Application of apigenin in preparation of drugs used for treating rheumatoid arthritis

A technology for arthritis and rheumatoid arthritis, applied in the field of preparation of drugs for the treatment of rheumatoid arthritis, can solve the problems of poor action selectivity, ulcers, and easy induction of infection, etc., and achieve the effect of highlighting substantive characteristics and strong inhibitory activity

Inactive Publication Date: 2018-03-27
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) are mainly used for treatment, but these drugs have obvious adverse reactions, such as the former damage Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection, etc.

Method used

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  • Application of apigenin in preparation of drugs used for treating rheumatoid arthritis
  • Application of apigenin in preparation of drugs used for treating rheumatoid arthritis
  • Application of apigenin in preparation of drugs used for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: the preparation of compound Apigenin tablet involved in the present invention:

[0015] Take 5 grams of the compound Apigenin, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0016] Embodiment 2: the preparation of compound Apigenin capsules involved in the present invention:

[0017] Take 5 grams of the compound Apigenin, add 195 grams of starch, mix well, and make 1000 capsules.

[0018] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0019] Experimental example 1, the influence of Apigenin of the present invention on rat adjuvant arthritis

[0020] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10 mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind paw of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally given Apigenin 5.0, 10.0, 20.0 mg / kg of the present invention, and the positive control group was orally given 10 mg of diclofenac / kg, the control group was given the same volume of distilled water, once a day, for 7 consecutive days, ...

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PUM

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Abstract

An Apigenin for treating immune inflammation is used to prepare a medicine for treating rheumatoid arthritis. Terfenadine and diclofenac are used as controls, and the curative effect of Apigenin is clear. The use of Apigenin involved in the present invention in the preparation of drugs for the treatment of rheumatoid arthritis is disclosed for the first time. Since the skeleton type belongs to a brand-new skeleton type, and its inhibitory activity against rheumatoid arthritis is so strong that it is unexpected, there is no evidence given by other compounds. The possibility of enlightenment has outstanding substantive features, and at the same time it is obviously a significant progress in the prevention and treatment of rheumatoid arthritis.

Description

technical field [0001] The invention relates to a new application of compound Apigenin, in particular to the application of Apigenin in the preparation of drugs for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a clinical common disease and frequently-occurring disease. Rheumatoid arthritis belongs to autoimmune disease and belongs to the category of immune inflammation. At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) are mainly used for treatment, but these drugs have obvious adverse reactions, such as the former damage Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection. Therefore, compounds with well-defined components, controllable quality, safety and high efficiency have potential value in the development of drugs for rheumatoid arthritis. [0003] The compound Apigenin invo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/48A61K9/20A61P29/00A61P19/02
CPCA61K31/352A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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