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New process for producing D-tryptophan by chemical method and enzymic method

A technology of tryptophan and chemical method, which is applied in the new process field of producing D-tryptophan by chemical method and enzymatic method, can solve the problems of non-recycled by-products, unfavorable safety and environmental protection, low production efficiency, etc. Short route, simple production process, and the effect of improving production efficiency

Active Publication Date: 2018-06-01
NANTONG ZILANG BIOPHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production efficiency of the existing technology is low, the mother liquor and by-products in the production process have not been reused, the consumption of raw materials is large, and organic matter is used as a solvent, which is not conducive to the current safety and environmental protection requirements

Method used

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  • New process for producing D-tryptophan by chemical method and enzymic method

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Experimental program
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Effect test

Embodiment 1

[0021] A new process of chemical and enzymatic production of D-tryptophan, including racemization, resolution, acetyl-DL-tryptophan refining, hydrolysis, D-tryptophan hydrochloride refining, decomplexation and mother liquor The processing step is to complete the synthesis process; the specific steps are as follows:

[0022] (1) Racemization: Put 107kg L-tryptophan, 428kg water, 214kg acetic anhydride and 53.5kg sodium hydroxide into the racemization reaction kettle. When the raw materials are added dropwise, the temperature is controlled below 50°C. Insulate and react at 45°C for 5 hours, then cool to below 40°C, adjust the pH value in the reaction kettle with hydrochloric acid, cool to below 30°C, centrifuge to obtain the filter cake as acetyl-DL-tryptophan, and send the mother liquor after racemization to To water treatment to be recycled;

[0023] (2) Splitting: Add 128kg of acetyl-DL-tryptophan prepared in step (1), 432kg of water and 54kg of sodium hydroxide to the split...

Embodiment 2

[0030] A new process of chemical and enzymatic production of D-tryptophan, including racemization, resolution, acetyl-DL-tryptophan refining, hydrolysis, D-tryptophan hydrochloride refining, decomplexation and mother liquor The processing step is to complete the synthesis process; the specific steps are as follows:

[0031] (1) Racemization: Put 533kgL-tryptophan, 2132kg water, 1066kg acetic anhydride and 266.5kg sodium hydroxide into the racemization reaction kettle. When the raw materials are added dropwise, the temperature is controlled below 50°C. Insulate and react at 45°C for 5 hours, then cool to below 40°C, adjust the pH value in the reaction kettle with hydrochloric acid, cool to below 30°C, centrifuge to obtain the filter cake as acetyl-DL-tryptophan, and send the mother liquor after racemization to To water treatment to be recycled;

[0032] (2) Splitting: add 640kg of acetyl-DL-tryptophan prepared in step (1), 2560kg of water and 320kg of sodium hydroxide to the s...

Embodiment 3

[0039] A new process of chemical and enzymatic production of D-tryptophan, including racemization, resolution, acetyl-DL-tryptophan refining, hydrolysis, D-tryptophan hydrochloride refining, decomplexation and mother liquor The processing step is to complete the synthesis process; the specific steps are as follows:

[0040] (1) Racemization: Put 320kgL-tryptophan, 1280kg water, 640kg acetic anhydride and 160kg sodium hydroxide into the racemization reaction kettle. Insulate and react at ℃ for 5 hours, then cool to below 40℃, adjust the pH value in the reaction kettle with hydrochloric acid, cool to below 30℃, centrifuge to obtain the filter cake as acetyl-DL-tryptophan, and send the mother liquor after racemization to Water treatment to be recycled;

[0041] (2) Splitting: Add 384kg of acetyl-DL-tryptophan prepared in step (1), 1536kg of water and 192kg of sodium hydroxide to the splitting reactor, raise the temperature to 80°C for 2 hours, then cool to 30°C Below ℃, centrif...

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Abstract

The invention discloses a new process for producing D-tryptophan by a chemical method and an enzymic method. The process is characterized in that the process comprises the following steps: racemization, resolution, refining of N-acetyl-DL-tryptophan, hydrolysis, refining of D-tryptophan hydrochloride, decomplexation, and treatment of mother liquor. The process is characterized in that the production process with combination of the chemical method and the enzymic method comprises racemization, resolution, refining and hydrolysis of L-tryptophan and refining of D-tryptophan hydrochloride, and D-tryptophan is obtained, and production efficiency is improved; mother liquor generated in the synthesis process is condensed, cyclic utilization is carried out, discharge capacity of the mother liquoris reduced, yield of the product is improved, and at the same time by-products are decomplexed and cyclic utilization is carried out, and waste of resource is reduced; in the synthesis process, wateris used as a solvent, in order to solve the defect that organic matters are used as solvents in the conventional methods with safety and environmental protection; extra racemase and resolving agentsare not needed to add, the process route is short, and production process is simple.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a new process for producing D-tryptophan by chemical and enzymatic methods. Background technique [0002] D-Tryptophan, also known as aminoindole propionic acid, is a white or off-white to slightly yellow crystalline powder, odorless and sweet, slightly soluble in water, insoluble in genetics, soluble in enoic acid or enoic acid , coloring when exposed to light for a long time, and a small amount of indole is produced when heated with water. D-tryptophan, as an important amino acid necessary for the human body, is widely used in medical and food purposes, how to apply it in amino acid infusion, comprehensive amino acid preparations, nutritional supplements for pregnant women and special milk powder for infants, synthetic melatonin, food Additives etc. [0003] Chinese patent CN104830945A, the present invention discloses a production process for producing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P41/00C12P13/22C07D209/20
CPCC07D209/20C12P13/227C12P41/001
Inventor 朱滁县秦振华
Owner NANTONG ZILANG BIOPHARMA TECH CO LTD
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