Submucosal injection solution

A mucous membrane and solution technology, applied in medical science, surgery, drug delivery, etc., can solve the problems of difficult to reliably remove the target site, affecting the smooth progress of surgery, and low degree of bulge, so as to reduce the inflammatory response and the infiltration of inflammatory cells. , Reduce and inhibit bleeding and oozing, and maintain a long-term effect

Inactive Publication Date: 2017-12-12
SHANDONG WEIGAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is worth noting that when the electric cutting and coagulation mode is used to strip the submucosal tissue during the ESD process, the smoke generated by the ionization of glycerol and fructose seriously interferes with the endoscopic field and affects the smooth progress of the operation.
[0007] Patent application number: 201280052159.7 discloses a submucosal swelling agent, by using xanthan gum, carrageenan, gellan gum

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0033] Example 1

[0034] 0.2 parts by weight of sodium hyaluronate, 0.002 parts by weight of indigo carmine, and 90 parts by weight of water are uniformly mixed to obtain a submucosal injection solution. The viscosity was 13Pa·s, and the uplift was maintained for 32min in the mouse experiment.

Example Embodiment

[0035] Example 2

[0036] 0.5 parts by weight of sodium hyaluronate, 0.005 parts by weight of indigo carmine, 0.001 parts by weight of epinephrine, and 91 parts by weight of water are mixed uniformly to obtain a submucosal injection solution. The viscosity was 28Pa·s, and the bulge was maintained for 46min in the mouse experiment. Example 3

Example Embodiment

[0018] The molecular weight of the sodium hyaluronate is 400 to 3 million Da.

[0037] 1.0 parts by weight of sodium hyaluronate, 0.01 parts by weight of toluidine blue, 0.005 parts by weight of epinephrine and 99 parts by weight of water are mixed uniformly to obtain a submucosal injection solution. The viscosity was 54 Pa·s, and the uplift maintained for 47 minutes in the mouse experiment. Example 4

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Abstract

The invention provides a submucosal injection solution. The submucosal injection solution comprises, by weight, 0.1-3.0 parts of sodium hyaluronate, 0.001-0.02 parts of coloring agent and 90-99 parts of water. The dyeing agent is one or more of indigo carmine, toluidine blue, phenol red, Congo red and crystal violet. The submucosal injection solution has good fluidity and a long swelling effect, and the sodium hyaluronate can serve as a mechanical barrier. The lubricating effect is good, and friction caused by foreign matters in the esophagus, stomach and intestinal tract during wound healing can be reduced. Local inflammatory response and infiltration of inflammatory cells can be reduced, and bleeding and errhysis can be reduced and inhibited. A protective film is formed on the serosa and retained for a long time, so that the serosa covering the surface of an organ can be better repaired. By affecting the viability of immune cells and cytokines, the immune regulatory function is realized, and the submucosal injection solution has angiogenesis and wound healing promoting, anti-tumor, immune regulation and other physiological functions.

Description

technical field [0001] The invention relates to a submucosal injection solution. Background technique [0002] Endoscopic submucosal dissection (Endoscopic submucosal dissection, ESD) is developed by Japanese scholars in the 1990s on the basis of endoscopic mucosal resection (EMR), which integrates the diagnosis and treatment of early gastric cancer. Endoscopic techniques. Studies have shown that compared with traditional laparotomy, endoscopic treatment has a high one-time tumor resection rate, and can effectively avoid complications such as incision infection, incision dehiscence, and dumping syndrome. It has significant advantages in alleviating the suffering of patients during treatment and improving the quality of life of patients, which fully embodies the advantages of minimally invasive. At the same time, ESD can also obtain complete pathological specimens, which is of great significance for diagnosing the development stage of tumors and preventing recurrence. [0...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/14A61L31/04
CPCA61L31/16A61L31/042A61L31/14A61L2300/236A61L2300/426A61L2400/06C08L5/08
Inventor 林栋青王江尹翠竹杜武华黄显峰
Owner SHANDONG WEIGAO PHARM CO LTD
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