A kind of application of black phosphorus nanosheet

Abstract

The invention discloses a black phosphorus nanometer material for treating Alzheimer's disease. Black phosphorus nanosheets are obtained from black phosphorus powder through an ultrasonic liquid stripping method. In addition, the invention also discloses the preparation method and application of the nanometer material. In the present invention, the black phosphorus nanosheets used for the treatment of Alzheimer's disease can effectively and selectively capture Cu 2+ , thereby reducing the formation of reactive oxygen species in cells, as well as protecting cells from Cu 2+ Non-homeostasis related toxicity. The black phosphorus nanosheets provided by the present invention can improve the permeability of the blood-brain barrier through the photothermal effect, overcome the shortcomings of small molecular compounds or polypeptides that cannot penetrate the blood-brain barrier and are unstable, and improve the blood-brain barrier. efficacy. The preparation method of the nanometer material is simple, without additional drug load; high stability and good biocompatibility, so that it has excellent biological safety for the treatment of Alzheimer's disease.

Description

technical field [0001] The invention belongs to the field of preparation of medical materials; in particular, it relates to the application of black phosphorus nanosheets in the preparation of nanomedicine for treating Alzheimer's disease. Background technique [0002] Black phosphorus, as a new type of layered material, is called phosphorene because of its crystal structure similar to graphene, and has received extensive attention in the past few years. It is a honeycomb wrinkled structure, and the van der Waals force between layers is relatively weak, and single-layer nanosheets can be obtained by ultrasonic stripping. Unlike graphene, the energy bandgap of black phosphorus nanosheets (BP) is related to its thickness. The energy bandgap of bulk BP is about 0.3eV, while that of single-layer BP nanosheets is 2.0eV. In addition, because BP nanosheets have high electron mobility, planar anisotropy, and can absorb wavelengths from ultraviolet to the entire visible range, they ...

AI Technical Summary

Problems solved by technology

However, the neuroprotective molecules that have been developed that integrate metal chelating and antioxidant properties cannot cross the blood-brain barrier (BBB); while liposomes, nanovesicles, polymer nano However, due to the laborious drug loading and cumbersome preparation process, their clinical application is limited.

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