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A kind of 3D printing aminophylline orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and ammonia printing, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, and medical preparations containing active ingredients, etc. Low toxic and side effects of drugs, personalized printing, and good formability

Active Publication Date: 2021-02-09
江苏互竑生物医学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the disintegration time of ordinary aminophylline tablets in the market is long, which cannot meet the needs of emergency patients; in addition, atomized inhalation of aminophylline solution can take effect quickly, but it needs atomization equipment and cannot be administered anytime and anywhere. Meet patient needs

Method used

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  • A kind of 3D printing aminophylline orally disintegrating tablet and preparation method thereof
  • A kind of 3D printing aminophylline orally disintegrating tablet and preparation method thereof
  • A kind of 3D printing aminophylline orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The prescription is as follows:

[0029]

[0030] 3D printing parameters are as follows:

[0031]

[0032]

[0033] The preparation method is as follows:

[0034] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer.

[0035] (2) Calculated by mass percentage, mix aminophylline, mannitol, povidone K30, and micropowdered silica gel evenly in proportion, and put them into the powder box of the 3D printing rapid prototyping machine as medicinal powder.

[0036] (3) Put 1% povidone K30-50% ethanol solution into the ink cartridge.

[0037] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print aminophylline orally disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.1mm on the powder bed, and then prints the nozzle in the direction...

Embodiment 2

[0042] The prescription is as follows:

[0043]

[0044] 3D printing parameters are as follows:

[0045]

[0046] The preparation method is as follows:

[0047] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer.

[0048] (2) Calculated by mass percentage, mix aminophylline, pregelatinized starch, cross-linked polyvinylpyrrolidone, povidone K30, micropowder silica gel, and aspartame in proportion, and load it into a 3D printing rapid prototyping machine as a medicine powder in the powder box.

[0049] (3) Put 1% povidone K30-50% ethanol solution into the ink cartridge.

[0050](4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print aminophylline orally disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.2mm on the powder bed, and the...

Embodiment 3

[0055] The prescription is as follows:

[0056]

[0057]

[0058] 3D printing parameters are as follows:

[0059]

[0060] The preparation method is as follows:

[0061] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer.

[0062] (2) Calculated by mass percentage, mix aminophylline, sucrose, low-substituted hydroxypropyl methylcellulose, povidone K30, micropowder silica gel, and sucralose in proportion, and load it into a 3D printing rapid prototyping machine as a drug powder in the powder box.

[0063] (3) Put 50% ethanol solution into the cartridge.

[0064] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print aminophylline orally disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.2mm on the powder bed, and then prints the ...

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Abstract

The invention discloses a 3D printed aminophylline orally disintegrating tablet, which is mainly prepared by 3D printing technology from the following components in mass percentage: aminophylline 20-40%, filler 40-80%, disintegrant 0‑10%, binder 2%‑10%, micropowder silica gel 0.1‑1.0%, flavoring agent 0‑2%. The invention discloses a preparation method of the aminophylline orally disintegrating tablet. The orally disintegrating aminophylline tablet has a fast drug release rate, which can improve the compliance of patients in taking the drug, and is especially convenient for the elderly, children, and those with dysphagia to take.

Description

technical field [0001] The invention relates to an orally disintegrating tablet of aminophylline, in particular to a 3D printed orally disintegrating tablet of aminophylline. The invention also relates to a preparation method of the orally disintegrating aminophylline tablet. Background technique [0002] Three-dimensional printing technology (three dimension printing, 3DP) is a rapid prototyping technology based on digital models. The core idea of ​​3D printing first originated in the United States at the end of the 19th century, and it was not until the late 1980s that it was developed by the Massachusetts Institute of Technology. 3D printing technology is to design and construct a three-dimensional model on computer software based on the CAD model or CT data of the object. It can quickly and accurately manufacture objects with special shapes or complex internal structures. [0003] 3D printing technology was initially used in the fields of manufacturing, aerospace and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/24A61K31/522A61K47/04A61K47/32A61K47/10A61P11/06
CPCA61K9/0056A61K9/2009A61K9/2013A61K9/2027A61K9/2086A61K9/2095A61K31/522
Inventor 郑易
Owner 江苏互竑生物医学有限公司