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Cu-based flexible non-enzymatic lactic acid sensor electrode film and preparation method thereof

A sensor electrode, flexible technology, applied in the field of Cu-based flexible non-enzyme lactic acid sensor electrode film and its preparation, can solve the problems of inactivation, inability to monitor sweat lactic acid concentration, and affecting the stability of lactic acid sensor

Active Publication Date: 2021-09-10
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the lactase sensor has the following defects: the extraction of lactate oxidase is difficult and expensive, and its activity is obviously affected by environmental factors such as temperature, oxygen concentration, pH value, humidity, etc., for example, it will be significantly inactivated at room temperature, which is It will affect the stability, sensitivity and reproducibility of this type of lactic acid sensor, resulting in harsh storage and use conditions
However, it has the defect of narrow detection range and cannot be directly used for sweat lactic acid concentration monitoring

Method used

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  • Cu-based flexible non-enzymatic lactic acid sensor electrode film and preparation method thereof
  • Cu-based flexible non-enzymatic lactic acid sensor electrode film and preparation method thereof
  • Cu-based flexible non-enzymatic lactic acid sensor electrode film and preparation method thereof

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preparation example Construction

[0034] see figure 1 As shown, the invention provides a kind of preparation method of Cu-based flexible non-enzymatic lactic acid sensor electrode membrane, comprises the steps:

[0035] S1. Preparation of conductive BC / c-MWCNTs nanocomposite membrane: prepare c-MWCNTs suspension with a predetermined concentration; pretreat the BC membrane, and then soak the pretreated BC membrane in the c-MWCNTs suspension for ultrasonic treatment 4 ~6h, take it out and wash it, and prepare the conductive BC / c-MWCNTs nanocomposite film;

[0036] S2, preparation of BC / c-MWCNTs / PPy nanocomposite film: preparing pyrrole monomer solution; clamping the conductive BC / c-MWCNTs nanocomposite film with an electrode clamp as a working electrode, and using a platinum sheet electrode as a counter electrode, A saturated calomel electrode is used as a reference electrode, and the pyrrole monomer solution is used as an electrolyte to carry out electrochemical polymerization reaction, and after the polymeriz...

Embodiment 1

[0047] Embodiment 1 of the present invention provides a method for preparing a Cu-based flexible non-enzymatic lactic acid sensor electrode film, comprising the following steps:

[0048] S1, Preparation of conductive BC / c-MWCNTs nanocomposite film:

[0049] Prepare 100mL uniform suspension of c-MWCNTs (multi-walled carbon nanotubes) with a concentration of 1mg / mL, and a certain amount (9×10 -4 mol L -1 ) cetyl ammonium bromide (CTAB) was mixed with c-MWCNTs uniform suspension to improve its dispersibility, and then ultrasonically dispersed at room temperature for 5 hours through an ultrasonic cleaner with a power of 300W and a frequency of 40kHz to prepare c-MWCNTs suspension.

[0050] Soak the BC membrane in a concentration of 1mol L -1 NaOH solution, treated in a constant temperature water bath at 80°C for 2 hours to remove nutrients and live bacteria, then take out the treated BC membrane and rinse it with deionized water until the pH value is 7; then, clean the treated ...

Embodiment 2 to 6

[0063] The difference from Embodiment 1 of the present invention lies in that the process parameter settings in step S2 and step S3 are different, as shown in the table below.

[0064]

[0065]

[0066] In conjunction with Table 1, embodiments 1 to 7 are analyzed:

[0067]1) The influence of electrochemical polymerization process settings on the detection range of the prepared Cu-based flexible non-enzymatic lactic acid sensor electrode film is: electrochemical polymerization reactions are mostly carried out within a certain voltage range, and the voltage determines the electrode membrane. The extent and rate at which chemical deposition reactions occur. The higher the voltage, the faster the polymerization reaction and the denser the resulting polymer layer, but if the voltage is too high, the transmission between polymer particles will be hindered and the subsequent reaction will be affected.

[0068] When polymerizing pyrrole, when the polymerization voltage is the s...

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Abstract

The invention provides a Cu-based flexible non-enzymatic lactic acid sensor electrode film and a preparation method thereof. According to the preparation method, a BC film is used as a carrier for constructing a flexible electrode material in a biosensor, a multi-walled carbon nanotube with good electrical conductivity and large specific surface area is used as an electrical conductive material, the BC film and the multi-walled carbon nanotube are compounded to prepare an electrically conductive BC / c-MWCNTs nano composite film; for regulating and controlling the morphology and size of MOFs, the BC / c-MWCNTs nano composite film is polymerized with polypyrrole on the BC / c-MWCNTs nano composite film by an electrochemical polymerization method, and the BC / c-MWCNTs / PPy nano composite film is obtained; and for further improving the lactic acid detection sensitivity, Cu-MOFs are deposited on the surface of the electrically conductive BC / c-MWCNTs / PPy nano composite film by an electrochemical deposition method, and the Cu-based flexible non-enzymatic lactic acid sensor electrode film is prepared. The electrode film is good in stability, low in cost, long in service life, free of influences of environment, temperature, pH and the like and easy to store when used for detecting lactic acid, the concentration of lactic acid in human sweat can be effectively reflected in real time through detection of the electrode film, whether movement is excessive or not can be judged, and the electrode film has huge application prospects.

Description

technical field [0001] The invention relates to the technical field of flexible electrode film preparation, in particular to a Cu-based flexible non-enzyme lactic acid sensor electrode film and a preparation method thereof. Background technique [0002] At present, the common lactic acid detectors on the market mainly use invasive sensors to collect blood from the capillaries of the subject’s fingertips by pricking needles. Repeated collection is not only harmful, but also cannot achieve real-time detection, and is not easy to popularize. [0003] There are related reports in the prior art that the sensor electrodes for detecting the lactic acid content in human sweat and saliva are mainly prepared by lactate oxidase. For example, the invention patent with application number CN202011132178.3 discloses a method for preparing a lactic acid biosensor. The sensor is based on the method of electrochemical deposition, in-situ growth of copper and iron on a certain amount of coppe...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/48
CPCG01N27/327G01N27/48
Inventor 许杰彭松林孙艳杨源柏自奎叶德展
Owner WUHAN TEXTILE UNIV
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