A preparation method of targeting nano ginkgo starch microspheres loaded with urushiol
A technology of starch microspheres and ginkgo, which is applied in the directions of inactive medical preparations, pharmaceutical formulations, inorganic inactive ingredients, etc., can solve the problems of unstable urushiol structure, no urushiol loading, easy oxidative polymerization, etc. Improve the utilization rate and economic value, the effect of stable structure and uniform dispersion
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Embodiment 1
[0034] Separation of ginkgo starch
[0035] Shell fresh ginkgo, crush, soak in 0.3-0.5% dilute lye for 2-3 hours, homogenize, sieve, pour off the supernatant after standing, and then add 0.3-0.5% dilute lye Stir overnight with low-speed magnetic force, centrifuge to remove the upper layer and bottom residue, wash the starch 3 to 4 times, degrease with anhydrous methanol for 24 hours, and dry at 45°C for 48 to 72 hours to obtain ginkgo starch.
[0036] The chemical components in the ginkgo mainly include protein and starch. The lye can loosen the tight structure of the ginkgo starch combined with the ginkgo protein in the ginkgo. At the same time, the lye can destroy the hydrogen bonds in the protein molecules, causing some polar groups to form Dissociation causes the surface of the protein molecule to have the same charge, so that the protein dissolves in the lye and promotes the separation of starch and protein.
[0037] The present invention studies the influence of lye con...
Embodiment 2
[0042] Preparation of targeted nano ginkgo starch microspheres
[0043] Weigh a certain amount of ginkgo starch, add an appropriate amount of distilled water and mix thoroughly, control the concentration of starch milk to 8-12%, then adjust the pH value to 8-10 with 2mol / L KOH solution, place in a water bath at 80°C and stir until Transparent, after the solution is cooled, add 3-5% Fe of ginkgo starch mass 3 o 4 Ferrofluid, ultrasonically stirred evenly as water phase A; measure a certain volume of liquid paraffin and pour it into a three-necked flask, add an emulsifier with a mass of 10-14% of the liquid paraffin, and stir at 55°C for 10-30 minutes until fully mixed , as the oil phase B; add the prepared water phase A dropwise into the above oil phase B, control the volume ratio of the water phase A and the oil phase B to be 1:6~1:10, and maintain a uniform stirring speed for the emulsification reaction of 30~ After 60 minutes, add N,N'-methylene bisacrylamide crosslinking ...
Embodiment 3
[0051] Preparation of targeting nano-ginkgo starch microspheres loaded with urushiol
[0052] Prepare a urushiol solution with a mass volume percentage of 10-20% by using absolute ethanol or acetone as a solvent, and then add a certain amount of prepared targeting nano ginkgo starch microspheres to control the concentration of the targeting nano ginkgo starch microspheres and urushiol solution. The mass volume percentage of the solution is 3-6%, then vibrated and ultrasonicated for 1-2 hours, filtered with suction, washed with absolute ethanol, and dried with cold wind to obtain targeted nano ginkgo starch microspheres loaded with urushiol.
[0053] Urushiol is a natural anti-tumor active ingredient, but the structure of urushiol is unstable. When it is used alone as a drug, its bioavailability in vivo is poor, and it lacks tissue selectivity and has severe side effects. The present invention uses ginkgo starch as a raw material to prepare nano ginkgo starch microspheres, and ...
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