Malus toringoides flavone-beta-cyclodextrin inclusion compound and preparation method thereof

A technology of cyclodextrin inclusion compound and russian flavonoids, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of poor solubility, etc., achieve stable quality, simple and easy method, and expand the effect of application channels

Inactive Publication Date: 2018-02-27
炉霍雪域俄色有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above existing problems, the first purpose of the present invention is to provide a Russian flavonoid-β-cyclodextrin inclusion compound, which expands the app...

Method used

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  • Malus toringoides flavone-beta-cyclodextrin inclusion compound and preparation method thereof
  • Malus toringoides flavone-beta-cyclodextrin inclusion compound and preparation method thereof

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Experimental program
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Embodiment 1

[0033] This embodiment provides a russet-β-cyclodextrin inclusion compound, the raw material of which includes russet and β-cyclodextrin in a mass ratio of 1:2. Russe flavonoid has anti-"three highs" effect, but its solubility is small, it is prepared into -β-cyclodextrin inclusion complex, and russaflavone enters the internal hydrophobic space of -β-cyclodextrin as a guest molecule The cavity increases its solubility and also has a sustained release effect.

Embodiment 2

[0035] The present embodiment provides a kind of extraction method of russet flavone, it comprises the steps:

[0036] Step 1: Take the Russian medicinal material, add 55% ethanol solution according to the mass-to-liquid ratio of 1:3, ultrasonically extract at 50°C for 2 hours, and filter to obtain a crude solution.

[0037] Step 2: Add hydrochloric acid solution to the crude solution under stirring, adjust the pH to 2, let it stand for 1 hour, and filter under reduced pressure to obtain russetflavone.

Embodiment 3

[0039] The present embodiment provides a kind of extraction method of russet flavone, it comprises the steps:

[0040] Step 1: Take the Russian medicinal material, add 55% ethanol solution according to the mass-to-liquid ratio of 1:5, and conduct ultrasonic extraction for the first time at 70°C for 1 hour. During the extraction process, add transfer glucosidase to the extract until its The concentration in the extract is 0.6mg / mL. After the extraction is completed, filter to obtain the first filtrate. Then carry out secondary extraction under the same conditions, filter to get the second filtrate, combine the first filtrate and the second filtrate to obtain a crude solution.

[0041] Step 2: Add hydrochloric acid solution to the crude solution under stirring, adjust the pH to 3, let it stand for 1 hour, and filter under reduced pressure to obtain russetflavone.

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Abstract

The invention discloses a malus toringoides flavone-beta-cyclodextrin inclusion compound and a preparation method thereof and relates to the field of medicine preparation. The malus toringoides flavone-beta-cyclodextrin inclusion compound comprises malus toringoides flavone and beta-cyclodextrin according to a mass ratio of 1:2. The preparation method comprises the following steps: respectively dissolving malus toringoides flavone and beta-cyclodextrin into absolute ethyl alcohol and deionized water so as to form saturated solutions; under stirring, heating the beta-cyclodextrin saturated solution to 80 DEG C, adding the malus toringoides flavone saturated solution, and performing a reaction for 3 hours continuously; performing freeze-drying, thereby obtaining a crude product. As the malustoringoides flavone is prepared into the beta-cyclodextrin inclusion compound, the application way of malus toringoides is widened, and in addition quality controllability is achieved after the malustoringoides is prepared into a molded preparation. The invention provides a reasonable and feasible preparation method, the preparation method is simple, convenient and feasible, the prepared inclusion compound is soft, fine and uniform powder, malus toringoides flavone which does not enter the beta-cyclodextrin can be easily removed, stable quality is achieved, and testing of medicine propertiesis not affected.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a russin-β-cyclodextrin inclusion compound and a preparation method thereof. Background technique [0002] The "three highs" refer to high blood pressure, high blood sugar (diabetes) and hyperlipidemia. They are the "diseases of wealth" derived from modern society. They may exist alone or may be related to each other. With the improvement of living standards and changes in the rhythm of life, the "three highs" have become like "the old swallows before Wang Xietang, flying into the homes of ordinary people", especially the common diseases of the middle-aged and elderly people over 50 years old, and they have recently become obvious. rejuvenation trend. The number of people who die from cardiovascular and cerebrovascular diseases is as high as 15 million every year in the world, ranking first among various causes of death. Cardiovascular and cerebrovascular diseases hav...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K36/73A61P9/12A61P3/10A61P3/06A61K127/00
CPCA61K36/73A61K2236/333
Inventor 雷敏谢雨蕉李敏毛羽
Owner 炉霍雪域俄色有限责任公司
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