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Marine biomaterial composite hydrogel dressing and preparation method thereof

A technology of composite hydrogel and marine organisms, which is applied in the field of marine biomaterial composite hydrogel dressing and its preparation, can solve the problems of easily infected scars, hyperplasia, slow wound healing speed, etc., and achieves multi-directional application and good curative effect. , to avoid the effect of toxic residues

Active Publication Date: 2018-05-11
海生健康科技(青岛)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to propose a marine biological material composite hydrogel dressing and its preparation method, which solves the problems of slow wound healing, susceptibility to infection and scar hyperplasia in alginate-based hydrogel dressings in the prior art

Method used

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  • Marine biomaterial composite hydrogel dressing and preparation method thereof
  • Marine biomaterial composite hydrogel dressing and preparation method thereof

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preparation example Construction

[0031] A preparation method of a marine biological material composite hydrogel dressing of the present invention comprises the following steps:

[0032] S1: Preparation of sodium alginate-fish collagen mixture

[0033] 1) Weighing sodium alginate, adding part of distilled water, stirring at 40-80°C for 20-60 minutes to dissolve it, and making a sodium alginate solution with a weight percentage of 1-40%;

[0034] 2) Weighing the fish collagen, adding the remaining distilled water, stirring for 5-90 minutes to dissolve it, and making a fish collagen solution with a weight percentage of 1-20%;

[0035] 3) Mix the fish collagen solution obtained in step 2) with the sodium alginate solution obtained in step 1) to obtain a mixed solution, weigh polyvinyl alcohol, sodium carboxymethyl cellulose, pectin, glycerin and propylene glycol, add and mix solution, stirred for 20-60 minutes, and degassed for 0.5-24 hours to obtain a sodium alginate-fish collagen mixture;

[0036] S2: Prepara...

Embodiment 1

[0045] A preparation method of a marine biological material composite hydrogel dressing of the present invention comprises the following steps:

[0046] S1: Preparation of sodium alginate-fish collagen mixture

[0047] 1) Weigh raw materials according to the following weight percentages: 0.5% sodium alginate, 0.5% fish collagen, 0.5% polyvinyl alcohol, 0.1% sodium carboxymethylcellulose, 0.1% pectin, 0.1% glycerin, 0.1% propylene glycol %, distilled water 98.1%;

[0048] 2) Weigh 0.5 g of sodium alginate, add 49.5 g of distilled water, and stir at 40° C. for 20 minutes to dissolve it to prepare a 1% sodium alginate solution by weight;

[0049] 3) Weigh 0.5 g of fish collagen, add the remaining distilled water, namely 48.6 g, stir for 5 minutes, and dissolve it to make a fish collagen solution with a weight percentage of 1%;

[0050] 4) Mix the fish collagen solution obtained in the above step 3) with the sodium alginate solution obtained in the above 2) to obtain a mixed sol...

Embodiment 2

[0064]A preparation method of a marine biological material composite hydrogel dressing of the present invention comprises the following steps:

[0065] S1: Preparation of sodium alginate-fish collagen mixture

[0066] 1) Weigh raw materials according to the following weight percentages: 20% sodium alginate, 2.5% fish collagen, 2.5% polyvinyl alcohol, 5% sodium carboxymethyl cellulose, 5% pectin, 10% glycerin, 20% propylene glycol %, distilled water 35%; fish collagen is the collagen extracted from the skin, scales and bones of tilapia and cod, and the molecular weight of fish collagen is 1000-2000 daltons.

[0067] 2) Weigh 20 g of sodium alginate, add 30 g of distilled water, and stir at 80° C. for 60 minutes to dissolve it to prepare a sodium alginate solution with a weight percentage of 40%;

[0068] 3) Weigh 2.5 g of fish collagen, add the remaining distilled water, namely 5 g, and stir for 90 minutes to dissolve it, and make a fish collagen solution with a weight percent...

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Abstract

The invention provides marine biomaterial composite hydrogel dressing and a preparation method thereof and relates to the technical field of medical dressing. The hydrogel dressing is prepared from asodium alginate-fish collagen mixed solution and a chitosan-crosslinking agent mixed solution, wherein the sodium alginate-fish collagen mixed solution is prepared from sodium alginate, fish collagen,polyvinyl alcohol, sodium carboxymethyl cellulose, pectin, glycerin, propanediol and distilled water; the chitosan-crosslinking agent mixed solution is prepared from chitosan, a crosslinking agent, glacial acetic acid and distilled water. The invention also provides the preparation method of the dressing. The sodium alginate-fish collagen mixed solution is cultured at the constant temperature, the chitosan-crosslinking agent mixed solution is added, the mixture reacts, and the hydrogel dressing is obtained. The hydrogel dressing has excellent mechanical property, moisture retention and biocompatibility, accelerates wound repairing, can diminish inflammation and perform sterilization, has no wound inflammation reaction, effectively promotes wound healing, is easy to remove and does not stick to a wound surface.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a marine biological material composite hydrogel dressing and a preparation method thereof. Background technique [0002] Traditional medical dressings, such as gauze and cotton pads, have many shortcomings in wound care. They have no moisturizing effect, and granulation tissue is easy to grow into the gauze mesh, resulting in adhesion and scab. Moreover, when the dressing is soaked, it is easy to cause exogenous infection, thus cause secondary damage. In recent years, scientific and technological workers have developed a new type of wound dressing, that is, hydrogel medical dressing. Compared with traditional medical dressings, hydrogel dressing can promote better wound healing, does not adhere to the wound surface, and reduces the pain of patients. Improves the microenvironment of the wound and inhibits the growth of bacteria. [0003] Hydrogel medical dressing produ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0033A61L26/0061A61L26/0066A61L26/008A61L26/009A61L2300/232A61L2300/252A61L2300/402A61L2300/41A61L2300/412A61L2300/418C08L5/04C08L5/08C08L29/04C08L1/286C08L5/06
Inventor 宋文山李八方杜芬于德君王园园代元坤
Owner 海生健康科技(青岛)有限公司
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