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Method for extracting and preparing panax notoginseng saponins from fresh panax notoginseng

The technology of total saponins of Panax notoginseng and Panax notoginseng is applied in the field of extraction and preparation of active components of plants, and can solve the problems of high impurity content, easy inactivation of total saponins of Panax notoginseng, and low purity of total saponins of Panax notoginseng.

Active Publication Date: 2018-06-08
楚雄云植药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the deficiencies of the prior art, the present invention provides a method for extracting and preparing total notoginseng saponins from fresh notoginseng, which is used to solve the problems of easy inactivation of total notoginseng saponins, high impurity content, and low purity of total notoginseng saponins

Method used

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  • Method for extracting and preparing panax notoginseng saponins from fresh panax notoginseng

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take fresh Panax notoginseng as the feed material, add 75% v / v ethanol homogenate which is 10 times the weight of fresh Panax notoginseng to the fresh Sanqi 75% v / v ethanol homogenate, after homogenization, let it stand for 24h, filter to obtain filtrate II, combine filtrate I and filtrate II, and filter with suction until the filtrate is clear to obtain filtrate III; put filtrate III at a temperature ≤ 60°C and 0.08Mpa Concentrate until there is no alcohol smell to obtain the concentrated solution I; add water 8 times the weight of the concentrated solution I to the concentrated solution I to dilute the upper D101 macroporous adsorption resin, add fresh Panax notoginseng with 8 times the weight of water (that is, add 8 times the weight of the feed) weight of water), washed with water, and then 75% v / v ethanol eluate of 8 times the weight of fresh Panax notoginseng to obtain the ethanol eluate, and the ethanol eluate was passed through the decolorizing resin and then con...

Embodiment 2

[0033] Take fresh Panax notoginseng as the feed material, add 75% v / v ethanol homogenate of 8 times the weight of fresh Panax notoginseng to the fresh Panax notoginseng, let it stand for 24 hours after homogenization, filter to obtain filtrate I, and add 6 times the weight of the filter residue to the filter residue 75% v / v ethanol homogenate, after homogenization, let it stand for 24h, filter to obtain filtrate II, combine filtrate I and filtrate II, and filter with suction until the filtrate is clear to obtain filtrate III; put filtrate III at a temperature ≤ 60°C and 0.08Mpa Concentrate until there is no alcohol smell to obtain the concentrated solution I; add the concentrated solution I to water 6 times the weight of the concentrated solution I to dilute the upper AB-8 macroporous adsorption resin, add water 6 times the weight of the feed, wash with water, and add 6 times the weight of the feed. Double the weight of 85% v / v ethanol to obtain the ethanol eluate, the ethanol ...

Embodiment 3

[0035]Take fresh Panax notoginseng as the feed material, add 75% v / v ethanol homogenate which is 8 times the weight of fresh Panax notoginseng to the fresh Panax notoginseng, let it stand for 12 hours after homogenization, filter to obtain filtrate I, add 5 times the weight of the filter residue to the filter residue 75% v / v ethanol homogenate, after homogenization, let it stand for 12h, filter to obtain filtrate II, combine filtrate I and filtrate II, and filter with suction until the filtrate is clear to obtain filtrate III; put filtrate III at a temperature ≤ 60°C and 0.08Mpa Concentrate until there is no alcohol smell to obtain the concentrated solution I; add the concentrated solution I to water 5 times the weight of the concentrated solution I to dilute the upper D101 macroporous adsorption resin, add water 5 times the weight of the feed, wash with water, and add 6 times the weight of the feed Wash with 80% v / v ethanol to obtain ethanol eluate, and then concentrate the et...

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Abstract

The invention discloses a method for extracting and preparing panax notoginseng saponins from fresh panax notoginseng. The method is characterized in that the fresh panax notoginseng is used as raw materials; ethyl alcohol is added into the fresh panax notoginseng for homogenating; filtering and concentration are performed until no alcohol taste exists; macroporous adsorbent resin is used; refining, active carbon decoloration and drying are performed to obtain a target product. The fresh panax notoginseng is used as raw materials for extraction; the panax notoginseng saponin yield is improvedby a homogenating method; the content of all ingredients of the panax notoginseng saponins is improved through cold extracting extraction; the loss of the panax notoginseng saponins in the preparing panax notoginseng drying process, the smashing process and high-temperature backflow extraction process is reduced. The method is simple and convenient; the method can be widely applied to industrial production of panax notoginseng saponins.

Description

technical field [0001] The invention relates to a method for extracting and preparing total saponins of notoginseng from fresh notoginseng, and belongs to the technical field of extraction and preparation of plant active ingredients. Background technique [0002] Panax notoginseng, a traditional Chinese medicinal material, is the dry root and rhizome of Panax notoginseng (Burk.) F.H.Chen, an Araliaceae plant. Efficacy, mainly produced in Wenshan Prefecture, Yunnan, so it is named Wenshan Sanqi, also known as Wenzhou Sanqi. The main components of notoginseng are: notoginseng total saponins, notoginseng, flavonoids, notoginseng polysaccharides, volatile oil, etc. The most important active ingredient is Panax notoginseng saponins, the content of total saponins (PNS) can reach 12%. Panax notoginseng saponins are widely used, mainly in medicines and health care products for cardiovascular and cerebrovascular diseases, such as "Xuesaitong" and "Compound Danshen Dripping Pills". ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K125/00
CPCA61K36/258A61K2236/333A61K2236/39A61K2236/55
Inventor 毕荣璐赵锋宁郭文
Owner 楚雄云植药业有限公司