Pharmaceutical composition for treating acute pancreatitis and preparation method thereof

A technology of acute pancreatitis and composition, which is applied in the field of medicine and can solve the problems of increasing patients' pain and inconvenience of medication

Active Publication Date: 2018-04-27
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned traditional Chinese medicine treatment medicines all need to be taken orally to exert a therapeutic effect, which is inconvenient to use and increases the pain of the patient.

Method used

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  • Pharmaceutical composition for treating acute pancreatitis and preparation method thereof
  • Pharmaceutical composition for treating acute pancreatitis and preparation method thereof
  • Pharmaceutical composition for treating acute pancreatitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 ointment of the present invention

[0035] Prescription of raw materials: 140 parts of rhubarb, 81 parts of baiji, 140 parts of Phellodendron cortex, 65 parts of black plum, 65 parts of mint, 30 parts of Angelica dahurica, 81 parts of Wujin, 65 parts of licorice.

[0036] 1. Extraction process

[0037] Weigh the four medicinal materials of rhubarb, Phellodendron cortex, licorice, and Angelica dahurica, add 12 times the volume of the medicinal materials in 40% v / v ethanol aqueous solution, heat and reflux for extraction, 1.5 hours each time, extract twice, filter, and combine twice filtrate to obtain alcohol extract;

[0038] Weigh the white and black plums of the prescription amount, add purified water of 12 times the volume of the medicinal materials, reflux extraction, each time for 1.5 hours, extract twice, filter, and combine the filtrates twice to obtain the water extract;

[0039] Concentrate the above-mentioned alcohol extraction...

experiment example 1

[0047] Experimental example 1 The comparison of the different base type properties of ointment of the present invention

[0048] In this experiment, three types of classical matrices were prepared, namely oily matrices, water-soluble matrices and emulsion matrices, for comparison.

[0049] 1. Oily blank matrix

[0050]①White petrolatum 9g; lanolin 1g

[0051] ②White petrolatum 5g; lanolin 5g

[0052] ③White petrolatum 1g; lanolin 9g

[0053] Preparation method: according to the above prescription, weigh a certain amount of white vaseline and lanolin base, heat and melt, stir evenly, and cool to get it. The results of the investigation of the matrix properties are shown in Table 1.

[0054] Table 1 Properties of oily blank matrix

[0055]

[0056] Result analysis: the blank matrix hardness of three kinds of prescription gained, applicability and cleanability three aspects difference are little, and matrix state is harder, and is difficult for cleaning, therefore is not ...

experiment example 2

[0088] The quality evaluation of ointment prepared with PEG as matrix under different dosages of experimental example 2

[0089] In this experiment, 10 experimental groups were set up, and the drug loading capacity and ointment quality of PEG400:PEG4000 (2:1) matrix were compared at different dosages. The results are shown in Table 4 and Table 5.

[0090] Table 4 Drug loading of PEG400:4000=2:1 matrix under different dosages

[0091]

[0092] The quality evaluation result of ointment of the present invention under the different dosages of table 5

[0093]

[0094] As can be seen from the above results, after the drug loading exceeds 24.63% (experimental group ⑥), the consistency of the ointment increases significantly, and the quality drops significantly, showing that the maximum drug loading of the ointment of the present invention is 24.63%, that is, the optimal formulation prescription is : PEG400:4000 weight ratio 2:1, drug loading is 24.63%.

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Abstract

The invention discloses a pharmaceutical composition for treating acute pancreatitis. The pharmaceutical composition is prepared from 120 to 180 parts by weight of rheum officinale, 73 to 109 parts byweight of rhizoma bletillae, 120 to 180 parts by weight of cortex phellodendri, 60 to 90 parts by weight of dark plum, 60 to 90 parts by weight of mint, 26 to 40 parts by weight of radix angelicae, 73 to 109 parts by weight of Blocks and 60 to 90 parts by weight of licorice root. The clinical research result shows that the pharmaceutical composition has effects of promoting blood circulation, removing blood stasis and promoting qi circulation to relieve pain and can promote elimination of acute pancreatitis and peripheral inflammatory response and the absorption of the accumulated liquid through external use. On the precondition of external treatment, an appropriate ointment base is used as a carrier and the ointment formula having the advantages of large drug load, good transdermal effects, simple preparation processes and use convenience is developed. The pharmaceutical composition provides a traditional Chinese medicine external preparation which is safe and effective and is easy to use.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating acute pancreatitis and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Acute pancreatitis refers to the inflammatory reaction of pancreatic tissue self-digestion, edema, hemorrhage and even necrosis after the activation of pancreatic enzymes due to various etiologies. Clinically, it is characterized by acute epigastric pain, nausea, vomiting, fever and increased blood trypsin. Acute pancreatitis is a very serious disease, and acute hemorrhagic and necrotizing acute pancreatitis is particularly dangerous, with rapid onset and high mortality, which seriously threatens the life and health of patients. [0003] In recent years, although the treatment of acute pancreatitis is still dominated by Western medicine supportive therapy, with the development of integrated Chinese and Western medicine, Chinese medicine is playing an increasingly impor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/06A61P1/18
CPCA61K9/0014A61K9/06A61K36/232A61K36/484A61K36/51A61K36/534A61K36/708A61K36/736A61K36/756A61K36/898A61K47/46A61K2300/00
Inventor 李为民费小凡宋毅徐珽董鉴霞
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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