Application of apigenin in preparation of drugs used for treating rheumatoid arthritis
A technology for arthritis and rheumatoid arthritis, applied in the field of preparation of drugs for the treatment of rheumatoid arthritis, can solve the problems of poor action selectivity, ulcers, and easy induction of infection, etc., and achieve the effect of highlighting substantive characteristics and strong inhibitory activity
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Embodiment 1
[0014] Embodiment 1: the preparation of compound Apigenin tablet involved in the present invention:
[0015] Take 5 grams of the compound Apigenin, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.
Embodiment 2
[0016] Embodiment 2: the preparation of compound Apigenin capsules involved in the present invention:
[0017] Take 5 grams of the compound Apigenin, add 195 grams of starch, mix well, and make 1000 capsules.
[0018] The following pharmacodynamic experiments will further illustrate its drug activity.
experiment example 1
[0019] Experimental example 1, the influence of Apigenin of the present invention on rat adjuvant arthritis
[0020] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10 mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind paw of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally given Apigenin 5.0, 10.0, 20.0 mg / kg of the present invention, and the positive control group was orally given 10 mg of diclofenac / kg, the control group was given the same volume of distilled water, once a day, for 7 consecutive days, ...
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