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A kind of silicone gel for removing scars and preparation method thereof

A technology for silicone gel and scar removal, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory, difficult absorption, etc. Uses, smoothes and softens scars, improves scar pigmentation

Active Publication Date: 2020-11-06
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing silicone gel products are relatively greasy and are not easily absorbed after application. They are often unsatisfactory in terms of scar pigmentation, improvement of scar itching, erythema, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A silicone gel for removing scars, prepared from the following raw materials in parts by weight: 5 parts of dimethyl silicone oil, 10 parts of hexamethyldisiloxane, 60 parts of polydimethylsiloxane self-crosslinking polymer 2 parts, 2 parts of Moutan cortex extract, 3 parts of aloe-emodin, 2 parts of matrine, and 3 parts of calamine; among them, Moutan cortex extract, aloe-emodin and matrine are all oily extracts; polydimethyl The molecular weight of the silicone self-crosslinking polymer is 8000.

[0017] The preparation method of the above-mentioned scar-removing silicone gel includes taking simethicone oil, hexamethyldisiloxane, and polydimethylsiloxane self-crosslinked polymer in parts by weight and mixing them evenly, and then adding the extract of Moutan Cortex , aloe-emodin, matrine and calamine, stir evenly, fill in medical aluminum-plastic packaging tubes, and the product is completed.

Embodiment 2

[0019] A silicone gel for removing scars, prepared from the following raw materials in parts by weight: 1 part of dimethyl silicone oil, 30 parts of hexamethyldisiloxane, 20 parts of polydimethylsiloxane self-crosslinking polymer 2 parts of Cortex Moutan Extract, 4 parts of Aloe-Emodin, 3 parts of Matrine, and 5 parts of Calamine; Among them, Cortex Moutan Extract, Aloe-Emodin and Matrine are all oily extracts; polydimethyl The molecular weight of the silicone self-crosslinking polymer is 10,000.

[0020] The preparation method of the above-mentioned scar-removing silicone gel includes taking simethicone oil, hexamethyldisiloxane, and polydimethylsiloxane self-crosslinked polymer in parts by weight and mixing them evenly, and then adding the extract of Moutan Cortex , aloe-emodin, matrine and calamine, stir evenly, fill in medical aluminum-plastic packaging tubes, and the product is completed.

Embodiment 3

[0022] A silicone gel for removing scars, prepared from the following raw materials in parts by weight: 10 parts of dimethyl silicone oil, 15 parts of hexamethyldisiloxane, 45 parts of polydimethylsiloxane self-crosslinking polymer 5 parts of Moutan cortex extract, 3 parts of aloe-emodin, 2 parts of matrine, and 2 parts of calamine; among them, Moutan cortex extract, aloe-emodin and matrine are all oily extracts; polydimethyl The molecular weight of the silicone self-crosslinking polymer is 20,000.

[0023] The preparation method of the above-mentioned scar-removing silicone gel includes taking simethicone oil, hexamethyldisiloxane, and polydimethylsiloxane self-crosslinked polymer in parts by weight and mixing them evenly, and then adding the extract of Moutan Cortex , aloe-emodin, matrine and calamine, stir evenly, fill in a plastic tube, and it's done.

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Abstract

The invention relates to the technical field of biological medicines and particularly relates to a silicone gel capable of removing a scar and a preparation method of the silicone gel. The silicone gel is prepared from the following raw materials in parts by weight: 1-10 parts of dimethyl silicone oil, 10-30 parts of hexamethyldisiloxane, 20-60 parts of a polydimethylsiloxane self-crosslinking polymer, 0-10 parts of a natural plant antimicrobial agent and 0-5 parts of an antipruritic agent. The dimethyl silicone oil and the polydimethylsiloxane self-crosslinking polymer can be quickly crosslinked and combined with other components under the action of the hexamethyldisiloxane and the hexamethyldisiloxane has high volatility, is capable of quickly promoting various substances to form a thin film after being crosslinked and combined, and is well tightly laminated with epidermis; hydration of skin is ensured; the silicone gel has the effects of smoothing and softening scars caused by various external causes; and meanwhile, various components work together, so that scar hyperpigmentation is significantly improved and the symptoms such as pruritus and erythema are improved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a scar-removing silicone gel and a preparation method thereof. Background technique [0002] Scar is a kind of compensatory incomplete regeneration that cannot fully achieve histological regeneration after the body is damaged, and is replaced by connective tissue. It is essentially a kind of abnormal and unsound tissue that does not have normal skin structure and function. . Burns, scalds, and surgical operations are the main causes of hypertrophic scars in skin tissue. At the same time, factors such as collagen metabolism imbalance, contraction of myofibroblasts, and changes in dermal extracellular matrix components can also cause hypertrophic scars. [0003] Silicone gel is the first-line product recommended by global medical experts to treat scars, which can create an ideal environment for scars. In addition, silicone gel has the characteristics of low permeability to wa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K36/65A61K9/06A61P17/02A61K31/122A61K31/4375A61K33/30
CPCA61K9/0014A61K9/06A61K31/122A61K31/4375A61K33/30A61K36/65A61K36/71A61K47/34A61K2300/00
Inventor 张艳琦周新钦刘尧高勇
Owner HENAN HUIBO MEDICAL CO LTD
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