Pharmaceutical composition for treating acute pancreatitis and preparation method thereof
A technology of acute pancreatitis and composition, which is applied in the field of medicine and can solve the problems of increasing patients' pain and inconvenience of medication
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Embodiment 1
[0034] The preparation of embodiment 1 ointment of the present invention
[0035] Prescription of raw materials: 140 parts of rhubarb, 81 parts of baiji, 140 parts of Phellodendron cortex, 65 parts of black plum, 65 parts of mint, 30 parts of Angelica dahurica, 81 parts of Wujin, 65 parts of licorice.
[0036] 1. Extraction process
[0037] Weigh the four medicinal materials of rhubarb, Phellodendron cortex, licorice, and Angelica dahurica, add 12 times the volume of the medicinal materials in 40% v / v ethanol aqueous solution, heat and reflux for extraction, 1.5 hours each time, extract twice, filter, and combine twice filtrate to obtain alcohol extract;
[0038] Weigh the white and black plums of the prescription amount, add purified water of 12 times the volume of the medicinal materials, reflux extraction, each time for 1.5 hours, extract twice, filter, and combine the filtrates twice to obtain the water extract;
[0039] Concentrate the above-mentioned alcohol extraction...
experiment example 1
[0047] Experimental example 1 The comparison of the different base type properties of ointment of the present invention
[0048] In this experiment, three types of classical matrices were prepared, namely oily matrices, water-soluble matrices and emulsion matrices, for comparison.
[0049] 1. Oily blank matrix
[0050]①White petrolatum 9g; lanolin 1g
[0051] ②White petrolatum 5g; lanolin 5g
[0052] ③White petrolatum 1g; lanolin 9g
[0053] Preparation method: according to the above prescription, weigh a certain amount of white vaseline and lanolin base, heat and melt, stir evenly, and cool to get it. The results of the investigation of the matrix properties are shown in Table 1.
[0054] Table 1 Properties of oily blank matrix
[0055]
[0056] Result analysis: the blank matrix hardness of three kinds of prescription gained, applicability and cleanability three aspects difference are little, and matrix state is harder, and is difficult for cleaning, therefore is not ...
experiment example 2
[0088] The quality evaluation of ointment prepared with PEG as matrix under different dosages of experimental example 2
[0089] In this experiment, 10 experimental groups were set up, and the drug loading capacity and ointment quality of PEG400:PEG4000 (2:1) matrix were compared at different dosages. The results are shown in Table 4 and Table 5.
[0090] Table 4 Drug loading of PEG400:4000=2:1 matrix under different dosages
[0091]
[0092] The quality evaluation result of ointment of the present invention under the different dosages of table 5
[0093]
[0094] As can be seen from the above results, after the drug loading exceeds 24.63% (experimental group ⑥), the consistency of the ointment increases significantly, and the quality drops significantly, showing that the maximum drug loading of the ointment of the present invention is 24.63%, that is, the optimal formulation prescription is : PEG400:4000 weight ratio 2:1, drug loading is 24.63%.
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