Biflavone-iron complex and its preparation method and application
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A technology of iron complexes and bisflavonoids, which is applied to iron organic compounds, iron group organic compounds without C-metal bonds, pharmaceutical formulations, etc., can solve problems such as unreported research on the synthetic biological activity of bisflavonoid complexes
Inactive Publication Date: 2019-06-18
NANJING FORESTRY UNIV
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Problems solved by technology
[0006] However, so far, the research on the synthesis and biological activity of biflavone complexes has not been reported
Method used
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Embodiment 1
[0039] Accurately weigh 53.8mg of Ame in a round bottom flask, dissolve it with 5mL of ethanol, accurately weigh 20.2mg of ferric nitrate nonahydrate, dissolve it with 5mL of ethanol, add the ferric nitrate solution to the Ame solution dropwise, and add ethanol dropwise to the reaction solution -Ammonia water (V / V, 3:1) solution, adjust the pH to 6, keep at 30°C for 4-5h, precipitate, filter, wash with ethanol and water in turn, recrystallize in DMSO, and freeze-dry to obtain the Ame-Fe complex .
Embodiment 2
[0041] Accurately weigh 53.8 mg of Ame in a round bottom flask, dissolve it with 5 mL of 90% ethanol, accurately weigh 20.2 mg of ferric nitrate nonahydrate, dissolve it with 5 mL of 90% ethanol, add the ferric nitrate solution dropwise to the Ame solution, and add to the reaction solution Add ethanol-sodium ethoxide solution dropwise to adjust the pH to 5, keep at 30°C for 4-5h, precipitate, filter, wash with ethanol and water successively, recrystallize in DMSO, and freeze-dry to obtain the Ame-Fe complex.
Embodiment 3
[0043] Accurately weigh 53.8mg of Ame in a round bottom flask, dissolve it with 5mL of methanol, accurately weigh 20.2mg of ferric nitrate nonahydrate, dissolve it with 5mL of methanol, add the ferric nitrate solution to the Ame solution dropwise, and add methanol dropwise to the reaction solution - Sodium methoxide solution, adjust the pH to 7, keep at 40°C for 3-4 hours to react, a precipitate occurs, filter, wash with methanol and water successively, recrystallize in DMSO, and freeze-dry to obtain the Ame-Fe complex.
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Abstract
The invention discloses a biflavone-iron complex, a preparation method and an application thereof. In the present invention, the biflavone-iron complex is obtained by reacting the biflavone-iron complex with the biflavone as the ligand and the iron ion as the central ion, and the structure of the complex is characterized by infrared spectrum, ultraviolet-visible absorption spectrum and high-resolution mass spectrum. At the same time, the present invention studies the anti-tumor and anti-oxidation activities of the biflavone-iron complex of Spiny chinensis. The MTT method showed that the amiflavone-iron complex of A. spiconia had good anti-tumor activity, and the anti-tumor activity was stronger than that of a. The antioxidative activity is stronger than the biflavone itself. The formation of biflavonoid-iron complexes improves the antitumor and antioxidative activities of biflavonoids in Spirocarpus, which is expected to be used in the development of drugs.
Description
technical field [0001] The invention belongs to the technical fields of organic synthesis and medicine, and specifically relates to a bisflavone-iron complex and its preparation method and application. Background technique [0002] Biflavonoids are unique chemical components of gymnosperms, such as Ginkgo biloba and Selaginella, which have biological activities such as anti-oxidation, anti-inflammation, anti-virus, and anti-tumor. Among them, Amentoflavone (Amentoflavone, Ame) is a relatively common type of amentoflavone compounds, and its structural formula is as follows: [0003] [0004] Sun et al. found that amentoflavone increased the expression of anti-cancer genes by activating hPPARγ, thereby achieving the effect of inhibiting breast cancer cells and cervical cancer cells [Lee E., Shin S., Lee J. et al. Cytotoxic activities of amentoflavone against human Breast and cervical cancers are mediated by increasing of pten expression levels due to peroxisome proliferato...
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