Biomarkers for predicting degree of weight loss in male subjects

A biomarker, weight loss technology, used in biological testing, biomaterial analysis, applications, etc.

Inactive Publication Date: 2018-01-02
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, it is well known that male and female individuals have different mechanisms of fat storage and metabolism (Power and Schulkin,. Br J Nutr. 2008; 99:931-40); Mittendorfer et al., Obesity (Silver Spring). 2009; 17: 1872-7; Menegoni et al., Obesity (Silver Spring). 2009;17:1951-6, but few of these physiological sex-specific differences exist in weight loss studies

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  • Biomarkers for predicting degree of weight loss in male subjects
  • Biomarkers for predicting degree of weight loss in male subjects
  • Biomarkers for predicting degree of weight loss in male subjects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] Example 1 - Prediction of weight loss in men following LCD using a combination of plasma biomarkers and anthropometric measurements

[0156] Subjects participated in the Diogenes study. This study is a pan-European, randomized and controlled dietary intervention study investigating the effect of dietary protein and glycemic index on weight loss and weight maintenance in obese and overweight households in eight European centers (Larsen et al., Obesity reviews (2009) , 11, 76-91).

[0157] Weight loss trajectories were investigated in a cohort of overweight / obese individuals participating in an eight-week LCD weight loss program (Larsen et al., 2010).

[0158] The study included 938 European individuals, of whom 782 completed the 8-week LCD program and 714 completed all required measurements in the range acceptable for live subjects. The general characteristics of the individuals are shown in Table 1.

[0159]

[0160] Table 1: General Characteristics of Individ...

Embodiment 2

[0170] Example 2: Stratifying Men According to Predicted Weight Loss and Success Thresholds

[0171] The term "weight loss tolerance" is understood as the predicted percent weight loss below a predetermined threshold. For example, "tolerance to weight loss" can be defined as predicted loss in bmi units less than the 30th or 15th percentile of expected bmi reduction (where bmi reduction = (bmi1-bmi2)*100% / bmi1).

[0172] The term "weight loss sensitive" is understood as a predicted percent weight loss above a predetermined threshold. For example, "weight loss sensitive" can be defined as a predicted decrease in bmi units greater than the 70th percentile or 85th percentile of the expected bmi decrease.

[0173] The expected mean median or other percentile of bmi reduction can be obtained by the skilled artisan on a sample of subjects (from the population of interest) who have been subjected to a dietary intervention similar to the one to be used.

[0174] Receiver operatin...

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Abstract

A method for predicting the degree of weight loss in male subject attainable by applying one or more dietary interventions to a subject, said method comprising determining the level of one or more biomarkers in one or more samples obtained from the subject, wherein the biomarkers are selected from sex hormone-binding globulin, beta-2-microglobulin and serum paraoxonase / arylesterase.

Description

technical field [0001] The present invention provides a plurality of biomarkers and biomarker combinations that can be used to determine a sex-specific weight loss trajectory in an individual, and also provides methods for optimizing dietary interventions. Background technique [0002] Obesity is a chronic metabolic disorder that has reached epidemic proportions in many parts of the world. Obesity is a major risk factor for serious comorbidities such as type 2 diabetes, cardiovascular disease, dyslipidemia and certain types of cancer (World Health Organ Tech Rep Ser. 2000; 894:i-xii, 1-253). [0003] It has long been recognized that hypocaloric dietary interventions are very effective in reducing body weight and that this weight loss is often accompanied by an improvement in the risk of obesity-related comorbidities, especially type 2 diabetes (World Health Organ TechRep Ser. 2000; 894: i- xii, 1-253). Empirical data indicate that a weight loss of at least 10% of initial b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N2333/70539G01N2333/723G01N2333/918G01N2800/04G01N2800/044G16H50/30G16H20/60G01N33/6893G16H10/40G16H50/20A61B5/00G01N2800/52
Inventor I·伊林奇瓦J·哈格尔L·达永O·科米内蒂
Owner SOC DES PROD NESTLE SA
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