Pharmaceutical composition for treating granulation tissue hyperplasia around orifice of central venous indwelling catheter

A composition and drug technology, applied in the directions of drug combination, cardiovascular system diseases, antipyretic drugs, etc., to achieve the effects of alleviating pain and inhibiting the proliferation of granulation tissue

Inactive Publication Date: 2017-07-28
THE SECOND HOSPITAL OF SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no report on the treatment of granulation tissue hyperplasia around the orifice of central venous indwelling catheter with Xihuangcao and Digupi

Method used

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  • Pharmaceutical composition for treating granulation tissue hyperplasia around orifice of central venous indwelling catheter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of Xihuangcao extract:

[0030] Grind Xihuangcao, pass through a 80-100 mesh sieve, add ethanol solution with a volume fraction of 95%, the ratio of Xihuangcao to ethanol solution is 1g:10ml; ultrasonic extraction, the power of ultrasonic extraction is 300W, ultrasonic extraction The time is 30min; the extract is obtained, the extract is concentrated and dried to obtain the Xihuangcao extract.

[0031] (2) Preparation of Digupi extract

[0032] Crush the Cortex Lycii, add 10 times the weight of water to reflux and extract 3 times, each time for 1.5 hours, filter, and combine the extracts; concentrate the extracts to a relative density of 1.10-1.20 (measured at 50°C) to obtain a concentrated solution;

[0033] The concentrated solution was added to the D101 macroporous adsorption resin column, first eluted with 5 times the column volume of water, and then 10 times the volume fraction of the column volume with 50% ethanol, collected the ethanol eluate, re...

Embodiment 2

[0037] The preparation method of Xihuangcao extract and Digupi extract is the same as that in Example 1.

[0038] The Xihuangcao extract and Digupi extract are mixed at a weight ratio of 3:1 to obtain a pharmaceutical composition for treating granulation tissue hyperplasia around the orifice of a central venous indwelling catheter.

[0039] Then the pharmaceutical composition is combined with pharmaceutical excipients to make a gel by conventional methods.

Embodiment 3

[0041] The preparation method of Xihuangcao extract and Digupi extract is the same as that in Example 1.

[0042] The Xihuangcao extract and Digupi extract are mixed at a weight ratio of 1:1 to obtain a pharmaceutical composition for treating granulation tissue hyperplasia around the orifice of a central venous indwelling catheter.

[0043] Then the pharmaceutical composition is combined with pharmaceutical excipients to make a gel by conventional methods.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating granulation tissue hyperplasia around the orifice of a central venous indwelling catheter. The pharmaceutical composition comprises extract of Rabdosia serra and extract of cortex lycii radicis according to a weight ratio of (1: 3): 1. Through combination of extract of Rabdosia serra and extract of cortex lycii radicis, granulation tissue hyperplasia around the orifice of a central venous indwelling catheter is inhibited so that patient pain is reduced and a clinical promotion and use value is obtained.

Description

technical field [0001] The invention relates to a medicinal extract composition for treating granulation tissue hyperplasia around the orifice of a central venous indwelling catheter, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Central venous catheter is one of the main vascular access in hemodialysis patients. The central venous catheter without tunnel and polyester sleeve is the preferred vascular access for primary dialysis, rescue of poisoning, acute renal failure, and immature arteriovenous fistula. The main catheterization sites are internal jugular vein, subclavian vein, and femoral vein. In clinical practice, the indwelling time of such catheters usually ranges from several days to several months. During the indwelling catheter period, some patients have granulation tissue hyperplasia around the orifice of the central venous catheter, manifested as pain to the touch. During daily activities and receiving nursing o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P29/00A61P9/00
CPCA61K36/53A61K36/815A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 胡桂钰韩颖厉淑荣肖合存王会
Owner THE SECOND HOSPITAL OF SHANDONG UNIV
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