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A preparation method of high-stability microcapsules containing more double-bond fat-soluble nutrients

A fat-soluble nutrient and high stability technology, applied in the direction of microcapsules, nanocapsules, medical preparations containing active ingredients, etc., can solve the problem of excessive organic solvent residues, reduced coating performance, and prolonged removal of organic solvents Time and other issues

Active Publication Date: 2021-08-31
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dissolving nutrients in an organic solvent and then emulsifying and dispersing them into a stable matrix, then removing the organic solvent and then granulating them is a good method for preparing microcapsules, but there are several points in the preparation of microcapsules by the conventional organic solvent method Defects, the first is the damage of organic solvents to the embedding wall material, especially gelatin, many organic solvents will denature the wall material, thereby reducing its coating performance
Secondly, since most of the coated wall materials themselves have emulsifying properties, the existence of these coated wall materials will make it difficult to remove the organic solvent, which will lead to more organic solvent residues in the final product, which will affect the safety of the product. brings certain risks
Finally, due to the existence of the coating wall material, the viscosity of the emulsion becomes larger, which makes the removal of the organic solvent more difficult, prolongs the time used for the removal of the organic solvent, and is detrimental to the stability of the product

Method used

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  • A preparation method of high-stability microcapsules containing more double-bond fat-soluble nutrients
  • A preparation method of high-stability microcapsules containing more double-bond fat-soluble nutrients
  • A preparation method of high-stability microcapsules containing more double-bond fat-soluble nutrients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Weigh 60.7g of lutein (content 82.4%), add 2.0g of mixed tocopherols, and dissolve with 1600 ml of tetrahydrofuran at 60°C to obtain an oil phase.

[0068] Take 8.0 g of ascorbyl palmitate in 400 ml of water, heat up to 40° C. and stir to dissolve to obtain an aqueous phase. Add the water phase into the shear kettle, turn on the shear and stir, and slowly add the oil phase at the same time, so that the oil phase and the water phase are fully sheared, mixed and emulsified. After the emulsification is completed, the emulsion temperature is 45°C and the viscosity is 68cPa. It is homogenized by a high-pressure homogenizer with a homogenization pressure of 30MPa. After the homogenization is completed, the emulsion temperature is 52°C. Tetrahydrofuran was recovered under reduced pressure to obtain an emulsion dispersed with lutein nano-sized droplets.

[0069] Under the condition of shearing and stirring, add 450 g of gelatin aqueous solution (including 160.0 g of gelatin an...

Embodiment 3

[0082] Fish oil omega-3 fatty acid ethyl ester (EPA 34.2%, DHA 22.6%, total omega-3 fatty acid 59.4%) 45g, add 3.0g synthetic tocopherol, acetone 100mL, stir evenly at 30°C to obtain an oil phase. Take 15g of sorbitol palmitate, add 750ml of water and dissolve at 40°C to prepare an aqueous phase, and simultaneously add 3.5g of sodium ascorbate to the aqueous phase. Slowly add the oil phase into the water phase under shear, and shear and mix for 10 minutes to obtain a mixed emulsion with a viscosity of 120 cPa. The obtained emulsion is homogenized by a homogenizer, the homogenization pressure is 20Mpa, and the homogenization is easy to carry out. During the homogenization process, the temperature of the emulsion is raised by 5°C, and the acetone solvent is recovered under normal pressure. The average droplet size in the obtained emulsion is 234nm.

[0083] Under the condition of shearing, add 150g sodium starch octyl succinate (modified starch) to the emulsion after recovering ...

Embodiment 4-10

[0086] Table 2 lists the implementation objects and related parameters of Examples 4-10.

[0087]

[0088]

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Abstract

The invention provides a method for preparing high-stability microcapsules containing more double-bond fat-soluble nutrients. The oil phase formed by the solvent is emulsified and mixed, and the nano-scale oil-in-water emulsion is obtained by high-pressure homogenization. After removing the organic solvent in the emulsion, the coating wall material is directly added to the emulsion, and sheared under mild conditions. Cut and mix evenly, and obtain microcapsule dry powder or particles after granulation and drying. The microcapsule dry powder and particles obtained by the preparation method of the invention have good stability and no bad smell, and are suitable for application in food and dietary supplements.

Description

technical field [0001] The invention relates to a method for preparing fat-soluble nutrient highly stable microcapsule dry powder / particles. More specifically, the present invention creatively dissolves the nutrients in an organic solvent first, and mixes them with the water phase that only dissolves a small amount of emulsification stabilizer through high-shear emulsification to obtain a nano-dispersed emulsion and immediately remove the organic solvent. Then add the nano-scale particles stably formed by the embedding wall material, and obtain highly stable microcapsule dry powder or particles after granulation and drying. During this process, the damaging effect of the organic solvent on the embedding wall material is avoided, and the stability of the product is enhanced. Background technique [0002] With the focus on health, more and more people are more and more willing to maintain their health through daily intake of some vitamins and healthy dietary ingredients. Amon...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K9/51A61K9/14A61K31/047A61K31/202A61K47/26A61K47/22A61P39/06A61P35/00A61P25/28A61P25/16A61P17/00A61P9/00A61P27/12
CPCA61K9/145A61K9/5036A61K9/5052A61K9/5057A61K9/5123A61K31/047A61K31/202
Inventor 许新德张莉华邵斌周迪
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY