Composition, preparation method of composition and application of composition to field of male sexual function improvement
A composition and product technology, applied in the field of improving male sexual function, the composition and its preparation field can solve problems such as health threats, and achieve the effects of improving sexual function, enhancing the number of captures, and increasing sperm motility rate.
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Embodiment 1
[0034] This embodiment is a specific example of the preparation of the product.
[0035] Weigh 20g Epimedium, 20g Morinda officinalis, 10g Psoralen, 2g Lycium barbarum, 15g Rehmannia glutinosa, 1g Cornus officinalis and 14g American ginseng, dissolve in extract solution 1 for extraction, stir and heat at 70°C for 60min, then filter Collect the liquid to obtain the first product 1; wherein, the extract 1 is 65% ethanol. The first product 1 was concentrated at 40°C for 40 minutes to obtain the second product 1. 60 g of the second product 1 was mixed with 10 g of auxiliary material 1, and spray-dried to obtain product 1; wherein, the extract 1 was 65% (v / v) ethanol Solution, excipient 1 is a mixture of maltodextrin and sodium starch glycolate.
[0036] Weigh 15g Epimedium, 15g Morinda officinalis, 2g Psoralen, 20g Lycium barbarum, 20g Rehmannia glutinosa, 10g Cornus officinalis and 1g American ginseng, dissolve in extract solution 2 for extraction, stir and heat at 85°C for 120m...
Embodiment 2
[0043] This example is a specific example of modeling, that is, artificial intervention is used to change normal rats into rats with sexual dysfunction.
[0044] After passing the animal quarantine, 200 male and female SD rats were randomly divided into 10 groups according to body weight, 20 / group, male and female, and the dosage of each group was 0.9g of the product to be tested / rat. Among them, Group 1 to Group 7 were given products 1 to 7 prepared in Example 1, Group 8 was given commercially available drugs for improving male sexual function, Group 9 was a model control group, and Group 10 was a blank control group.
[0045] After the rats were divided into groups, the blank control group underwent sham operation, and the rest of the groups underwent castration. During the operation, rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium at 1.5 mL / kg body weight, positioned supine, and prepared for skin preparation. A 1 cm long incision was made at t...
Embodiment 3
[0048] This example is a specific example of improving male sexual function by measuring the product prepared in Example 1.
[0049] 3.1 Experimental method
[0050] 3.1.1 General Observations
[0051] During the test period, the survival of the male mice was observed every day, including: diet, activity, hair, skin (ulcer, bleeding) and other conditions once.
[0052] 3.1.2 Mating test
[0053] At night after continuous administration for 30 days, the male mice were placed in the middle box in batches, 1 mouse / box, and after 5 minutes of adaptation to the environment, 1 female mouse was put into each box, and the mating behavior of the animals within 40 minutes was recorded, and then the video was analyzed to observe the following: index:
[0054] Capture latency period: the time from when the female rats were put in to when the male rats caught the female rats for the first time.
[0055] Latency of ejaculation: the time from the injection of female mice to the first eja...
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