An artificial optic nerve cannula for experimental animals

Abstract

The invention provides an artificial optic nerve cannula for experimental animals, which is made of non-toxic and environmentally friendly polymethyl methacrylate, including an upper half-hollow cylinder and a lower half-hollow cylinder, an upper half-hollow cylinder and a lower half-hollow cylinder. One side of the cylinder is connected together by a connecting part, the center of the lower semi-hollow cylinder has a hemispherical protrusion, the upper semi-hollow cylinder is provided with an upper extension, and the upper extension is provided with two square holes, and the lower semi-hollow cylinder There is a lower extension part, and there are two buttons on the lower extension part. Put it on the optic nerve and buckle the buttons. The hemispherical protrusion can compress the optic nerve for a long time. By choosing different hemispherical protrusions, you can control the degree of compression. Controls were performed to quantify damage to the optic nerve.

Description

technical field [0001] The invention belongs to medical model appliances, in particular to an artificial optic nerve cannula used for animal experiments. Background technique [0002] Indirect traumatic optic neuropathy (Indirect traumatic optic neuropathy, ITON) is mainly caused by the severe damage of the optic nerve function after the outer and upper frontotemporal part of the orbital brow arch is suddenly hit by external blunt force, and the vast majority of patients show a sharp decline in vision after injury , or even completely lost. According to statistics, ITON accounts for about 5% of closed craniocerebral injuries. With the rapid development of industry, mining, transportation, and tourism, the incidence of ITON is increasing in my country, and it has become a common serious ocular trauma. [0003] The pathogenesis of ITON includes three aspects. One is that the instantaneous external force indirectly acts on the optic nerve, resulting in nerve damage. The other ...

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Problems solved by technology

[0004] In order to put pressure on the optic nerve, the patent application number CN200820155530.3 provides an automatic quantitative injury equipment for the peripheral nerves of experimental animals, which uses motor control to accurately pressurize the optic nerve cannula. Although this method is accurate and quantitative, it is only for a short time. The damage to the optic nerve cannot simulate the long-term high pressure state of the optic nerve after ITON; the article in the 283-285 pages of the Chinese Journal of Ocular Trauma and Occupational Eye Diseases, Issue 4, 1998: Provides a kind of optic nerve impact injury in the morphological study of retinal structure caused by optic nerve injury In the animal model, the optic nerve at the apex of the orbital apex of guinea pigs is surgically exposed, and a wooden bar with a blunt round head is placed vertically above the optic nerve. Indirect impact injury, although this method acts on the optic nerve cannula, it can cause long-term high pressure in the cannula, but due to the different skull strength of each animal, the damage to the optic nerve is not quantifiable

Therefore, none of the current technologies can fully meet these three conditions. It is necessary to design a model that can simultaneously meet the requirements of manufacturing extrusion pressure acting on the optic nerve, quantify / grading the pressure, and simulating the high pressure state in the tube of the local optic nerve.

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