytotoxic activities of amentoflavone against human Breast and cervical cancers are mediated by increasing of pten expression levels due to peroxisome proliferato...

Claims

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