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A kind of high-strength natural polymer hydrogel film and preparation method thereof

A natural polymer, hydrogel technology, used in prosthesis, surgery, medical science and other directions, can solve problems such as mechanical strength gap, and achieve good biocompatibility, excellent mechanical properties, and good cytocompatibility.

Active Publication Date: 2020-06-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with biofilms (such as dura mater) in the human body, there is still a large gap in mechanical strength.

Method used

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  • A kind of high-strength natural polymer hydrogel film and preparation method thereof
  • A kind of high-strength natural polymer hydrogel film and preparation method thereof
  • A kind of high-strength natural polymer hydrogel film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Dissolve 0.04g kappa carrageenan in 1wt% dilute acetic acid solution and dilute to 100mL; dissolve 0.36g chitosan with a degree of deacetylation of 85% in 1wt% dilute acetic acid solution and dilute to 100mL; To the solution containing 50mL of 1wt% dilute acetic acid, respectively drop the prepared 0.4mg / mL carrageenan solution and 3.6mg / mL chitosan solution, while vigorously magnetic stirring, to obtain a translucent uniform solution; After the above mixed solution removes bubbles, it is transferred to a petri dish with a diameter of 150mm, and the solvent is evaporated at a constant temperature at 70°C, and finally to a dry film; the resulting dry film is immersed in a large amount of deionized water to reach an equilibrium state When the carrageenan / chitosan hydrogel film is obtained, the mass ratio of carrageenan / chitosan is w r = 1:9.

Embodiment 2

[0041] Dissolve 0.08g kappa carrageenan in 1wt% dilute acetic acid solution, and dilute to 100mL, mix well and let stand; dissolve 0.32g chitosan with 85% deacetylation degree in 1wt% dilute acetic acid solution Add the prepared 0.8mg / mL carrageenan solution and 3.2mg / mL chitosan solution to the solution containing 50mL of 1wt% dilute acetic acid. Stir vigorously to obtain a uniform and translucent mixed solution; after removing bubbles from the above mixed solution, transfer to a petri dish with a diameter of 150 mm, and at the same time evaporate the solvent at a constant temperature at 70°C, and finally to a dry film; When the dry film is immersed in a large amount of deionized water and reaches the equilibrium state, a carrageenan / chitosan hydrogel film is obtained, wherein the mass ratio of carrageenan / chitosan is w r = 2:8.

Embodiment 3

[0043] Dissolve 0.12g kappa carrageenan in 1wt% dilute acetic acid solution and dilute to 100mL; dissolve 0.28g chitosan with a degree of deacetylation of 85% in 1wt% dilute acetic acid solution and dilute to 100mL; Add the prepared 1.2mg / mL carrageenan solution and 2.8mg / mL chitosan solution to the 50mL 1wt% dilute acetic acid respectively, while vigorously magnetic stirring, to obtain a white mixed solution; After the above mixed solution removes bubbles, it is transferred to a petri dish with a diameter of 150mm, and the solvent is evaporated at a constant temperature at 70°C, and finally to a dry film; the resulting dry film is immersed in a large amount of deionized water to reach an equilibrium state Time, the carrageenan / chitosan hydrogel film is obtained, wherein the mass ratio of carrageenan / chitosan is w r =3:7, the SEM image is as figure 1 As shown in the figure, it can be seen that a large number of nano-sized particles are filled in the gel matrix. These nano-sized ...

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Abstract

The invention discloses a high-strength natural high-molecular hydrogel film which is prepared from carrageenan and chitosan through ionic bond bonding and hydrogen bond bonding; maximal breaking stress of the hydrogel film is not smaller than 6.7 MPa, and maximal elongation is not smaller than 120%. The invention further discloses a preparation method for the high-strength natural high-molecularhydrogel film, and the preparation method comprises the following steps: uniformly mixing a dilute acetic acid solution of carrageenan and chitosan at room temperature to obtain a white mixed solutionsystem; transferring the mixed solution into a flat-bottom container, and performing vacuum drying at a temperature of 70-90 DEG C, thereby obtaining a dry-state film; soaking the dry-state film intodeionized water to reach swelling balance, thereby obtaining a carrageenan / chitosan hydrogel film. The high-strength natural high-molecular hydrogel film prepared is transparent, is uniform, is goodin toughness, is strong in cell adhesion resistance, and can be applied to the medical field as a biological diaphragm material.

Description

Technical field [0001] The invention belongs to the field of biopolymers, and specifically relates to a high-strength natural polymer hydrogel film and a preparation method thereof. Background technique [0002] There are a large number of biofilms around human organs and tissues, such as the dura mater, periosteum, and fascia. These films usually have excellent mechanical properties, such as the dura mater, which has a breaking strength of 4-6MPa and a breaking strain. About 110%; in the field of biomaterials, it is an important and practical issue to develop alternative materials with mechanical properties that match the human body's own membranes to repair the damage of their own tissues. [0003] At present, the substitute materials for the dura mater in surgery are mainly bovine pericardium and autologous membrane. However, the bovine pericardium is opaque, and chemical reagents are used in the process; the use of self-tissue membranes will cause secondary damage, and the sou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/50A61L27/52A61L31/04A61L31/14
CPCA61L27/26A61L27/50A61L27/52A61L31/041A61L31/14A61L31/145C08L5/00C08L5/08
Inventor 吴子良虞海超郑强
Owner ZHEJIANG UNIV