A stable soluble methotrexate granule
A methotrexate and soluble technology, applied in the direction of non-central analgesics, anti-inflammatory agents, organic active ingredients, etc., can solve the problems of inaccurate dosage division of active ingredients, low oral bioavailability, difficult storage and transportation, etc. , to achieve the effect of solving inaccurate dose division, good stability and high bioavailability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0038] Embodiment 1: Preparation of soluble methotrexate granules
[0039] 1. Raw material prescription:
[0040] Methotrexate 120 grams, disodium hydrogen phosphate 68.64 grams, citric acid 75.24 grams, sodium hydroxide 60 grams, hydroxypropyl cellulose 48 grams, mannitol 150 grams, sucralose 60 grams, flavoring agent 6 grams.
[0041] 2. Preparation process:
[0042] (1) adding water to the hydroxypropyl cellulose of prescription quantity is mixed with the aqueous solution of 4wt%, for subsequent use;
[0043] (2) Weigh the methotrexate, disodium hydrogen phosphate, citric acid, sodium hydroxide, sucralose and flavoring agent in the prescribed amount, add them to the aqueous solution of step (1), and stir until fully dissolved;
[0044] (3) Preheat the prescribed amount of mannitol in a fluidized bed for 5 minutes, add the top spray into the solution in step (2) and stir until it is completely dissolved, the air temperature at the spray inlet is 70°C, the atomization press...
Embodiment 2
[0045] Embodiment 2: Preparation of soluble methotrexate granules
[0046] 1. Raw material prescription:
[0047] Methotrexate 100g, disodium hydrogen phosphate 80g, citric acid 70g, sodium hydroxide 100g, hydroxypropyl cellulose 30g, mannitol 160g, sucralose 40g, flavoring agent 10g.
[0048] The preparation process is the same as in Example 1.
Embodiment 3
[0049] Embodiment 3: Preparation of soluble methotrexate granules
[0050] 1. Raw material prescription:
[0051] Methotrexate 140 grams, disodium hydrogen phosphate 60 grams, citric acid 80 grams, sodium hydroxide 8.5 grams, hydroxypropyl cellulose 60 grams, mannitol 140 grams, sucralose 80 grams, flavoring agent 5 grams.
[0052] The preparation process is the same as in Example 1.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com