Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A near-infrared laser-driven mitochondria-targeted fluorescent polymer and its preparation method and application

A fluorescent polymer and laser-driven technology, applied in photodynamic therapy, chemical instruments and methods, medical preparations of non-active ingredients, etc., can solve the problems of small diffusion range and short lifespan of photosensitizers

Active Publication Date: 2019-04-16
深圳市丰用实业集团有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional photosensitizers have short lifetime, small diffusion range, easy aggregation-induced quenching effect, and most of the excitation light is ultraviolet light or visible light with shallow tissue permeability.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A near-infrared laser-driven mitochondria-targeted fluorescent polymer and its preparation method and application
  • A near-infrared laser-driven mitochondria-targeted fluorescent polymer and its preparation method and application
  • A near-infrared laser-driven mitochondria-targeted fluorescent polymer and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0068] A near-infrared laser-driven mitochondria-targeting fluorescent polymer, the compound name is poly(2Z,2'Z)-3,3'-(2,5-bis(diphenylamino)-1,4-phenyl) Bis(2-(3,5-bis(trifluoromethyl)phenyl)acrylonitrile-co(N-(2-hydroxypropyl)methacrylamide)-co(2-aminoethyl methacrylate) ) polymer (PAIE-TPP), emits red fluorescence under the irradiation of an ultraviolet lamp with a wavelength of 365nm, and the molecular structural formula of the compound PAIE-TPP is:

[0069]

[0070] Its preparation method, the steps are as follows:

[0071] 1) In a 100mL round bottom flask, mix 0.3300g (1.130mmol) of 1,4-dibromo-2,5-diformylbenzene, 0.5718g (2.260mmol of 3,5-bis(trifluoromethyl)benzene with Mix 20mL absolute ethanol evenly to obtain a mixed solution;

[0072] 2) Dissolve 6.0g (16.70mmol) NaOH in 10mL absolute ethanol to obtain NaOH-ethanol solution;

[0073]3) Using a constant pressure low liquid funnel, under N 2 Under protection, NaOH-ethanol solution was added dropwise to the m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed is a near infrared laser-driven mitochondrial targeting fluorescent polymer and a preparation method and application thereof. A nano-scale photosensitizer, which is prepared from a polymer of poly-(2Z, 2'Z)-3,3'-(2, 5-bis(diphenylamino)-1, 4-phenyl) bis(2-(3, 5-bis(trifluoromethyl) phenyl) acrylonitrile-copolymer (N-(2-hydroxypropyl) methacrylamide)-copolymer (2-dimethylamino ethyl methacrylate) and an inorganic upconversion nano-scale particle of ytterbium and thulium codoped sodium yttrium fluoride in aqueous solution; when irradiated by laser of a wavelength of 980 nm, the nano-scale photosensitizer can produce reactive oxygen to effectively kill cells. The invention provides a novel and effective nano-scale photosensitive material for research and application of photodynamic therapy of tumor cells in the future.

Description

technical field [0001] The invention relates to a photodynamic therapy technology based on a fluorescent photosensitizer, in particular to a method for preparing a nano photosensitizer driven by a near-infrared laser, highly aggregated, and targeted to mitochondria, which is an organic fluorescent polymer-coated inorganic upconversion nanoparticle. Background technique [0002] Photodynamic therapy, also known as photosensitization therapy and photochemotherapy, is a new technology for tumor treatment that was formed in the late 1970s. Photodynamic therapy is to irradiate the laser with a specific wavelength to excite the photosensitizer absorbed by the tissue, and the photosensitizer in the excited state transfers energy to the surrounding oxygen to generate highly active singlet oxygen, singlet oxygen and adjacent oxygen. Oxidation reaction of biomacromolecules occurs, resulting in cytotoxicity, which in turn leads to cell damage and even death. At present, it has been of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/58C08F220/34C08F8/40C09K11/02C09K11/06C09K11/85A61K41/00A61K9/51A61K47/32A61P35/00
CPCA61K9/5138A61K41/0057C08F8/40C08F220/58C09K11/02C09K11/06C09K11/7773C09K2211/1425C08F220/34
Inventor 吕宏光高辉关月
Owner 深圳市丰用实业集团有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com