Multivalent pneumococcal conjugate vaccine and preparation method thereof

Abstract

The invention provides a recombinant delta fHbp-NadA fusion protein carrier-based multivalent pneumococcal conjugate vaccine and a preparation method thereof. Through a flexible linker peptide chain,two active proteins are fused and expressed, activity of the two active proteins is kept and the active proteins are integrated into a single protein so that industrial production and immunization arecontrollable, a risk is greatly reduced and more polysaccharide-protein binding sites are provided.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a multivalent pneumococcal conjugate vaccine and a preparation method thereof. Background technique [0002] 1. Pathogenic microorganisms and vaccines [0003] Microorganisms that can cause infectious diseases in humans or animals are called pathogenic microorganisms or pathogenic microorganisms. Infection refers to the process of pathogenic microorganisms invading the body, growing and multiplying in certain parts, and causing a series of pathophysiological processes. When pathogenic microorganisms invade the body, the pathogenic microorganisms interact with the body and change each other's activity and function. Therefore, whether they can cause infectious diseases depends on the pathogenicity or virulence of the pathogenic microorganisms on the one hand, and on the other hand. Depends on the body's resistance, that is, immunity. The ability of pathogenic bacteria to...

AI Technical Summary

Problems solved by technology

The reason is that the total concentration of tetanus toxoid and diphtheria toxoid as carriers in the multivalent pneumococcal conjugate vaccine is too high, which will cause the carrier receptor competitive inhibition effect when inoculated at the same time with the combination vaccine containing DPT component. Reduced immunogenicity of the polysaccharide portion of the conjugated vaccine

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