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Biomacromolecule NHERF1 related to cisplatin resistance of cervical cancers, and applications thereof

A biomacromolecule and cervical cancer technology, applied in the fields of application, biological testing, biochemical equipment and methods, etc., can solve problems such as the effect of tumor treatment and secondary drug resistance of tumor cells

Active Publication Date: 2018-01-05
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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Problems solved by technology

However, while affirming the efficacy of cisplatin, secondary drug resistance of tumor cells also appears, which has a significant impact on the therapeutic effect of tumors.

Method used

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  • Biomacromolecule NHERF1 related to cisplatin resistance of cervical cancers, and applications thereof
  • Biomacromolecule NHERF1 related to cisplatin resistance of cervical cancers, and applications thereof
  • Biomacromolecule NHERF1 related to cisplatin resistance of cervical cancers, and applications thereof

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Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with specific embodiments, and what is called is an explanation of the present invention rather than a limitation.

[0015] Cisplatin plays an important role in the treatment of cervical cancer, but the emergence of drug resistance is the main reason for limiting its clinical efficacy. To clarify the biological function and mechanism of PDZ protein NHERF1 in cisplatin resistance of cervical cancer cells will provide new biological target selection for effectively improving the clinical efficacy of cervical cancer.

[0016] The present invention discloses that the expression of NHERF1 decreases in cisplatin-resistant cervical cancer cells, and at the same time, it is low-expressed in patients receiving cisplatin chemotherapy for cervical cancer and has the characteristic of decreasing expression as the concentration of chemotherapy drugs increases. It is a new A marker of cisplatin resistance ...

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Abstract

The invention discloses a PDZ protein molecule NHERF1 related to cisplatin resistance, and applications thereof, and belongs to the field of biological treatment of tumors. The invention further discloses a PDZ protein molecule NHERF1 related to cisplatin resistance, wherein the PDZ protein molecule NHERF1 is lowly expressed in cisplatin-resistant cervical cancer cell lines and is the new cisplatin-resistant cervical cancer marker, such that the new target is provided for the design of drugs resisting the cisplatin resistance of cervical cancers, and the new drug directly for the cisplatin resistance of cervical cancers can be designed and developed based on the new target; and the PDZ protein molecule NHERF1 has the biological function and mechanism of the promotion of the drug resistanceof cervical cancer cells so as to provide the effective approach for the effective reversing of the cisplatin resistance of cervical cancers and the improving of the clinical chemotherapy effects ofcervical cancers.

Description

technical field [0001] The invention belongs to the field of tumor biological treatment, and in particular relates to a PDZ protein molecule NHERF1 related to cisplatin resistance and its application. Background technique [0002] Cervical cancer is one of the most common malignant tumors in women, and its incidence seriously threatens women's physical and mental health. At present, the incidence of malignant tumors of cervical cancer in my country is higher than the mortality rate in foreign countries, ranking fourth in the mortality rate of all malignant tumors. [0003] The early treatment of cervical cancer is still based on surgery, supplemented by comprehensive chemotherapy. Before surgery, there is a combined chemotherapy regimen based on platinum and supplemented by other chemotherapy drugs, which significantly improves the killing efficiency of cancer cells. Cisplatin is widely used in the clinical treatment of various types of solid tumors. The combination of th...

Claims

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Application Information

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IPC IPC(8): C07K14/47C12N15/12G01N33/68C12Q1/6886
Inventor 贺俊崎杨晓梅陶涛施文
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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