External antipruritic liquid and preparation method thereof

A solution and inhibitor technology, which can be applied to non-active ingredients medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of unsatisfactory antipruritic effect, short effective action time, and single action route. , to achieve the effect of treating bacterial allergic reaction, solving the single way of action, and having a significant effect

Active Publication Date: 2017-11-10
王天啸
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the shortcomings of the existing antipruritic products for external use, such as single action route, slow onset of action, unsatisfactory antipruritic effect, strong skin irritation, easy skin damage

Method used

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  • External antipruritic liquid and preparation method thereof
  • External antipruritic liquid and preparation method thereof
  • External antipruritic liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] An antipruritic solution for external use is made from the following raw materials in parts by weight:

[0071] Mint ice 200, camphor 20, paeonol 30,

[0072] Glycyrrhetinic acid 10, water-soluble azone 36.5, Chinese medicine extract 20.

[0073] The preparation method is as follows:

[0074] First weigh the equal parts of Cnidium Fructus Cnidii, Saponaria thorn, Astragalus, Nepeta, Burnet, Cortex Phellodendri, and Fresh Pitt, mix, rinse with water, dry, crush, add 8 times the amount of water, soak for 2 hours, and decoct After 1 hour, filter the medicinal liquid, and use the filtrate for later use. Under the same conditions, decoct the medicinal residues three times, combine the filtrate, concentrate under reduced pressure to a relative density of 1.36-1.50, and obtain the Chinese medicinal extract;

[0075] Weigh mint ice and camphor, mix and grind to a deep eutectic state, add 5 times the amount of 75% ethanol to dilute and stir to obtain solution 1; take paeonol, ...

Embodiment 2

[0077] An antipruritic solution for external use is made from the following raw materials in parts by weight:

[0078] Mint ice 200, camphor 20, paeonol 30,

[0079] Glycyrrhetinic acid 10, water-soluble azone 26.5, traditional Chinese medicine extract 20,

[0080] Concentration is the natural musk ethanol solution 10 of 1g / L.

[0081] The preparation method is as follows:

[0082] First weigh the equal parts of Cnidium Fructus Cnidii, Saponaria thorn, Astragalus, Nepeta, Burnet, Cortex Phellodendri, and Cortex Alba, mix, rinse with water, dry, crush, add 10 times the amount of water, soak for 2 hours, and decoct After 2 hours, filter the medicinal liquid, and use the filtrate for later use. Repeat decocting the medicinal residue once under the same conditions, combine the filtrate, concentrate under reduced pressure to a relative density of 1.36-1.50, and obtain the Chinese medicinal extract;

[0083] Weigh mint ice and camphor, mix and grind to a deep eutectic state, add ...

Embodiment 3

[0085] An antipruritic solution for external use is made from the following raw materials in parts by weight:

[0086] Mint ice 200, camphor 24, borneol 16,

[0087] Paeonol 30, Glycyrrhizic Acid 5, Glycyrrhetinic Acid 10,

[0088] Baicalin 5, water-soluble azone 28, traditional Chinese medicine extract 25,

[0089] Concentration is the natural musk ethanol solution 10 of 1g / L.

[0090] The preparation method is as follows:

[0091] First weigh the equal parts of Cnidium Fructus Cnidii, Saponaria thorn, Astragalus, Nepeta, Burnet, Cortex Phellodendri, and Fresh Pitt, mix, rinse with water, dry, crush, add 8 times the amount of water, soak for 2 hours, and decoct After 2 hours, the medicinal liquid was filtered, and the filtrate was set aside. Under the same conditions, the medicinal dregs were repeatedly decocted twice, and the filtrate was combined, concentrated under reduced pressure to a relative density of 1.36-1.50, and the Chinese medicinal extract was obtained;

[0...

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Abstract

The invention relates to the field of skin care products and drugs, and in particular relates to an external antipruritic liquid and a preparation method thereof. The external antipruritic liquid is prepared from a skin irritant, an allergic reaction inhibitor, a skin permeation agent and Chinese medical extract. Pharmacological experiments show that the external antipruritic liquid has the ideal alleviating and treatment effect on skin pruritus, and the external antipruritic liquid has advantages of quick effect, wide application range and use safety.

Description

technical field [0001] The invention relates to the fields of skin care products and medicines, in particular to an antipruritic liquid for external use and a preparation method thereof. Background technique [0002] In recent years, with the aggravation of climate change and environmental pollution, the incidence of skin itching symptoms caused by allergies and other reasons has increased rapidly in the population. Drug treatment methods for skin pruritus include: (1) oral drug system therapy, commonly used oral preparations include antihistamines, serotonin receptor antagonists, cetirizine, loratadine, glucocorticoids, etc.; 2) Topical drugs, including lubricants, coolants, local anesthetics, topical antihistamines, topical glucocorticoids, immunosuppressants, etc. [0003] Yet above-mentioned various medicines also have many weak points in the course of treatment. For example, frequent use of chemical drugs such as glucocorticoids will bring about a series of adverse re...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K45/06A61K9/08A61K47/22A61P17/04A61P37/08A61P31/04A61P17/18A61P39/06A61K31/045A61K31/12A61K31/125A61K31/56A61K31/704A61K31/7048A61K35/55
CPCA61K9/0014A61K9/08A61K31/045A61K31/12A61K31/125A61K31/56A61K31/704A61K31/7048A61K35/55A61K36/234A61K36/481A61K36/483A61K36/538A61K36/66A61K36/739A61K36/75A61K36/756A61K45/06A61K47/22A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 王天啸
Owner 王天啸
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