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A microwave-assisted extraction method of three lactone compounds in Rhizoma Chuanxiong

A microwave-assisted, compound technology, applied in solid solvent extraction, chemical/physical/physical-chemical processes of applied energy, etc., can solve the problems of high viscosity, high cost, unfavorable dispersion and mass transfer, etc. The effect of small fluctuation and high extraction efficiency

Active Publication Date: 2019-10-22
DONGGUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

1) Traditional ionic liquids / functionalized ionic liquids generally have high viscosity, which is not conducive to dispersion and mass transfer. 3) At present, imidazole-based ionic liquids are mainly used for extraction, and the cost is relatively high. Therefore, it should be further found that the raw materials are cheap and easy to obtain , a new type of ionic liquid with simple synthesis process and suitable for large-scale industrial use;

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Take by weighing choline chloride and ethylene glycol (molar ratio 1:2) the deep eutectic solvent 30g that forms, and particle size is 60 mesh Rhizoma Chuanxiong powder 1g, under 800rpm magnetic stirring condition, reaction tube is put into microwave reactor, Connect the pressure-sensing tube and the temperature-sensing optical fiber, set the temperature to 160°C, and set the extraction time to 5 minutes. After the extraction was completed, after the sample was cooled to room temperature, the sample was diluted with methanol, filtered, then transferred to a volumetric flask, and constant volume was used with methanol. Utilize high-performance liquid chromatography, adopt internal standard method, measure three kinds of lactone compounds: ligustilide, ligustilide I and ligustilide H concentrations are respectively: 193.2mg / L, 15.5mg / L, 3.8mg / L L.

Embodiment 2

[0039]Take by weighing choline chloride and ethylene glycol (molar ratio 1:2) the deep eutectic solvent 20g that forms, and particle size is 80 mesh Rhizoma Chuanxiong powder 1g, under 600rpm magnetic stirring condition, put reaction tube into microwave reactor, Connect the pressure-sensing tube and the temperature-sensing optical fiber, set the temperature to 160°C, and set the extraction time to 1 min. After the extraction is finished, after the sample is cooled to room temperature, dilute the sample with a small amount of methanol, filter, then transfer it to a volumetric flask, and dilute to volume with methanol. Utilize high-performance liquid chromatography, adopt internal standard method, measure three kinds of lactone compounds: ligustilide, ligustilide I and ligustilide H concentrations are respectively: 123.5mg / L, 10.8mg / L, 2.6mg / L L.

Embodiment 3

[0041] Take by weighing choline chloride and ethylene glycol (molar ratio 1:2) the deep eutectic solvent 10g that forms, particle size is 160 mesh Rhizoma Chuanxiong powder 1g, under 1000rpm magnetic stirring condition, reaction tube is put into microwave reactor, Connect the pressure-sensing tube and the temperature-sensing optical fiber, set the temperature to 160°C, and set the extraction time to 1 min. After the extraction is finished, after the sample is cooled to room temperature, dilute the sample with a small amount of methanol, filter, then transfer it to a volumetric flask, and dilute to volume with methanol. Utilize high performance liquid chromatography, adopt internal standard method, measure three kinds of lactone compounds: ligustilide, ligustilide I and ligustilide H concentrations are respectively: 106.2mg / L, 8.7mg / L, 2.1mg / L L.

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Abstract

The invention relates to a microwave-assisted extraction method of three lactone compounds in rhizoma chuanxiong and belongs to the field of extraction separation. The microwave-assisted extraction method includes: allowing an extracting agent to contact with rhizoma chuanxiong powder, wherein the extracting agent is a deep eutectic solvent formed by choline chloride and acetic acid, propionic acid or ethylene glycol according to the mole ratio of 1:1-1:5. The microwave-assisted extraction method has the advantages that ligustilide, senkyunolide I and senkyunolide H in the rhizoma chuanxiong powder can be extracted, the extraction efficiency of the lactone compounds can reach 180mg / L, and the method is high in extraction efficiency, high in selectivity, mild in operation condition and environmentally friendly.

Description

technical field [0001] The invention relates to a microwave-assisted extraction method for three lactone compounds in Rhizoma Chuanxiong, belonging to the field of extraction and separation. Background technique [0002] Natural products are potential raw material resources in drug research and development, and the separation and purification of substances with unique biological activities in natural products is an important basic work in the research of traditional Chinese medicine. Chuanxiong is the rhizome of Ligusticum Chuanxiong Hort. It is a commonly used traditional Chinese medicine for promoting blood circulation and removing blood stasis. It has unique curative effects on cardiovascular system, nervous system and other diseases. Among them, chuanxiong lactones, as very important chemical components in Chuanxiong, can play the role of promoting blood circulation and removing stasis. However, the active components in Rhizoma Chuanxiong are complex, and the content is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D11/02B01J19/12
Inventor 李长平李琢范洪波
Owner DONGGUAN UNIV OF TECH
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