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Drug for treating bronchitis and preparation method thereof

A technology for bronchitis and drugs, which is applied in the field of drugs for treating bronchitis and its preparation, can solve the problems of unclear pharmacological mechanism of action and low strength, and achieve improved respiratory vascular strength, good membrane permeability, and improved absorption Effect

Inactive Publication Date: 2018-07-13
覃静欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing literature, there are extensive reports on the pharmacological effects of mangiferin, including: relieving asthma, relieving cough, reducing phlegm, lowering blood sugar, antibacterial, anti-inflammatory, anti-lipid peroxidation, protecting liver and gallbladder, immune regulation, anti-allergic , anti-inflammatory, analgesic, anti-viral, central nervous system excitatory, cardiotonic, analgesic, antipyretic, anti-tumor, etc., but the intensity of each action is not outstanding, and the mechanism of pharmacological action is not clear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of orange peel extract

[0037] (1) Take the dried orange peel and put it in a high-speed pulverizer to pulverize it evenly, add 8mL / g orange peel powder with a concentration of 95% ethanol, keep it warm at 60°C for 2h, cool it to room temperature and carry out suction filtration, and put the filtrate in Vacuum concentration at 50°C to recover ethanol, repeated washing with petroleum ether, centrifugal separation, and vacuum concentration to completely remove ethanol to obtain orange peel extract;

[0038] Preparation of Esterified Mangiferin

[0039](2) Add dropwise 1.5% by volume of 98% H 2 SO 4 After dripping, add 5g / 10mL mangiferin of acetic anhydride, mix well to form a suspension; put this suspension in a 40°C electric heating constant temperature water bath, keep this temperature for 18h, and stir from time to time during the period to make the mangiferin All dissolved; after the reaction was completed, the reaction solution was directly poured int...

Embodiment 2

[0047] Preparation of orange peel extract

[0048] (1) Take the dried orange peel and put it in a high-speed pulverizer to pulverize it evenly, add 15mL / g orange peel powder with a concentration of 95% ethanol, keep it warm at 60°C for 4h, cool it to room temperature and carry out suction filtration, and put the filtrate in Vacuum concentration at 50°C to recover ethanol, repeated washing with petroleum ether, centrifugal separation, and vacuum concentration to completely remove ethanol to obtain orange peel extract;

[0049] Preparation of Esterified Mangiferin

[0050] (2) Add dropwise 2.5% by volume of 98% H 2 SO 4 After dripping, add 1g / 10mL mangiferin of acetic anhydride, mix well to form a suspension; put this suspension in a 40°C electric heating constant temperature water bath, keep this temperature for 18h, and stir from time to time during the period to make the mangiferin All dissolved; after the reaction was completed, the reaction solution was directly poured i...

Embodiment 3

[0058] Preparation of orange peel extract

[0059] (1) Take the dried orange peel and put it in a high-speed pulverizer to pulverize it evenly, add 10mL / g orange peel powder with a concentration of 95% ethanol, keep it warm at 60°C for 3h, cool it to room temperature and carry out suction filtration, and put the filtrate in Vacuum concentration at 50°C to recover ethanol, repeated washing with petroleum ether, centrifugal separation, and vacuum concentration to completely remove ethanol to obtain orange peel extract;

[0060] Preparation of Esterified Mangiferin

[0061] (2) In a water bath at room temperature and under constant stirring, add 2% by volume of 98% H 2 SO 4 After dripping, add 3g / 10mL mangiferin of acetic anhydride, mix well to form a suspension; put this suspension in a 40°C electric heating constant temperature water bath, keep this temperature for 18 hours, and stir from time to time during the period to make the mangiferin All dissolved; after the reaction...

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Abstract

The invention provides a drug for treating bronchitis and a preparation method thereof. The drug is prepared from esterified mangiferin, sodium houttuyfonate, acidized berberine, wormwood essential oil, an extract of orange peel, an extract of Guangxi leaf of strigose hydrangea and succinic acid, and the main components of mangiferin, berberine and various kind of essential oil are subjected to microencapsulation. Absorption of the drug by human body can be improved, the performing time of the drug can be longer through drug sustained release, the respiratory tract function can be effectivelyimproved so that respiration can be smooth, and meanwhile, the drug has the antiviral effect.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation for respiratory diseases, in particular to a medicine for treating bronchitis and a preparation method thereof. Background technique [0002] Bronchitis refers to chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues. The main cause of bronchitis is chronic non-specific inflammation of the bronchi formed by repeated infections of viruses and bacteria. When the temperature drops, the spasm and ischemia of small respiratory vessels, and the decline in defense function are conducive to pathogenesis; chronic stimuli such as smoke and dust and air pollution can also cause disease; smoking can cause bronchospasm, mucous membrane variation, decreased ciliary movement, and increased mucus secretion, which is conducive to infection; allergies factors are also relevant. In today's society, the environment is increasingly polluted, leading to more and more ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K36/752A61K9/50A61K47/46A61K47/44A61P11/00A61K31/7048A61K31/185A61K31/194A61K31/4375
CPCA61K31/185A61K9/0014A61K9/5015A61K9/5063A61K31/194A61K31/4375A61K31/7048A61K36/282A61K36/534A61K36/73A61K36/752A61K36/9068A61K2300/00
Inventor 覃静欣
Owner 覃静欣
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