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CD4-positive TH17T cell culture method

A cell culture and cell technology, applied in the direction of cell culture active agent, tissue culture, animal cells, etc., can solve the problems of insufficient yield and insufficient tumoricidal activity, and achieve the effect of sufficient quantity, strong anti-aging properties, and improved clinical effect.

Inactive Publication Date: 2017-10-17
湖南未名三胞转化医学科技有限公司
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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for culturing T cells, in particular to a method for culturing CD4-positive TH17T cells, to replace

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  • CD4-positive TH17T cell culture method

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Abstract

The invention provides a CD4-positive TH17T cell culture method, and aims to replace clinically existing CD8T cells through TH17T cells. Compared with the CD8T cells, the TH17T cells can actively proliferate for up to 21 days in vitro without secondary stimulating so as to generate 5,000 times number of T cells for use. Therefore, sufficient number is ensured. In addition, the stem cell characteristics of the TH17 cells enable the Th17 cells to have high anti-aging characteristics; strong capacity to remove a tumour in vivo is still remained after two-week proliferation in vitro, so that the clinical effect is greatly improved.

Description

technical field [0001] The invention is applied in the field of cells and cell therapy, and specifically relates to a cell culture method, in particular to a CD4 positive TH17T cell culture method. Background technique [0002] Immunotherapy offers an attractive approach to cancer treatment with the advantage of enhancing or rebuilding patients' antitumor immunity with fewer side effects. Two main strategies have been used to stimulate antitumor immunity. Including tumor therapeutic vaccines and adoptive cell therapy (ACT). Among them, adoptive cell therapy mainly refers to the reinfusion of autologous or allogeneic immune cells into the tumor-bearing host, such as CTL with tumor-reactive T cells as the main component ( cytotoxic T lymphocyte) cells, tumor-infiltrating lymphocytes (tumor-infiltrating lymphocyte, TIL) and so on. The reinfusion of tumor-reactive CTL cells has been successfully applied in the clinical treatment of melanoma, Epstein-Barr virus-induced lymphoma...

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IPC IPC(8): C12N5/0783
CPCC12N5/0635C12N2501/2301C12N2501/2304C12N2501/2306C12N2501/2323C12N2501/24C12N2501/51C12N2501/515
Inventor 罗超曾明哲高守泉
Owner 湖南未名三胞转化医学科技有限公司