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Norfloxacin-containing medicinal composition and preparation method thereof

The technology of norfloxacin and composition is applied in the field of pharmaceutical compositions containing norfloxacin and the preparation thereof, which can solve the problems such as difficulty in meeting the medication needs of patients, and achieve the improvement of gastrointestinal reactions, good antibacterial effect and curative effect. Good results

Inactive Publication Date: 2018-02-02
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regardless of the method, various side effects are prone to occur, such as abdominal pain, diarrhea, nausea, headache, insomnia, etc., and it is difficult to meet the medication needs of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] This embodiment also provides a preparation method of the above-mentioned pharmaceutical composition, which includes:

[0030] Step S1: Mix malt, divine music, sealwort, astragalus, poria cocos, wolfberry, Polygonum multiflorum and Bupleuri in parts by weight, obtain a medicinal solution by solvent extraction, and concentrate to obtain an ointment.

[0031] Further, the solvent extraction method includes decoction method, heating reflux extraction method, ultrasonic extraction method, and percolation method. Preferably, it is extracted by heating and refluxing extraction. The extraction solvent is a water-water-soluble organic solvent mixed system. Further, a water-alcohol mixed system can be used, which can be a water-ethanol solution. Preferably, an ethanol solution with a volume fraction of 70-80% is used.

[0032] Further, the relative density measured at 54-56°C of the ointment is 1.17-1.22, or the relative density measured at 55°C of the ointment is 1.19-1.21; or...

Embodiment 1

[0038] The present embodiment provides a kind of pharmaceutical composition comprising norfloxacin, and its raw material comprises:

[0039] Norfloxacin 30g, Malt 50g, Divine Comedy 80g, Polygonatum 100g, Astragalus 50g, Poria 90g, Lycium barbarum 100g, Polygonum multiflorum 20g and Bupleurum 40g.

[0040] The preparation method of this pharmaceutical composition comprises:

[0041] a. Mix malt, Divine Comedy, Polygonatum, Radix Astragali, Poria, Lycium barbarum, Polygonum multiflorum and Bupleurum, extract by heating and reflux extraction, the extraction solvent is 80% ethanol, extract twice, each time for 1.5h, extract twice The obtained medicinal liquid is filtered and concentrated to obtain ointment;

[0042] b. The norfloxacin of 30g is mixed with ointment, adds pharmaceutical auxiliary material and carries out preparation.

Embodiment 2

[0044] The present embodiment provides a kind of pharmaceutical composition comprising norfloxacin, and its raw material comprises:

[0045] Norfloxacin 60g, Malt 80g, Divine Comedy 40g, Polygonatum 90g, Astragalus 70g, Poria 60g, Lycium barbarum 60g, Polygonum multiflorum 20g and Bupleurum 50g.

[0046] The preparation method of this pharmaceutical composition comprises:

[0047] a. Mix malt, Divine Comedy, Polygonatum, Radix Astragali, Poria, Lycium barbarum, Polygonum multiflorum and Bupleurum, extract by heating and reflux extraction, the extraction solvent is 70% ethanol, extract twice, each time for 1h, and extract twice to obtain The liquid medicine is filtered and concentrated to obtain ointment;

[0048] b. The norfloxacin of 60g is mixed with ointment, adds pharmaceutical auxiliary material and carries out preparation.

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PUM

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Abstract

The invention provides a norfloxacin-containing medicinal composition and a preparation method thereof, and belongs to the field of medicines. Raw materials of the medicinal composition include norfloxacin, malt, medicated leaven, Polygonatum sibiricum, Radix Astragali, Poria cocos, wolfberry fruits, Polygonum multiflorum and radix bupleuri. The preparation method comprises the following steps: mixing the malt, medicated leaven, Polygonatum sibiricum, Radix Astragali, Poria cocos, wolfberry fruits, Polygonum multiflorum and radix bupleuri, performing a solvent extraction technology to obtain amedicinal solution, and concentrating the medicinal solution to obtain a medicinal paste; and mixing the norfloxacin with the medicinal paste to obtain the medicinal composition. The medicinal composition adopting norfloxacin as a main antibacterial substance has a broad-spectrum antibacterial effect. Traditional Chinese medicinal materials having the efficacy of invigorating the spleen, nourishing the stomach, protecting the liver and tonifying the kidney are adopted as auxiliary materials to effectively improve the gastrointestinal reactions and liver and kidney injuries of patients takingthe norfloxacin. Various medicines are combined to cooperatively resist the medicine resistance of bacteria, and the medicinal composition has broad spectrum antibacterial effect, good antibacterial effect, healthy energy supporting and body resistance consolidating effects, small side effects and good curative effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition containing norfloxacin and a preparation method thereof. Background technique [0002] Norfloxacin, a third-generation quinolone antibacterial drug, has a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli. Norfloxacin can hinder the action of DNA gyrase of pathogenic bacteria in the digestive tract, hinder bacterial DNA replication, and have an inhibitory effect on bacteria. Norfloxacin has a good antibacterial effect on the following bacteria in vitro: most bacteria of Enterobacteriaceae, including Citrobacter, Enterobacter cloacae, Enterobacter aerogenes and other Enterobacter species, Escherichia coli, Klebsiella Bacteria, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. [0003] In the process of drug use, bacteria are prone to drug resistance, which reduces their sensitivity to drugs, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61P31/04A61K31/496
CPCA61K31/496A61K36/00A61K36/076A61K36/233A61K36/481A61K36/704A61K36/815A61K36/8969A61K36/8998A61K2300/00
Inventor 方同华许照芹项彦华贾文娟
Owner HEILONGJIANG ZBD PHARMA
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