Core-shell structured nanofibers prepared from gel-like oil-in-water type emulsion by electrospinning and method

An oil-in-water emulsion and electrospinning technology, which is applied in electrospinning, fiber treatment, fiber chemical characteristics, etc., can solve the problems of unsuitable hydrophobic drug loading, lack of cell biological functionality, and unsatisfactory repair effect , to achieve good biocompatibility and safety in use, low cost and mild conditions
CN108301068AActive Publication Date: 2018-07-20杭州犇鑫科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
杭州犇鑫科技有限公司
Publication Date
2018-07-20

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Abstract

The invention discloses a method for preparing core-shell structured nanofibers from gel-like oil-in-water type emulsion by electrospinning. The method comprises the following steps: (1) dissolving hydrophilic colloids in a solvent to obtain an aqueous phase solution; (2) adding an oil phase solution containing a hydrophobic active substance to the aqueous phase solution, and uniformly mixing thesolutions to obtain the gel-like oil-in-water type emulsion; (3) performing electrospinning on the gel-like oil-in-water type emulsion to obtain the core-shell structured nanofibers. The invention further discloses the core-shell structured nanofibers prepared with the method. The core-shell structured nanofibers have better biocompatibility and biodegradability due to adoption of the hydrophiliccolloids as a shell, and are applicable to entrapment of the hydrophobic active substance due to adoption of the oleophilic oil phase as a core.
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Description

technical field

[0001] The invention relates to the technical field of polymer materials, in particular to a nanofiber with a core-shell structure prepared by electrostatic spinning of a gel-like oil-in-water emulsion and a method thereof. Background technique

[0002] Electrospinning technology is that the polymer solution or melt overcomes the surface tension under the action of high-voltage static electricity, forms a Taylor (Taylor) cone at the spinneret, and ejects the polymer jet at high speed, and solidifies after mechanical stretching and solvent volatilization. A construction technique for nanofibrous structures. Electrospun fiber materials have the advantages of large specific surface area, good fiber continuity, small fiber membrane pore size, and high porosity. It can also be used as a drug carrier to improve drug stability and control drug release behavior, showing superior characteristics and great development potential.

[0003] Among them, emulsion electros...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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