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Ophthalmic composition

A technology of composition and application, applied in the direction of glasses/protective glasses, glasses/goggles, disinfection, etc., can solve problems such as inaccessibility, moisture locking, corneal toxicity damage, etc.

Active Publication Date: 2021-08-27
NAT TAIPEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently on the market, ingredients such as hyaluronic acid or methylcellulose are often added to provide eye moisture. However, although such wetting solutions can bring temporary relief and comfort to contact lens wearers, they still cannot achieve Locks in moisture for a long time and effectively reduces the incidence of dry eye syndrome
In addition, preservatives are often added to the composition of the wetting solution as a bacteriostatic agent, which will easily cause toxic damage to the cornea

Method used

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  • Ophthalmic composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1. Cytotoxicity and Antibacterial Properties of Ophthalmic Compositions

[0029] Materials and methods

[0030] 1. Ophthalmic composition formula

[0031] The formulation of the ophthalmic composition used in this example is shown in Table 1 below.

[0032] Table 1. Formulation (100ml) of the ophthalmic composition

[0033]

[0034] Also contains buffer components: CaCl 2 0.015g, KCl 0.15g, NaCl 0.45g, NaCl 2 HPO 4 0.45-1.8g, pH=6.5-7.5, and surfactant Poloxamer-407, 0.05-0.5g.

[0035] 2. Cytotoxicity test

[0036] Take 100 μL, the concentration is 1×10 5 Cells / mL of L929 (mouse lung fibroblast cell line, Food Industry Development Research Institute of the Foundation, registration number BCRC 60091) cell suspension was added to a 96-well plate, and placed in an environment containing 5±1% carbon dioxide and a temperature of 37±1°C Incubate for 24±2 hours. Aspirate the culture solution, add 100 μL of the prepared ophthalmic composition dilution (ad...

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Abstract

The present invention discloses an ophthalmic composition comprising 0.5-10% (w / v) of γ-PGA and 0.1×10 ‑4 ‑2.0x10 ‑4 % (v / v) ClO 2 . The ophthalmic composition can be used as a contact lens care solution.

Description

【Technical field】 [0001] The present invention relates to an ophthalmic composition, in particular to an ophthalmic composition without preservatives, which can be used for cleaning, moisturizing and / or disinfecting contact lenses. 【Background technique】 [0002] With the continuous advancement of modern technology, many products that emphasize lightness, comfort, and time-saving gradually replace outdated items, creating a variety of items. Contact lenses have gradually developed from early hard lenses to soft lenses, and even today's popular colored multi-style lenses, which solve the obstacles and weight of the spectacle frame, and the risk of possible cracking of the spectacle lens, and provide sports for athletes, players, dancers, and performers. Bringing greater convenience, it is a medical device that is aesthetically pleasing and provides human vision correction. However, contact lenses are in direct contact with the cornea of ​​the eye for a long time. In order to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L12/10A61L12/14G02C13/00
CPCA61L12/102A61L12/14G02C13/008
Inventor 方旭伟曾靖孋吴书璇苏真莹陈佳君黎莉婷
Owner NAT TAIPEI UNIV OF TECH