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A bone marrow mesenchymal stem cell-derived exosome with anti-liver cancer effect and its pharmaceutical preparation

A technology of bone marrow mesenchyme and exosomes, applied in bone/connective tissue cells, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as liver cancer treatment drugs that do not meet clinical needs

Active Publication Date: 2020-06-23
中科聚研(吉林)干细胞科技有限公司
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Problems solved by technology

[0005] At present, drugs for the treatment of liver cancer are far from meeting the clinical needs, and this market also contains huge potential value

Method used

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  • A bone marrow mesenchymal stem cell-derived exosome with anti-liver cancer effect and its pharmaceutical preparation
  • A bone marrow mesenchymal stem cell-derived exosome with anti-liver cancer effect and its pharmaceutical preparation
  • A bone marrow mesenchymal stem cell-derived exosome with anti-liver cancer effect and its pharmaceutical preparation

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Embodiment Construction

[0023] The substantive content of the present invention will be specifically introduced below in conjunction with the embodiments. Due to space reasons, the description of the experimental process cannot be done in great detail. All the parts not described in detail in the experiment are routine operations well known to those skilled in the art.

[0024] 1. Experimental materials

[0025] The pyridoimidazole organic compounds numbered CM1-6 are all known compounds, which were synthesized by our company's synthesizers referring to the literature and conventional methods of organic synthesis, and confirmed by mass spectrometry and NMR.

[0026] RPMI1640 medium, high-glucose DMEM medium, α-MEM medium and newborn bovine serum were purchased from Gibco; human liver cancer SMMC-7721 was provided by Nanjing Medical University. BALB / C nude mice, male, 4-6 weeks old, with a body weight of 18-22 g, were provided by the Animal Experiment Center of Nanjing University. Exosome rapid extra...

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Abstract

The invention discloses an exosome serving as a mesenchymal stem cell source and having an anti-cancer effect and a medicinal preparation thereof. The medicinal preparation is prepared from the exosome serving as the mesenchymal stem cell source by loading compounds; the compounds are pyridine imidazole organic compounds with a structure in the following general formula; and loading means import of the compounds into the exosome. An experimental result shows that the exosome serving as the mesenchymal stem cell source can inhibit proliferation of hepatoma carcinoma cells both in vivo and in vitro, but is relatively weak in inhibiting effect; however, after the exosome serving as the mesenchymal stem cell source is subjected to loading of the compounds CM1 to 6, the inhibiting effect on proliferation of hepatoma carcinoma cells in vivo and in vitro is obviously improved, the medicine effect is excellent, and the exosome serving as the mesenchymal stem cell source can be used for preparing a medicament for treating the liver cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to exosome-based therapeutic drugs, in particular to an exosome derived from bone marrow mesenchymal stem cells with an anti-liver cancer effect and a pharmaceutical preparation thereof. Background technique [0002] Exosomes were first discovered in the supernatant of sheep red blood cells cultured in vitro. They are vesicle-like bodies actively secreted by cells with a uniform size, a diameter of 40-100nm, and a density of 1.10-1.18g / ml. In 1996, some scholars discovered that B cells can promote T cell proliferation and inhibit tumor growth by releasing exosomes expressing major histocompatibility complex (MHC) molecules. Exosomes contain a variety of proteins and genetic material, suggesting that macromolecules such as proteins can be loaded onto exosomes. Exosomes can be widely distributed in different body fluids and have a long half-life in the body. In addition, exosomes can penetra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/28A61K31/437A61P35/00C12N5/0775
CPCA61K31/437A61K35/28C12N5/0663A61K2300/00
Inventor 王莉张艳峰徐梦龙
Owner 中科聚研(吉林)干细胞科技有限公司
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