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Beverage composition comprising nanoencapsulated oxygen

A technology of nano-encapsulation and composition, applied in the direction of drug combination, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as environment and toxicity, achieve the effect of improving efficiency, reducing infection risk, and increasing the scope of use

Inactive Publication Date: 2018-05-11
OXFORD UNIV INNOVATION LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this fluid uses perfluorocarbons, which pose potential environmental and toxic risks

Method used

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  • Beverage composition comprising nanoencapsulated oxygen
  • Beverage composition comprising nanoencapsulated oxygen
  • Beverage composition comprising nanoencapsulated oxygen

Examples

Experimental program
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Embodiment Construction

[0111] Our formulations are designed to be compatible with existing microbubble formulations (intended for use as artificial respiration aids, e.g. http: / / www.ncbi.nlm.nih.gov / pmc / articles / PMC3563146 / ) and nanobubble water (http: / / www.cheml.com / CQ / oxyscams.html) provides increased stability of oxygen in suspension compared to This reduces the need for very short periods of time between preparing and consuming the beverage, and improves the efficiency with which oxygen can be absorbed from the digestive tract into the bloodstream and surrounding tissues. Being able to administer it orally (as opposed to intravenously) would reduce the risk of infection in hospitalized patients and greatly increase the reach of the product for consumer applications.

[0112] The present study has demonstrated a sustained increase in oxygen levels (>20 minutes) in hypoxic tumors following oral delivery, which had not been demonstrated before other therapeutic approaches. This differs from microb...

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Abstract

The invention relates to a beverage composition comprising: water; oxygen bubbles; a surfactant in an amount of between about 0.1 % (v / v) and about 0.5 % (v / v);one or more viscosity modifying agent(s)in an amount of between about 0.5 % (v / v) and about 2.5 % (v / v); and optionally citric acid in an amount of between about 0.1 % (v / v) and about 0.5 % (v / v). The invention further relates to compositions, methods of treatment for cancer, the composition for use in treatment of cancer, and the manufacture of the composition.

Description

technical field [0001] The present invention relates to beverage compositions for oral administration of oxygen and uses thereof. Background technique [0002] As tumors grow, blood supply to cancer cells may become insufficient due to insufficient supply of vasculature, resulting in low or irregular oxygen delivery and tumor hypoxia. Normally, cells die in the absence of oxygen. However, cancer cells can adapt to hypoxic environments through mutations. This tissue hypoxia is a common feature of solid tumors, and cells in these hypoxic areas can be resistant to both radiation and chemotherapy. It is increasingly recognized that effective anticancer therapies can exploit this tissue state to help combat the disease. Specifically, one approach to exploit tumor hypoxia in anticancer therapy is the local delivery of oxygen to hypoxic tumors in conjunction with chemotherapy, radiation therapy, photodynamic therapy, or sonodynamic therapy. This therapy has been studied with in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/107A61K33/00A61K47/10A61K47/24
CPCA61K47/10A61K47/24A61K9/1075A61K33/00A61K9/0095A61P35/00A61K47/12
Inventor 埃莉诺·斯特赖德乔舒亚·欧文雷·阿韦尔
Owner OXFORD UNIV INNOVATION LTD