A kind of silk fibroin/polylactic acid composite microporous membrane material and its preparation method and application

A technology of polylactic acid and microporous membranes, applied in prostheses, bandages, absorbent pads, etc., can solve the problems of reducing the biological activity of scaffold materials and limiting applications, and achieve the effects of low production cost, easy operation, and good interaction

Active Publication Date: 2022-07-08
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The above preparation methods of scaffold materials use more organic solvents, which greatly reduces the biological activity of scaffold materials and limits their application in tissue engineering.

Method used

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  • A kind of silk fibroin/polylactic acid composite microporous membrane material and its preparation method and application
  • A kind of silk fibroin/polylactic acid composite microporous membrane material and its preparation method and application
  • A kind of silk fibroin/polylactic acid composite microporous membrane material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Weigh 5.00g of cut silkworm cocoons, put them into 2000mL of 0.21wt% sodium bicarbonate boiling aqueous solution for 30min degumming treatment, and the liquor ratio of silkworm cocoons to sodium bicarbonate is 1.00g:400mL. After repeated washing with deionized water for 2-3 times, the degummed mulberry silk can be obtained by moving it to a ventilated place to dry naturally.

[0046] A calcium chloride-formic acid solution with a concentration of 4.00wt% was prepared, and then 498 mg of degummed mulberry silk was put into the calcium chloride-formic acid solution to dissolve, and mechanically shaken for 2min to obtain a mulberry silk protein solution with a concentration of 8.00wt%; The mulberry silk fibroin solution was filtered with an organic nylon 66 microporous filter membrane of 0.45 μm, which was the silk fibroin solution.

[0047] According to the silk fibroin and polylactic acid mass ratio of 1:5, weigh 2491 mg of L-polylactic acid (PLLA) with a molecular weigh...

Embodiment 2

[0051] Embodiment 2 is identical with the preparation method of embodiment 1, and the difference is that the pressure in the autoclave is 3MPa ( figure 1 c, 1c').

Embodiment 3

[0053] Embodiment 3 is identical with the preparation method of embodiment 1, and the difference is that the pressure in the autoclave is 4MPa ( figure 1 d, 1d').

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Abstract

The invention discloses a silk fibroin/polylactic acid composite microporous membrane material and a preparation method and application thereof. In the invention, the natural silk fibroin material and the polymer polylactic acid material are compounded in a certain proportion, and the silk fibroin of different mixing proportions with a certain porosity and controllable structure and mechanical properties is prepared by a solid solvent-free gas foaming method. /polylactic acid composite microporous membrane. The preparation method of the silk fibroin/polylactic acid composite microporous membrane material in the present invention has the advantages of non-toxicity, no residue, simple operation, etc., and the organic solvent or high temperature used in the traditional stent preparation method is avoided in the micropore preparation process; And according to the pressure of the foaming gas, the pore size and porosity of the composite microporous membrane material and its thermal stability and mechanical properties can be flexibly adjusted. The preparation of the invention can obtain a safe, non-toxic and degradable composite microporous membrane material, which can be used for tissue engineering, such as skin dressings, artificial blood vessels, bone scaffolds and the like.

Description

technical field [0001] The invention belongs to the field of processing methods for polymer materials, and in particular relates to a silk fibroin / polylactic acid composite microporous membrane material and a preparation method and application thereof. At the same time, this method can control the pore size and porosity, thermal stability and mechanical properties of the composite membrane. The invention is suitable for research and application in the fields of tissue engineering, biomedicine, food and the like. Background technique [0002] China is a major producer of silk, accounting for more than 70% of the world's silk production. Silk fibroin is the main component of silk. Silk fibroin not only has good biocompatibility and degradation properties, but also has the characteristics of easy processing and modification, non-toxic degradation products, and excellent physical and mechanical properties, so it has become an ideal biological Medical materials have been extens...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08J9/12C08L89/00C08L67/04A61L15/22A61L15/42A61L27/26A61L27/56
CPCC08J5/18C08J9/122A61L27/26A61L27/56A61L15/225A61L15/425C08J2367/04C08J2489/00C08J2389/00C08J2467/04C08J2203/06C08L89/00C08L67/04
Inventor 王昉李莹莹刘浩顾正桂
Owner NANJING NORMAL UNIVERSITY
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