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Gujin pill pellet and preparation method thereof

A technology of Gujin Pill pellets and Gujin Pills is applied in the directions of skeletal diseases, pharmaceutical formulations, medical preparations containing active ingredients, etc. effect of storage

Active Publication Date: 2011-02-09
GUIZHOU JINGCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a kind of Gujin pill pellet and its preparation method, to provide a new Gujin pill preparation that is not easy to absorb moisture, easy to store, stable in quality, and easy to fill, so as to solve the problem that Gujin pill is easy to absorb moisture. question

Method used

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  • Gujin pill pellet and preparation method thereof
  • Gujin pill pellet and preparation method thereof
  • Gujin pill pellet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 (preparation of bone tendon pellets of the present invention)

[0039] Prepare the Gujin Wan pellet sample according to the following steps:

[0040] (1) Extract dry powder of Gujin Wan extract:

[0041] 91 parts by weight of turmeric, 46 parts by weight of cassia twig, 183 parts by weight of cloves, 27 parts by weight of woody fragrance and 70% ethanol for reflux extraction twice, each time for 7 hours, filtering, combining the filtrates, and recovering ethanol to obtain an ethanol extract; Add 46 parts by weight of Achyranthes bidentata, 183 parts by weight of Gentiana chinensis, 46 parts by weight of safflower, and 91 parts by weight of white peony, add water and decoct twice, each time for 2 hours, filter, combine the filtrates, let stand, take the supernatant and extract with ethanol Liquids are combined, concentrated to a thick paste with a relative density of 1.28 to 1.30 at 80°C, dried, and ground into fine powder to obtain dry powder of Gujinwan e...

Embodiment 2

[0052] Embodiment 2 (preparation of bone tendon pellets of the present invention)

[0053] According to the method described in Example 1, the Gujin Wan pellet sample of the present invention was prepared, except that 4.00 parts by weight of Gujin Wan extract dry powder was used in step (3).

[0054] Place RH as MgCl after filling the obtained Gujinwan pellet sample in the capsule 2 .6H 2 O (33% relative humidity), K 2 CO 3 .2H 2 O (42.76% relative humidity), NaBr.2H 2 O (relative humidity: 57.7%), NaCl (relative humidity: 75.28%) in a glass desiccator, at room temperature 25 ° C for 10 days. Investigate the hygroscopicity and filling properties of each sample under different conditions, the test results are shown in Table 1, Table 2 and figure 1 .

[0055] The moisture absorption results of each sample under different relative humidity conditions in table 1

[0056]

[0057] Filling properties of each sample in Table 2

[0058]

[0059] Through hygroscopicity a...

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Abstract

The invention relates to a Gujin pill pellet and a preparation method thereof. The Gujin pill pellet contains Gujin pill extractum dry powder and Gujin pill mixed powder, wherein the weight ratio of the Gujin pill extractum dry powder to the Gujin pill mixed powder is 3.76-4.00: 1.86-2.14, and the size of the pellet is 16-30 meshes. The Gujin pill pellet is a novel iliacus pill preparation which does not absorb moisture, is easy to store and fill and has stable quality, and can solve the problem of moisture absorption in the traditional iliacus pill.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a solid preparation, in particular, the invention relates to Gujinwan pellets and a preparation method thereof. Background technique: [0002] In the technical field of preparation of solid preparations of traditional Chinese medicine, when the drug powder is placed in the air with high humidity, it is easy to have different degrees of hygroscopic phenomenon, so that the fluidity of the powder will decrease, solidify, wet, liquefy, etc., and even promote the chemical process. reaction to reduce the stability of the drug. Moisture absorption is a phenomenon that often occurs in solid preparations of traditional Chinese medicine, especially for solid preparations of traditional Chinese medicine that contain dry extracts of traditional Chinese medicine in the process, such as tablets, capsules, granules, etc. Moisture has a great impact on the stability of solid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P19/08A61P29/00A61P19/02A61K9/16
Inventor 马贤鹏欧邦露张永
Owner GUIZHOU JINGCHENG PHARMA
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