Antiviral antipyretic compound Chinese herbal medicine preparation and preparation method thereof

An antiviral and traditional Chinese medicine technology, applied in antiviral agents, antipyretics, anti-inflammatory agents, etc., can solve the problems of poor absorption, low bioavailability, poor fat solubility and water solubility of baicalin, and promote dissolution , low cost, short cycle effect

Inactive Publication Date: 2018-03-13
SHANGHAI KAIBAO PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Invention patent ZL03801243.X provides an antiviral antipyretic preparation, the main raw materials of which include Folium Folium Folium, Scutellaria baicalensis, honeysuckle, artificial bezoar, green qiao, light bamboo leaves, burdock seed, peppermint, etc., the antiviral antipyretic The granules have curative effect on upper respiratory tract infection and lung infection caused by viral influenza, common cold, etc., but the antiviral and antipyretic granules still have room for improvement
On the one hand, the Scutellaria baicalensis extract is used in this compound preparation. The main component of the Scutellaria baicalensis extract is baicalin, which has many activities such as antibacterial, heat-clearing, and anti-inflammatory. Poor, resulting in poor absorption in the body, low bioavailability, and extremely unstable drug efficacy, thus limiting the clinical application effect of compound preparations
On the other hand, its antiviral efficacy needs to be further improved

Method used

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  • Antiviral antipyretic compound Chinese herbal medicine preparation and preparation method thereof
  • Antiviral antipyretic compound Chinese herbal medicine preparation and preparation method thereof
  • Antiviral antipyretic compound Chinese herbal medicine preparation and preparation method thereof

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Embodiment 1

[0038] Embodiment 1: Chinese medicine compound antiviral antipyretic preparation 1

[0039] (1) Weighing in parts by weight: 20 parts of Daqingye, 160 parts of Scutellaria baicalensis, 160 parts of honeysuckle, 1.2 parts of artificial bezoar, 100 parts of forsythia, 30 parts of light bamboo leaves, 30 parts of arctium, 1 part of peppermint oil, licorice 15 parts of extract, and an appropriate amount of sodium bicarbonate as a pH regulator; pulverize the above-mentioned raw materials of traditional Chinese medicines;

[0040] (2) Mix Forsythia japonicus, Pachyphyllum fructus and Burdock Fructus, extract by heating and refluxing with water, the temperature of heating and refluxing extraction is 80°C, extract 4 times, each time for 60 minutes, filter the extract to obtain the supernatant;

[0041] (3) Flos Lonicerae Flos Lonicerae and Folium Folium Leach are extracted 3 times with 90% ethanol, and the extract is filtered to obtain the filtrate;

[0042] (4) Decoct and extract Sc...

Embodiment 2

[0045] Embodiment 2: Chinese medicine compound antiviral antipyretic preparation 2

[0046] (1) Weighing in parts by weight: 20 parts of Daqingye, 160 parts of Scutellaria baicalensis, 160 parts of honeysuckle, 1.2 parts of artificial bezoar, 100 parts of forsythia, 30 parts of light bamboo leaves, 30 parts of arctium, 1 part of peppermint oil, licorice 15 parts of extract, 15 parts of mountain bean root, and an appropriate amount of sodium citrate as a pH regulator, and pulverize each raw material of traditional Chinese medicine;

[0047] (2) Mix Forsythia japonicus, Pachyphyllum fructus and Burdock Fructus, extract by heating and refluxing with water, the temperature of heating and refluxing extraction is 80°C, extract 4 times, each time for 60 minutes, filter the extract to obtain the supernatant;

[0048] (3) Flos Lonicerae Flos Lonicerae and Folium Folium are extracted 3 times with 70% ethanol, and the extract is filtered to obtain the filtrate;

[0049] (4) Scutellaria ...

Embodiment 3

[0053] Embodiment 3: Chinese medicine compound antiviral antipyretic preparation 3

[0054] (1) Weighing in parts by weight: 20 parts of Daqingye, 160 parts of Scutellaria baicalensis, 160 parts of honeysuckle, 1.2 parts of artificial bezoar, 100 parts of forsythia, 30 parts of light bamboo leaves, 30 parts of arctium, 1 part of peppermint oil, licorice 15 parts of extract, 15 parts of mountain bean root, and an appropriate amount of sodium citrate as a pH regulator, and pulverize each raw material of traditional Chinese medicine;

[0055] (2) Mix Forsythia japonicus, Pachyphyllum fructus and Burdock Fructus, extract by heating and refluxing with water, the temperature of heating and refluxing extraction is 80°C, extract 4 times, each time for 60 minutes, filter the extract to obtain the supernatant;

[0056] (3) Flos Lonicerae Flos Lonicerae and Folium Folium are extracted 3 times with 70% ethanol, and the extract is filtered to obtain the filtrate;

[0057] (4) Scutellaria ...

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Abstract

The invention discloses an antiviral antipyretic compound Chinese herbal medicine preparation and a preparation method thereof. The antiviral antipyretic compound Chinese herbal medicine preparation is prepared from, by weight, 10-30 parts of folium isatidis, 120-200 parts of radix scutellariae, 120-200 parts of flos lonicerae, 1-1.5 parts of calculus bovis artifactus, 60-120 parts of fructus forsythiae, 20-40 parts of herba lophatheri, 20-40 parts of fructus arctii, 0.2-2 parts of oleum menthae, 2-20 parts of extractum glycyrrhizae and the balance being PH modifier. The weight of the PH modifier needs to meet the requirement of regulating the PH value of the compound Chinese herbal preparation to be 7 to 9. By optimization of the radix scutellariae extraction process and use of the PH modifier, the absorption characteristic of radix scutellariae extract is improved, bioavailability of the radix scutellariae extract is increased, and thus, antiviral pharmacodynamics activity of the compound Chinese herbal medicine preparation is improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine antiviral antipyretic preparation and a preparation method thereof. Background technique [0002] Flu is a kind of common disease, is divided into common cold and influenza. Influenza is an acute respiratory infectious disease caused by influenza virus. Viruses that cause influenza include respiratory syncytial virus, rhinovirus, adenovirus, coronavirus, and parainfluenza virus. Usually, influenza has severe symptoms and more complications than colds. Its incidence rate is high and its impact is wide. Cause sinusitis, pharyngitis, bronchitis, pneumonia, asthma and other diseases. [0003] Currently clinically treat colds, Western medicine usually adopts symptomatic methods such as antibacterial and anti-inflammatory, anti-allergic, antipyretic and pain-relieving or antiviral treatment. For example, penicillin, cepha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K47/02A61K47/12A61P31/12A61P11/00A61P31/16A61P29/00A61K35/413
CPCA61K35/413A61K36/195A61K36/28A61K36/315A61K36/355A61K36/484A61K36/489A61K36/534A61K36/539A61K36/634A61K36/704A61K36/855A61K36/899A61K47/02A61K47/12A61K2236/19A61K2236/331A61K2236/333A61K2236/53A61K2236/55A61K2300/00
Inventor 张小利刘绍勇王国明
Owner SHANGHAI KAIBAO PHARMA
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