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Nano-encapsulated retinol anti-acne gel and production method thereof

A technology of yellow aldehyde for removing acne and retinal, which can be used in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc. It can solve the problems of retinal instability, strong irritation, and difficult storage, and achieve remarkable therapeutic effects , The preparation process is simple, and the effect of avoiding irritation

Active Publication Date: 2017-09-15
程刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there is no technology to directly apply retinal to acne and acne scars at present, because acne and acne scars itself is a staged process, and retinoic acid is generally used for treatment now, and its irritating strong, side effects
Due to the instability of retinal, retinal is easily oxidized to retinoic acid during application, and retinal is easily oxidized and reduced, and it is not easy to store
This also makes the application of retinal in acne and acne marks a technical problem.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 0.5 parts by weight of retinal; 1 part by weight of vitamin C; 1 part by weight of phospholipid; 20 parts by weight of polyethylene glycol-20 10 parts by weight of caprylic triglyceride or capric triglyceride; 10 parts by weight of glycerin; 5 parts by weight of water.

[0055] The preparation method of the present embodiment comprises the following process steps:

[0056] S1. Weigh each component, add glyceryl phosphate, polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin into the container, and ultrasonicate for 5 minutes until completely dissolved; heat in a water bath, and heat in a water bath The temperature is 75°C, heated for 30 minutes, and ethanol is added thereto to obtain a solution;

[0057] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 50°C. The retinal is made into powder at ...

Embodiment 2

[0060] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 5 parts by weight of retinal; 3 parts by weight of vitamin C; 20 parts by weight of phospholipids; 40 parts by weight of polyethylene glycol-20 20 parts by weight of caprylic triglyceride or capric triglyceride; 30 parts by weight of glycerin; 10 parts by weight of water.

[0061] The preparation method of the present embodiment comprises the following process steps:

[0062] S1. Weigh each component, add phospholipid (phosphoglyceride), polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin to the container, ultrasonicate for 7 minutes until completely dissolved; heat in a water bath , the temperature of the water bath heating is 85 ° C, heating for 40 minutes, and adding ethanol thereinto to obtain a solution;

[0063] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 60°C. The retinal is made ...

Embodiment 3

[0066] A nano-encapsulated retinal liposome, which is made of the following raw materials by weight percentage: 2.5 parts by weight of retinal; 2 parts by weight of vitamin C; 10 parts by weight of phospholipid; 30 parts by weight of polyethylene glycol-20 15 parts by weight of caprylic triglyceride or capric triglyceride; 20 parts by weight of glycerin; 7 parts by weight of water.

[0067] The preparation method of the present embodiment comprises the following process steps:

[0068] S1. Weigh each component, add phospholipid (phosphoglyceride), polyethylene glycol-20, caprylic triglyceride or capric triglyceride, and glycerin to the container, ultrasonicate for 6 minutes until completely dissolved; heat in a water bath , the temperature of the water bath heating is 80 ° C, heating for 35 minutes, and adding ethanol thereinto to obtain a solution;

[0069] S2. Slowly inject the solution obtained in step S1 into retinal at a constant temperature of 55°C. The retinal is made ...

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PUM

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Abstract

The invention discloses a nano-encapsulated retinol anti-acne gel and a production method thereof. The nano-encapsulated retinol anti-acne gel comprises, by weight, 0.5-5 parts of retinal, 1-3 parts of vitamin C, 1-20 parts of phospholipid, 20-40 parts of polyethylene glycol-20, 10-20 parts of caprylic triglyceride or capric triglyceride, 10-30 parts of glycerol and 5-10 parts of water. The production method of the nano-encapsulated retinol anti-acne gel is simple, and raw materials in the invention accord with cosmetic healthiness standards; and the nano-encapsulated retinol anti-acne gel has an obvious treatment effect on acnes in various stages, and is basically suitable for all people.

Description

technical field [0001] The invention relates to a cosmetic composition or a composition for skin diseases, in particular to a nano-encapsulated retinal acne gel and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous glands caused by multiple factors. The root cause is endocrine disorders, caused by exuberant androgen secretion. The cause of acne is also related to some pathogenic bacteria infections, and it has been confirmed that the occurrence of acne is related to the infection of Corynebacterium acnes propionii. This Corynebacterium acnes parasitizes in the pilosebaceous glands of adolescents. Through the action of lipase, it can hydrolyze triglycerides and produce more free fatty acids. These free fatty acids can cause non-specific inflammatory reactions in and around the hair follicles. When the inflammation is severe, pustules and cysts may appear. [0003] Retinoic acid drugs for external us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/11A61K31/4166A61K31/155A61K31/44A61K9/06A61K9/127A61K47/24A61P17/10A61K8/67A61K8/49A61K8/46A61K8/41A61K8/34A61K8/55A61K8/14A61K8/04A61Q19/10A61Q19/00
CPCA61K8/042A61K8/14A61K8/345A61K8/416A61K8/466A61K8/4946A61K8/553A61K8/671A61K9/06A61K9/127A61K31/11A61K31/155A61K31/4166A61K31/44A61Q19/00A61Q19/10
Inventor 程刚
Owner 程刚
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