Indolocarbazole compounds as well as preparation method and application of indolocarbazole

A technology of indolecarbazoles and compounds, which is applied in the field of marine actinomycete culture and preparation of compounds, can solve the problems of non-natural sources, etc., and achieve the effects of simple experimental operation, good application prospects, and easy expansion of production
CN107417751AActive Publication Date: 2017-12-01浙江美新控股有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
浙江美新控股有限公司
Publication Date
2017-12-01

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Abstract

The invention discloses an indolocarbazole compounds as well as a preparation method and application of indolocarbazole. The compound is of a structure shown in a formula I, a formula II and formula III as shown in the description. The compound provided by the invention can be used for treating acute leukemia, chronic leukemia, lymphoma, breast cancer, lung cancer, stomach cancer and other cancers related to inhibition of protein kinase, and can be applied to a drug for treating diseases such as Aids, coronary heart disease, diabetes mellitus and senile dementia. The invention also discloses a preparation method of a compound for resisting tumors, the compound for resisting tumors is prepared by fermenting with a marine-derived actinomycetes rice solid culture medium, and separating and purifying a yeast obtained after extraction of ethyl acetate by adopting gel column chromatography and high performance liquid chromatography, and the operation is easy to operate and implement.
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Description

technical field

[0001] The invention relates to the technical field of marine actinomycete culture and preparation of compounds, in particular to three indolecarbazole compounds, their preparation methods and their application in the preparation of drugs with antitumor activity. Background technique

[0002] Indolecarbazoles are a class of alkaloids derived from microbial fermentation broths. The first isolated natural indolecarbazoles were alkaloids isolated from the culture broth of Streptomyces AM-2282 in 1986. Staurosporine (STA), the study found that the compound has antibacterial, antihypertensive, antitumor and strong protein kinase (PKC) inhibitory activity (IC 50 = 2.7 nM). Protein kinase C is a group of phospholipid-dependent Ca 2+ Activated protein serine M / threonine kinase is an important component of cell growth factor signaling and plays an important role in tumor growth. Therefore, targeting protein kinase-associated cancers may serve as an effective target...

Claims

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