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Liquid paraffin micro-capsule and preparing method thereof

A technology of liquid paraffin and deionized water, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of high cost, lower yield, foam generation, etc., achieve specific shape, shorten reaction time, and accelerate coagulation and curing Effect

Inactive Publication Date: 2018-02-02
安徽金阳光农业服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The coagulation effect of the single coacervation method is uncontrollable, and satisfactory microcapsules need to be made after many repetitions, which has low efficiency and high cost; the complex coacervation method has higher requirements for operation, and the solution must be stirred evenly when adjusting the pH value. And to reach a specific pH range, always stir during the preparation of microcapsules, and stirring will produce foam and reduce the yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: liquid paraffin microcapsules, it comprises by weight: 10 parts of liquid paraffin, 6 parts of rosin, 8 parts of compressible starch, 4 parts of gum arabic, 6 parts of solid aluminum sulfate and 20 parts of deionized water.

[0012] A method for preparing liquid paraffin microcapsules, comprising the following steps: putting 8 parts of compressible starch in 20-30 parts of deionized water, stirring evenly, heating to 40°C, concentrating and distilling to make a soft capsule of 1 / 4 of the original volume. Grind 6 parts of rosin into fine powder and pass through a 100-mesh sieve, then add it to the soft material and stir evenly at 20°C for 20 minutes; add 10 parts of liquid paraffin and put it into the reactor and stir evenly at a stirring speed of 50r / min; add Heat 4 parts of gum arabic to 60°C and keep it warm for 10 minutes; add 6 parts of solid aluminum sulfate and cool to 10°C within 3 minutes.

Embodiment 2

[0013] Embodiment 2: liquid paraffin microcapsules, it comprises by weight: 15 parts of liquid paraffin, 8 parts of rosin, 9 parts of compressible starch, 6 parts of gum arabic, 8 parts of solid aluminum sulfate and 25 parts of deionized water.

[0014] The preparation method of liquid paraffin microcapsules comprises the following steps: placing 9 parts of compressible starch in 25 parts of deionized water, stirring evenly, heating to 45°C, concentrating and distilling to make a soft material of 1 / 5 of the original volume, Grind 8 parts of rosin into fine powder and pass through a 100-mesh sieve, then add it to soft material and stir evenly, keep it warm at 25°C for 25 minutes; add 15 parts of liquid paraffin, put it into the reaction kettle and stir evenly, the stirring speed is 55r / min; add 6 parts Gum Arabic was heated to 65°C and kept for 15 minutes; after adding 8 parts of solid aluminum sulfate, it was cooled to 12°C within 5 minutes.

Embodiment 3

[0015] Embodiment 3: Liquid paraffin microcapsules, which include by weight: 20 parts of liquid paraffin, 12 parts of rosin, 10 parts of compressible starch, 8 parts of gum arabic, 10 parts of solid aluminum sulfate and 30 parts of deionized water.

[0016] The preparation method of liquid paraffin microcapsules comprises the following steps: putting 10 parts of compressible starch in 30 parts of deionized water, stirring evenly, heating to 50°C, concentrating and distilling to make a soft material of 1 / 6 of the original volume, Grind 12 parts of rosin into fine powder, pass through a 100-mesh sieve, add to soft material and stir evenly, keep warm at 30°C for 30 minutes; add 20 parts of liquid paraffin, put it into the reactor and stir evenly, the stirring speed is 60r / min; Gum Arabic was heated to 70°C and kept for 20 minutes; after adding 10 parts of solid aluminum sulfate, it was cooled to 14°C within 7 minutes.

[0017] The present invention utilizes the high drug holding ...

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Abstract

The invention discloses a liquid paraffin micro-capsule. The liquid paraffin micro-capsule is prepared from, by weight, 10-20 parts of liquid paraffin, 6-12 parts of rosin, 8-10 parts of compressiblestarch, 4-8 parts of Arabic gum, 6-10 parts of solid aluminum sulfate and 20-30 parts of deionized water. The liquid paraffin micro-capsule has the advantages that the added compressible starch can promote preforming of capsule materials, the prepared liquid paraffin micro-capsule has a certain shape and does not need to be repeatedly condensed, the rosin and solid aluminum sulfate can acceleratecondensing and curing of the micro-capsule, the reaction time is shortened, and the stable micro-capsule is formed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to liquid paraffin microcapsules and a preparation method thereof. Background technique [0002] Microcapsules (referred to as microcapsules) use polymer materials (commonly known as capsule materials) to wrap solid or liquid drugs (commonly known as capsule cores) into microcapsules with a diameter of 0.01-200 μm. After the drug is microencapsulated, it has a slow-release effect, which can improve the stability of the drug, mask the bad smell and taste of the drug, reduce the irritation of the drug to the gastrointestinal tract, reduce the incompatibility of compound drugs, and improve the fluidity and availability of the drug. Compressibility, so that liquid drugs can be solidified. There are many preparation methods of microcapsules, which can be classified into three categories: physical chemical method, chemical method and physical mechanical method. It can be selec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/06A61K47/36A61K47/02A61K47/46
CPCA61K9/5015A61K9/501A61K9/5036A61K9/5063
Inventor 陆必红
Owner 安徽金阳光农业服务有限公司
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