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Chinese herbal medicine for treating osteoporosis, and preparation method of gel patch thereof

A technology for osteoporosis and gel patches, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of high toxic and side effects of chemical drugs and low patient tolerance , poor long-term curative effect and other problems, to achieve the formation of inhibition, solve the uncoordinated actions of drinking water and swallowing medication, and determine the effect of prevention and treatment

Active Publication Date: 2018-04-13
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a Chinese herbal medicine for the treatment of osteoporosis, which solves the problems of large toxic and side effects, increased burden on the kidneys, poor long-term curative effect and low patient tolerance of chemical drugs for the treatment of osteoporosis.

Method used

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preparation example Construction

[0034] The preparation method of the Chinese herbal medicine gel patch for the treatment of osteoporosis of the present invention is characterized in that, comprises the following steps:

[0035] Step 1, weighing and pretreatment of Chinese herbal medicine

[0036] Step 1.1, weigh 6-15 parts of Shen Jiang, 9-15 parts of Acanthopanax, 9-15 parts of Polygonatum, 6-15 parts of Xianlingpi, 5-15 parts of Achyranthes bidentata, 9-15 parts of Millipeda 15 parts, 9-15 parts of mulberry;

[0037] Step 1.2, mix the 7 kinds of drugs in step 1.1 and add them to the ethanol solution for soaking, reflux and extract once to obtain the first extraction solution and medicinal residues, and the first extraction solution for use; wherein the amount of the ethanol solution added is 1% of the total mass of the 7 kinds of medicinal materials. 6 to 8 times, the volume fraction of ethanol solution is 75 to 85%, the soaking time is 45 minutes, and the reflux extraction time is 60 minutes.

[0038] S...

Embodiment 1

[0049] Step 1: Weigh 15 parts of Shenjiang (1500g), 9 parts of Acanthopanax (900g), 15 parts of Polygonatum (1500g), 6 parts of Xianlingpi (600g), 10 parts of Achyranthes bidentata (1000g), 9 parts of chicken blood Rattan (900g), 9 parts of mulberry (900g), mix 7 kinds of medicinal materials, add 8 times the amount of 75% ethanol, soak for 45 minutes, reflux extraction for 60 minutes to extract once, and the extract is ready for use; add 6 times the amount to the dregs 65% ethanol, reflux extraction 2 times, 45 minutes each time, combine the 3 extracts, recover the ethanol under reduced pressure until there is no alcohol smell, obtain the extract, and set aside;

[0050] Step 2: Weigh 0.5 parts of sodium polyacrylate ViscomateNP-800 (50g), 2.5 parts of ViscomateNP-700 (250g), 0.65 parts of aluminum glycinate (65g), 0.11 parts of disodium edetate (11g), 3 parts of titanium dioxide Or ceramic powder or kaolin (300g), after mixing evenly, add to 45 parts of glycerin (4500g), and ...

Embodiment 2

[0056] Step 1: Weigh 6 parts of Shenjiang (600g), 15 parts of Acanthopanax (1500g), 9 parts of Polygonatum (900g), 15 parts of Xianlingpi (1500g), 5 parts of Achyranthes bidentata (500g), 15 parts of chicken blood Rattan (1500g), 15 parts of mulberry (1500g), mix 7 herbs, add 6 times the amount of 85% ethanol, soak for 45 minutes, reflux extraction for 60 minutes to extract once, and the extract is for later use; add 8 times the amount to the medicinal residue 45% ethanol, reflux extraction 2 times, 45 minutes each time, combine the 3 extracts, recover the ethanol under reduced pressure until there is no alcohol smell, and obtain the extract for later use;

[0057] Step 2: Weigh 2.5 parts of sodium polyacrylate ViscomateNP-800 (250g), 0.5 parts of ViscomateNP-700 (50g), 0.25 parts of aluminum glycinate (25g), 0.05 parts of disodium edetate (5g), 8 parts of titanium dioxide Or ceramic powder or kaolin (800g), after mixing evenly, add to 60 parts of glycerin (6000g), and stir fo...

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Abstract

A Chinese herbal medicine for treating osteoporosis, disclosed in the invention, comprises, by mass, 6-15 parts of Rhizoma Drynariae, 9-15 parts of Manyprickle Acathopanax Root, 9-15 parts of Polygonatum sibiricum, 6-15 parts of epimedium herb, 5-15 parts of Achyranthes bidentata, 9-15 parts of Caulis Spatholobi and 9-15 parts of mulberry. A preparation method of a gel patch comprises the following steps: carrying out refluxing extraction on Chinese herbal medicines by using ethanol to obtain extract products; and stirring and mixing the extract products and medicinal auxiliary materials, carrying out coating cutting, and standing the obtained material to obtain the gel patch. The gel patch has the efficacy of nourishing the liver and the kidney, replenishing essence and producing marrow,eliminating blood stasis and relaxing veins, and strengthening tendons and bones, and active components of medicines are transdermally absorbed by the Shenque acupoint of a patient, and show the prevention and treatment effects on osteoporosis by promoting differentiation and propagation of osteoblasts and inhibiting the formation of osteoclasts. The gel patch has the characteristics of convenience in use, good safety and reliability, long-acting slow release and reduction of the administration frequency, and provides a new way for the prevention and treatment of the osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a Chinese herbal medicine for treating osteoporosis, and also relates to a preparation method of a Chinese herbal medicine gel patch for treating osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic bone metabolic disease characterized by decreased bone mass, decreased bone density, damaged and degraded bone microstructure, increased bone fragility, and susceptibility to fracture. OP is mainly divided into three categories: postmenopausal osteoporosis, senile osteoporosis, and idiopathic osteoporosis. Among them, postmenopausal osteoporosis and senile osteoporosis mainly target the elderly. and postmenopausal women, other age groups also have the disease; idiopathic osteoporosis mostly occurs in pregnant and lactating women or adolescents. The occurrence of OP is related to disease factors, endocrine factors, nutritional sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/06A61K47/32A61P19/10
CPCA61K9/0014A61K9/06A61K36/126A61K36/21A61K36/254A61K36/296A61K36/486A61K36/605A61K36/8969A61K47/32A61K2236/333A61K2236/53A61K2300/00
Inventor 李伟泽赵宁付丽娜韩文霞张寒关丽
Owner XIAN MEDICAL UNIV
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