Novel purpose of pteris multifida poir general flavone

A technology of anchovy and total flavonoids is applied in the directions of medical preparations containing active ingredients, preparations for in vivo experiments, medical raw materials derived from ferns/filamentous plants, etc., to reduce blood lipids, improve prevention and treatment Good effect on prevention and treatment of atherosclerosis

Inactive Publication Date: 2017-10-20
苏州华测生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of total flavonoids of Pteris flavonoids in reducing blood lipid or anti-atherosclerosis has not been reported so far

Method used

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  • Novel purpose of pteris multifida poir general flavone
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  • Novel purpose of pteris multifida poir general flavone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of the total flavonoids of embodiment 1 Pteris vulgaris

[0014] According to the above-mentioned publication number, it is prepared according to the process of CN1555869 Patent Document Example 1, that is, 3 kilograms of Pteris vulgaris is dynamically extracted twice with 300 kilograms of 70% ethanol, the extract is collected, concentrated in vacuum, petroleum ether extracts fat-soluble impurities, and water After passing through the macroporous resin column, after the water liquid is loaded on the column to reach saturation, the hydrophilic impurities are washed away with water and 30% ethanol, the flavonoid glycosides are eluted with 50% ethanol, the eluate is dried, and refined with an organic solvent once to obtain phoenix Total flavonoids of tail grass.

[0015] Also can prepare the total flavonoids of Pteris flavonoids by the following process that the inventor uses, and preparation method is:

[0016] After soaking 5 kilograms of Pteris vulgaris...

Embodiment 2

[0017] Example 2 Effect of Oral Administration of Total Flavonoids of Pteris vulgaris on Blood Fat in Rats with Disordered Lipid Metabolism

[0018] 1.1 Preparation of test samples: Accurately weigh the total flavonoids prepared in Example 1 and use 0.5% CMC-Na to prepare suspensions with final concentrations of 2 mg / kg and 4 mg / kg respectively.

[0019] 1.2 Preparation of positive control substance: Accurately weigh atorvastatin, add 0.5% CMC-Na to prepare a suspension with a concentration of 2 mg / kg, and set aside.

[0020] 1.3 Test method: 30 male SD rats, weighing 170-180 g, were fed adaptively for 3 days. The animals were stratified and divided into 4 groups according to their weight, with 6 rats in each group. The high-fat feed ratio is as follows: 10% lard, 2% cholesterol, 0.2% propylthiouracil, 0.5% pig bile salt, and 87.3% basal feed.

[0021] Table 1. Trial Grouping

[0022]

[0023] Animals were fed high-fat feed for modeling (except normal group) and given cor...

Embodiment 3

[0041] Example 3 The effect of total flavonoids of Pteris chinensis on rat atherosclerosis

[0042] 2.1 Preparation of the test sample: After accurately weighing the total flavonoids prepared in Example 1, use 0.5% CMC-Na to prepare a suspension with a final concentration of 4 mg / kg for future use.

[0043] 2.2 Positive control substance preparation: Accurately weigh simvastatin, add 0.5% CMC-Na to make a suspension with a concentration of 4 mg / kg, and set aside

[0044] 2.3 Test method: The animals were weighed after adaptive feeding for 3 days, and divided into groups evenly according to the body weight, with 10 animals in each group (see Table 4).

[0045] Table 4. Trial Grouping

[0046] group

number of animals

feeding feed

Dosage (mg / kg)

Dosing volume (ml / kg)

normal group

n＝8

Ordinary complete nutrition feed

----

----

model group

n＝8

high fat feed

0.5%CMC-Na

5

Total flavonoids of fern

n＝8

hig...

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Abstract

The invention discloses a novel purpose of pteris multifida poir general flavone in preparation of medicine for treating hyperlipemia and atherosclerosis. The lipid-lowering and anti-atherosclerosis effects are studied through a rat lipid metabolism disturbance model and an atherosclerosis model; study results prove that the pteris multifida poir general flavone can reduce the contents of TG, CHO and LDL-C in the rat blood serum; the H / L ratio is increased; the atherosclerotic plaque length and area can be reduced; good lipid-lowering and anti-atherosclerosis effects are achieved; the pteris multifida poir general flavone can be prepared into medicine applied to the aspect.

Description

technical field [0001] The invention relates to a new application of the total flavonoids of Pteris vulgaris, belonging to the technical field of new application of medicine. Background technique [0002] Pteris multifida Poir., also known as Pteris multifida Poir., is rich in resources in my country and has a history of thousands of years of application. Its "light taste, slightly bitter, cold in nature" ("Dictionary of Chinese Medicine"); "Herbal Medicine" says: "Treat all heat and poison. Reduce swelling and clear fire"; "Guizhou Folk Medicine Collection" says: "Antipyretic, diuretic"; Blood to stop bleeding, cure mainly stranguria, dysentery and other effects. The total flavonoids of Pteris flavonoids can inhibit the migration of human glioma U251 cells (Liu Yinfeng et al.: Journal of Chengde Medical College, 2014, 3l(2): 93-95), and have significant effects on prostatic hyperplasia in castrated rats induced by testosterone propionate. Therapeutic effect (Dai Guangche...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/12A61P3/06A61P9/10A61K49/00A01K67/02
CPCA01K67/02A61K36/12A61K49/0008A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 陆国才宗英夏玉叶郭美丽
Owner 苏州华测生物技术有限公司
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